Antioxidant, antibacterial, and antimutagenic activity of seeds extracts.

is a widely used plant in traditional remedies and known for its numerous biological properties. However, fraction-based antioxidant activity and their antimutagenic potential are not yet fully investigated. Different extracts of the seeds were obtained by sequential extraction in different solvents.

Synergistic interaction of eugenol and antimicrobial drugs in eradication of single and mixed biofilms of Candida albicans and Streptococcus mutans.

In vitro eradication of the C. albicans and S. mutans mixed biofilms by eugenol alone and in combination with the antimicrobial drugs.

Biosurfactants: Potential applications as immunomodulator drugs.

Biosurfactants (BSs) molecules are classically branded as emulsifiers of hydrocarbon compounds and are extensively applied in several fields including pharmaceutics, food processing, biodegradation, bioremediation, cosmetics, and pest control management. Due to the amphiphilic and surface-active properties, BS interacts with lipid membranes of the cell and alters its physio-chemical nature. As a result, various biological functions of the target cells are lost.

Virulence and biofilms as promising targets in developing antipathogenic drugs against candidiasis.

has remained the main etiological agent of candidiasis, challenges clinicians with high mortality and morbidity. The emergence of resistance to antifungal drugs, toxicity and lower efficacy have all contributed to an urgent need to develop alternative drugs aiming at novel targets in . Targeting the production of virulence factors, which are essential processes for infectious agents, represents an attractive substitute for the development of newer anti-infectives.

Bioactive extracts of and thymol inhibit biofilm development by multidrug-resistant extended spectrum β-lactamase producing enteric bacteria.

The emergence and spread of multidrug-resistant (MDR) pathogenic bacteria is a clinical problem that requires novel anti-infective agents. Targeting pathogenic biofilms is considered a promising strategy to control bacterial infections. In this study, bioactive extracts of were investigated for their anti-biofilm efficacy against extended spectrum β-lactamase (ESβL) producing MDR enteric bacteria.

Bioactive extracts of L. enhances efficacy of ciprofloxacin against MDR enteric bacteria.

The widespread occurrence of extended spectrum β-lactamases (ESβLs) producing enteric bacteria and their co-resistance with flouroquinolones has impaired the current antimicrobial therapy. This has prompted the search for new alternatives through synergistic approaches with herbal extracts. In this study (seeds) was extracted first in methanol and then subsequently extracted in different organic solvents.

Multidrug resistance and transferability of blaCTX-M among extended-spectrum β-lactamase-producing enteric bacteria in biofilm.

This study aimed to investigate the occurrence of biofilm-forming extended-spectrum β-lactamase (ESBL)-producing enteric bacteria in hospital wastewater and to evaluate their antibiotic resistance behaviour and transferability of the plasmid-encoded blaCTX-M gene in biofilm. ESBL production was confirmed using the combined disc test and Etest. Amplification of blaCTX-M was performed by PCR.