Publications by authors named "Abdullatif AlEnazi"
Adenosine deaminase 2 deficiency (DADA2), a rare and potentially fatal systemic autoinflammatory disease, is characterized by low or lack of ADA2 activity due to ADA2 mutations. DADA2 symptoms are variable and include vasculitis, immunodeficiency, and cytopenia. Minimal data are available from Saudi Arabia.
View Article and Find Full Text PDFBackground: Systemic juvenile idiopathic arthritis (sJIA) is a diagnosis of exclusion. The complex nature and clinical variety of the disease, as well as the vast clinical variation of disease presentation, may lead to difficulties in disease detection and subsequent delays in treatment.
Aim: To provide a consensus guidance on the management of newly diagnosed sJIA patients among pediatric rheumatologists in Arab countries.
Article Synopsis
- Juvenile idiopathic arthritis (JIA) is a complex and poorly understood condition thought to have genetic influences, characterized by a variety of arthritis types with an unknown origin.
- *The study focused on 43 patients with LACC1-associated juvenile arthritis, identifying genetic variants and providing clinical details, including a high prevalence of early onset disease and aggressive treatment responses.
- *Results showed that a significant portion of patients exhibited severe forms of arthritis and poor treatment outcomes, expanding the understanding of LACC1's role in JIA pathology.
Pattern and diagnostic evaluation of systemic autoinflammatory diseases other than familial Mediterranean fever among Arab children: a multicenter study from the Pediatric Rheumatology Arab Group (PRAG).
Rheumatol Int
January 2020
To define the spectrum and phenotypic characteristics of systemic autoinflammatory diseases (SAIDs) other than familial Mediterranean fever (FMF) in Arab children and to delineate diagnostic evaluation. Data retrospectively collected on patients with clinical and/or genetically proven SAIDs other than FMF at 10 tertiary Arab pediatric rheumatology clinics from 1990 to 2018. The collected data comprised the clinical findings and diagnostic evaluation including genetic testing, the provided treatment and the accrual damage related to SAIDs.
View Article and Find Full Text PDFObjective: To report the indications and safety of biologic agents in childhood rheumatic diseases at a tertiary hospital.
Methods: Children with rheumatic diseases treated with biologic agents at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, from January 2001 to December 2011 were included. All patients were reviewed for: demographic characteristics, diagnosis, concomitant treatment and indications of using biologic agents, age at start of therapy and side effects during the treatment period.
Background And Objective: Published data from Saudi Arabia regarding autoinflammatory diseases are scarce. In this study, we describe the clinical and laboratory features of autoinflammatory diseases in Saudi children.
Design And Setting: Restrospective, hospital-based study conducted from January 2010 until June 2010.