A Novel Screening System to Characterize and Engineer Quorum Quenching Lactonases.

N-acyl l-homoserine lactones are signaling molecules used by numerous bacteria in quorum sensing. Some bacteria encode lactonases, which can inactivate these signals. Lactonases were reported to inhibit quorum sensing-dependent phenotypes, including virulence and biofilm.

Development of a Multifunctional Chitosan-Based Composite Film from Crab Shell () and Algae () with Enhanced Antioxidant and Antimicrobial Properties for Active Food Packaging.

Eco-friendly, bioactive and edible films from renewable resources are increasingly regarded as viable replacements for petroleum-based packaging. This study investigates the application of macroalgae powder (ULP) as an active additive in crab () chitosan-based films for natural food packaging. Films with ULP concentrations of 0.

Differential regulation of KCC2 and NKCC1 expression by zolpidem in CA1 and CA3 hippocampal subregions of the lithium-pilocarpine status epilepticus rat model.

Status epilepticus is linked to cognitive decline due to damage to the hippocampus, a key structure involved in cognition. The hippocampus's high vulnerability to epilepsy-related damage is the main reason for this impairment. Convulsive seizures, such as those observed in status epilepticus, can cause various hippocampal pathologies, including inflammation, abnormal neurogenesis, and neuronal death.

A Rare Case of Epithelioid Haemangioendothelioma of the Lateral Orbit in a 22-Year-Old Patient.

Epithelioid haemangioendothelioma (EHE) is a rare vascular neoplasm characterised by proliferation of vascular endothelial and pre-endothelial cells. The prevalence is less than one in a million people. It is principally observed in the soft tissues of the extremities but can also occur in the bone, brain, liver, lung and lymph nodes.

Identification of novel BCR::ABL1 kinase domain mutation in patients with chronic myeloid leukaemia and imatinib resistance.

Introduction: The emergence of mutations in the BCR::ABL1 kinase domain (KD) impairs imatinib mesylate (IM) binding capacity, thus contributing to IM resistance. Identification of these mutations is important for treatment decisions and precision medicine in chronic myeloid leukaemia (CML) patients. Our study aims to determine the frequency of BCR::ABL1 KD mutations in CML patients with IM resistance.

Water, Solute, and Ion Transport in De Novo-Designed Membrane Protein Channels.

Biological organisms engineer peptide sequences to fold into membrane pore proteins capable of performing a wide variety of transport functions. Synthetic de novo-designed membrane pores can mimic this approach to achieve a potentially even larger set of functions. Here we explore water, solute, and ion transport in three de novo designed β-barrel membrane channels in the 5-10 Å pore size range.

Brain health is essential for smooth economic transitions: towards socio-economic sustainability, productivity and well-being.

Optimal brain health is essential to smoothing major global skill-intensive economic transitions, such as the bioeconomy, green, care economy and digital transitions. Good brain health is vital to socio-economic sustainability, productivity and well-being. The care transition focuses on recognizing and investing in care services and care work as essential for economic growth and social well-being.

Analysis of the effects of mesh reduction of digital files on the surface area and volume accuracy of complete dentures using an intraoral scanner.

Background: The purpose of this study was to determine the accuracy of an intraoral scanner to digitally duplicate complete dentures and analyze the effects of mesh reduction of digital files on the surface area and volume accuracy of complete dentures, in vitro.

Methods: A mandibular complete denture was scanned by a desktop scanner to create a digital STL reference file (control). Fifteen identical scans were created by using an intraoral scanner and exported as STL files (test group).

Morphometric Analysis of the Dimension and Distance to Anatomical Structures From the Mental Foramen Using Cone Beam Computed Tomography.

Objectives: This study aimed to determine the dimensions and differences in distances from several anatomical structures to the mental foramen (MtF) in Pakistani participants using cone beam computed tomography (CBCT).

Methods: For this cross-sectional study, retrospective CBCT data of Pakistani individuals from both genders were assessed using the Mimics software (Materialise NV, Leuven, Belgium). The participants were selected from the Mahajir and Pukhtoon ethnic groups in Pakistan.

Evaluation of Dermal Wound Healing Potential: Phytochemical Characterization, Anti-Inflammatory, Antioxidant, and Antimicrobial Activities of Euphorbia guyoniana Boiss. & Reut. Latex.

This study investigates the wound-healing potential of Euphorbia guyoniana latex (EGL) in male Wistar rats, along with its biochemical composition and biological activities. Phytochemical analysis identified moderate levels of phenolics, flavonoids, and tannins, with HPLC revealing five phenolic compounds. EGL demonstrated strong antioxidant activity in DPPH assays, surpassing ascorbic acid in protecting red blood cells.

The Promising Key Factors Mediating Secondary Neuronal Damage in the Perihematomal Region of Intracerebellar Hemorrhage of Mice.

The underlying mechanisms of secondary neuronal damage following intracerebellar hemorrhage (ICbH) have not yet been clearly understood. Our previous study reported apoptotic neuronal damage in the perihematomal region (PH) in mice. However, the possible key factors causing secondary neuronal damage in ICbH are not yet known.

