Circular RNAs as Key Regulators in Cancer Hallmarks: New Progress and Therapeutic Opportunities.

Circular RNAs (circRNAs) have emerged as critical regulators in cancer biology, contributing to various cancer hallmarks, including cell proliferation, apoptosis, metastasis, and drug resistance. Defined by their covalently closed loop structure, circRNAs possess unique characteristics like high stability, abundance, and tissue-specific expression. These non-coding RNAs function through mechanisms such as miRNA sponging, interactions with RNA-binding proteins (RBPs), and modulating transcription and splicing.

Bibliometric Analysis of the Top 100 Most Cited Papers in Aesthetic Plastic Surgery.

Objective: To conduct a comprehensive bibliometric analysis of the top 100 most cited papers in aesthetic plastic surgery.

Methods: The analysis utilized VOSviewer, bibliometrix and biblioshiny packages in R. A keyword analysis was performed on all publications.

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead.

Extracellular vesicles (EVs) have emerged as promising tools in diagnostics and therapy for chronic diseases, including cancer and Alzheimer's. Small EVs, also called exosomes, are lipid-bound particles (≈30-150 nm) that play a role in healthy and pathophysiological interactions, including intercellular communication, by transporting bioactive molecules, including proteins, lipids, and nucleic acids. Their ability to cross biological barriers, such as the blood-brain barrier, makes them ideal candidates for targeted therapeutic interventions.

An integrated fuzzy neural network model for surgical approach selection using double hierarchy linguistic information.

The selection of the most effective surgical approach is a critical decision in major surgery. With several approaches available, it is important to select the one that will have the most beneficial effect on the patient's health. Multi criteria decision making techniques are essential for identifying the most effective surgical approach to optimize patient health.

Confirmatory Factor Analysis of the Malay Version of the Malaysia Medication Adherence Assessment Tool (MyMAAT) Among Patients with Chronic Medications.

Purpose: The bilingual Malaysia Medication Adherence Assessment Tool (MyMAAT) was developed using the Exploratory Factor Analysis (EFA) and the current study intended to confirm the measurement model, dimensionality and ensure the factor structure by the Confirmatory Factor Analysis (CFA). The objective of this study was to validate the Malay version of the MyMAAT in measuring medication adherence among participants with chronic medications.

Patients And Methods: A cross-sectional study was conducted using a self-report questionnaire at five health clinics and a hospital in Kuala Lumpur and Putrajaya region between May to November 2023.

A related convolutional neural network for cancer diagnosis using microRNA data classification.

This paper develops a method for cancer classification from microRNA data using a convolutional neural network (CNN)-based model optimized by genetic algorithm. The convolutional neural network has performed well in various recognition and perception tasks. This paper contributes to the cancer classification using a union of two CNNs.

Determination of optimum probiotic dosage for the culture of whiteleg shrimp, in an indoor system.

Determining the optimum application dosage of probiotic in biofloc system is often challenging because the microbial community seems to exert similar effects irrespective of their dosages. It is however noted that certain dosages promote higher yield in shrimp culture more effectively. Principal component analysis was adopted to identify these optimum dosages where 1-way ANOVA could not clearly identify due to the effects of microbial community.

Widespread occurrence of benzimidazole resistance single nucleotide polymorphisms in the canine hookworm, Ancylostoma caninum, in Australia.

Canine hookworm (Ancylostoma caninum), a gastrointestinal nematode of domestic dogs, principally infects the small intestine of dogs and has the potential to cause zoonotic disease. In greyhounds and pet dogs in the USA, A. caninum has been shown to be resistant to multiple anthelmintics.

A Prospective Study Comparing Wide-Awake Local Anesthesia No Tourniquet Versus General Anesthesia in Hand Fracture Fixation.