Further Insights into The Pathogenic Mechanisms of Haemotropic .

In this study, we examined the effects of experimental intraperitoneal infection with haemotropic (0.5 mL of blood containing 80% parasitaemia) on selected serum biomarkers and cellular pathology in mice. After infection, cells appeared in the blood films within one week.

Sustainable synthesis of ZnO and FeO nanoparticles and their nanocomposite ZnFeO: Comprehensive characterization and applications in antioxidant activity and antibiotics degradation efficiency.

This study focuses on developing and evaluating eco-friendly nanoparticles, specifically FeO NPs, ZnO NPs, and a ZnFeO nanocomposite (NC), for potential applications in environmental remediation and biomedicine. The nanoparticles were synthesized and characterized using X-ray diffraction (XRD), which revealed their crystalline structures with sizes of 20.3 nm for FeO NPs, 22.

Healthy Ageing in Malaysia by 2030: Needs, Challenges and Future Directions.

This Editorial addresses the critical need for developing a healthy ageing society in Malaysia by 2030. With the country's elderly population projected to increase significantly, the article explores current challenges, including healthcare disparities, a shortage of geriatric specialists and malnutrition. It evaluates existing policies and highlights successful international and local initiatives, suggesting specific recommendations to improve healthcare infrastructure, healthy ageing support and technological integration.

Evaluation of the biomechanics of Aramany class I obturators of different designs using numerical and experimental methods. Part II: Stress distribution.

Statement Of Problem: Evidence regarding stress evaluations of removable obturators with Aramany class I defects is lacking. Whether the stress distribution on Aramany class I prostheses can be improved by modifying the currently used designs is also unclear.

Purpose: The purpose of part II of this study was to evaluate the stress distribution in different designs of Aramany class I obturators using finite element analysis (FEA) and photoelastic stress analysis.

Evaluation of the biomechanics of Aramany class I obturators of different designs using numerical and experimental methods. Part I: Retention and associated stress.

Statement Of Problem: Studies on the biomechanics of obturators in the currently used designs of Aramany class I defect are lacking. Also, modifications of the designs presently used in unilateral palatal defects are needed to produce a prosthesis with more retention and less stress on the abutments.

Purpose: The purpose of part I of this study was to differentiate among Aramany class I obturators of 4 designs regarding retention and associated stress using numerical and experimental methods.

Comparative Effect of Antioxidant and Antibacterial Potential of Zinc Oxide Nanoparticles from Aqueous Extract of through Different Precursor Concentrations.

Antibiotic resistance is a global health crisis caused by the overuse and misuse of antibiotics. Accordingly, bacteria have developed mechanisms to resist antibiotics. This crisis endangers public health systems and medical procedures, underscoring the urgent need for novel antimicrobial agents.

Deficiency of adenosine deaminase 2 leading to recurrent Hodgkin lymphoma: A case report.

Deficiency of adenosine deaminase 2 is a rare monogenic multi-organ disease of children and less often adults resulting from mutations in the adenosine deaminase 2 gene. We present a case of a 35-year-old Palestinian male with adenosine deaminase 2 deficiency and maturity-onset diabetes of the young type 2. The patient initially presented with complaints of swelling in his neck and night sweats, leading to a diagnosis of Hodgkin lymphoma.

Post-quantum healthcare: A roadmap for cybersecurity resilience in medical data.

As healthcare systems transition into an era dominated by quantum technologies, the need to fortify cybersecurity measures to protect sensitive medical data becomes increasingly imperative. This paper navigates the intricate landscape of post-quantum cryptographic approaches and emerging threats specific to the healthcare sector. Delving into encryption protocols such as lattice-based, code-based, hash-based, and multivariate polynomial cryptography, the paper addresses challenges in adoption and compatibility within healthcare systems.

Concurrent glossopharyngeal neuralgia and oromandibular dystonia resolved after microvascular decompression of the trigeminal and glossopharyngeal nerve: A rare presentation.

Background: This type of pain syndrome occurs suddenly and briefly, beginning unilaterally from one side of the face. Modestly stimulating speech can provoke it, affecting the ear, tongue, throat, and jaw angle. Interestingly, it is the sensory distribution of the auricular and the pharyngeal branches of the cranial nerves IX and X.

Digital comparative analysis in three dimensions of two impression techniques for the bilateral distal extension of partially edentulous mandibular arches: A pilot clinical study.

Statement Of Problem: The stability of mandibular removable partial dentures with bilateral distal extensions may be improved with the controlled tissue support achieved by using the altered cast impression technique, although this process is time-consuming and technique-sensitive.

Purpose: The purpose of this pilot clinical study was to compare casts generated from a conventional definitive impression with casts generated from an altered cast impression using a 3-dimensional (3D) analysis software program.

Material And Methods: Three partially edentulous participants with mandibular Kennedy Class I were enrolled, and impressions were made with the 2 techniques and poured in stone.