Purpose: Fixation of metacarpal or phalanx bone fractures is usually performed under general anesthesia (GA) or regional anesthesia and with the use of a tourniquet to minimize bleeding. However, the use of tourniquet causes pain and discomfort after surgery. Wide-awake local anesthesia no tourniquet (WALANT) enables the surgery to be performed with the patient fully awake and without a tourniquet, which allows intraoperative assessment of function during surgery.

Novel biocomposite of ionic cross-linked chitosan and acid-treated potato (Solanum tuberosum L.) peel agro-waste for highly efficient removal of methylene blue dye from water.

In this study, a biocomposite material (CS-OXA/PP-SA) composed of ionic crosslinked chitosan-oxalate (CS-OXA) and chemically modified lignocellulosic biomass (potato (Solanum tuberosum L.) peel-HSO acid, PP-SA) was synthesized to serve as a bioadsorbent for removing methylene blue (MB) dye from aquatic systems. The research utilized response surface methodology (RSM) to evaluate the effects of three variables: CS-OXA/PP-SA dosage (0.

Probing the anticancer activities of facial trioxorhenium and tricarbonylrhenium compounds with heterocyclic ligands.

The cytotoxicity of four rhenium compounds: fac-[ReO(impy)CH] (1) (impy = 2-(1H-imidazole-2-yl)pyridine), fac-[Re(CO)(bzimpy)Cl] (2) (bzimpy = 2-(2-pyridyl)benzimidazole), fac-[Re(CO)(bibzimpy)Cl] (3) (bibzimpy = 2,6-bis(2-benzimidazolyl)pyridine) and fac-[Re(CO)(impy)Cl] (4) was assessed against cancer cell lines, namely, the cervical hormone-responsive HeLa and the triple-negative breast cancer (TNBC) HCC70 lines versus a non-tumorigenic control breast epithelial cell line, MCF12A. A rare facial trioxorhenium(VII) compound 1 was characterized via various physicochemical techniques. The rhenium compounds 1-4 were, in general, more cytotoxic to HeLa cells, compared to the TNBC HCC70 line, displaying half maximal inhibitory concentration (IC) values in the micromolar range, however, the compounds were not convincingly selective for cancer cells over non-cancerous cells.

Selection of third-party logistics in supply chain finance under probabilistic complex hesitant fuzzy sets and distance measures.

Financial institutions attach great importance to the multiple attribute decision-making (MADM) problems of selecting an effective third-party logistics (3PL) service provider in supply chain finance. A suitable 3PL service provider can not only assist financial institutions in carrying out supply chain finance activity but can also replace financial institutions in supervising the operation of a target financing supply chain, therefore minimizing financial institutions' operating risks. However, there is no sufficient study on the selection of a 3PL service provider.

Emerging alternative food protein sources: production process, quality parameters, and safety point of view.

The rise in the global population has increased the demand for dietary food protein. Strategies to maximize agricultural and livestock outputs could strain land and freshwater supply and contribute to substantial negative environmental impacts. Consequently, there has been an emphasis on identifying alternative sources of edible proteins that are more sustainable, sustainable, ethical, and healthy.

Multi-criteria decision support models under fuzzy credibility rough numbers and their application in green supply selection.

As the increasing environmental issues, various companies have take initiatives to produce green products or to select green suppliers which maximize the business performance and minimize the environmental pollution. The real numbers data have imbiguity and uncertainty due to described by classical tools. Therefore, we consider a new type of fuzzy set, fuzzy credibility rough sets.

New insights of LncRNAs fingerprints in breast cancer progression: Tumorigenesis, drug resistance, and therapeutic opportunities.

Breast cancer (BC) is one of the common female cancers and it is characterized by considerable problems regarding its development and therapy. Long non-coding RNAs (lncRNAs) have been identified as significant modulators in BC development, especially, in tumorigenicity and chemoresistance. We therefore endeavor to present an up-to-date understanding of lncRNAs and their impact on BC progression and treatment, concerning molecular processes, treatment options, and use as a therapeutic opportunity.

Nursing students' perceptions of patient safety culture and barriers to reporting medication errors: A cross-sectional study.

Background: Patient safety is critical to high-quality patient care. However, it is liable to medication errors (MEs).

Objective: Therefore, this study assessed perceptions of patient safety culture (PSC) and barriers to reporting MEs among nursing students in Hail City, Saudi Arabia.

A Challenging Diagnosis of Steroid-Responsive Encephalopathy Associated With Autoimmune Thyroiditis (SREAT) in a Systemic Lupus Erythematosus (SLE) Patient With Hashimoto Encephalopathy (HE): A Case Report.

Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a rare condition that can present with multiple neurological and psychiatric manifestations. SREAT diagnosis poses a challenge due to the nature of its nonspecific symptomatology and its overlap with numerous autoimmune, metabolic, infectious, and neuropsychiatric disorders. It is associated with elevated anti-thyroid antibodies, occurs in correspondence with autoimmune thyroiditis, and shows great response to corticosteroid treatment.

Understanding the current provisions of support for people with an intellectual disabilities and/or autism in crisis: A mixed methods study.

Background: There has been significant reduction in inpatient beds for people with intellectual disability and/or autism (PwID/A) in the UK in the last decade following high profile national scandals in specialist psychiatric hospitals. To reduce inappropriate admissions a new strategy (Blue-Light, an emergency multi-disciplinary meeting to prevent admission to hospital) was introduced. However, there is no research on the influence of Blue-Light on crisis management for PwID/A.

Exploring user engagement with real-time verbal feedback from an exoskeleton-based virtual exercise coach.

Objective: Engaging users during physical exercise is crucial for fostering long-term commitment, however, sustaining that engagement remains a significant challenge. This study explores the design of a voice-enabled exoskeleton-based virtual exercise coach (VEC) that provides real-time verbal feedback to enhance user engagement. The objectives of this study are twofold: (i) to compare user engagement with real-time verbal feedback from both VEC and human exercise coach (HEC) during physical exercise, and (ii) to understand users' perceptions and gather their recommendations for improving future VEC technologies.

Thematic Evolution and Scholarly Contributions: A Study of the Top 100 Most Cited Papers in the Journal of Religion and Health.

The Journal of Religion and Health (JORH) has significantly contributed to the intersection of spirituality and healthcare since its inception in 1961. We analyzed the top 100 most cited papers published in JORH, which may provide insights into authorship patterns, institutional affiliations, and publication dynamics. The data was retrieved from the Scopus database.

From Data to Recommendations: A Comprehensive Review of Ten Bibliometric Papers in Aesthetic Plastic Surgery.

This study provides a comprehensive analysis of ten papers published in Aesthetic Plastic Surgery, focusing on the identification of critical gaps and the integration of diverse analytical approaches. Through a detailed review, we observed missing indicators such as comprehensive bibliometric metrics and qualitative assessments of research impact. The findings underscore the need for a more balanced approach in future studies, combining quantitative bibliometric data with qualitative evaluations to provide a fuller understanding of the research landscape.

Enhanced forecasting of rice price and production in Malaysia using novel multivariate fuzzy time series models.

A significant portion of the world's population relies on rice as a primary source of nutrition. In Malaysia, rice production began in the early 1960s, which led to the cultivation of the country's most significant food crop up till the present day. Research on various aspects of the price and production of rice has been done by various methods in the past.

Endometrioid tubal intraepithelial neoplasia (E-TIN): case report & literature review.

An endometrioid carcinogenic pathway of the fallopian tube with possible potential precursors including type II SCOUTs (secretory cell outgrowths) and E-TIN (endometrioid tubal intraepithelial neoplasia) has been recently documented. We report an incidental focus of E-TIN identified in a hysterectomy specimen for Grade 1 endometrioid type endometrial carcinoma. The lesion was present at the fimbriated end of left fallopian tube involving 1 plica.