Publications by authors named "Abdullah E Yıldırım"
Acute pancreatitis (AP) is a clinical condition that arises acutely in the pancreas through various inflammatory pathways due to multiple causes. Turkish Society of Gastroenterology Pancreas Working Group developed comprehensive guidance statements regarding the management of AP that include its epidemiology, etiology, clinical presentation, diagnostic criteria, disease severity, treatment, prognosis, local and systemic complications. The statements were developed through literature review, deliberation, and consensus opinion.
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- The study aimed to evaluate the prevalence of pancreatic steatosis (PS) using transabdominal ultrasonography in Turkish gastroenterology clinics and identify associated factors.
- A total of 1,700 volunteers revealed a PS prevalence of 68.9%, with factors like age, BMI, and metabolic syndrome linked to its severity.
- The study also found that 11.8% of PS cases were in lean individuals, who were generally younger and had lower metabolic risk factors compared to those with non-lean PS.
Article Synopsis
- Acute pancreatitis (AP) is a leading gastrointestinal condition causing hospitalization, with a focus on evaluating its clinical features and adherence to international management guidelines.
- The study analyzed 2,144 hospitalized AP patients in Turkey, finding that most cases were mild, with biliary causes being the most common, and an overall mortality rate of 1.6%.
- Results indicate good predictive accuracy for severe cases using specific scoring systems, but show inconsistent adherence to treatment guidelines, particularly in administering prophylactic measures like NSAIDs and antibiotics.
Background And Aim: The aims of the present study were to evaluate the real-life efficacy and tolerability of glecaprevir (GLE)/pibrentasvir (PIB) in the treatment of patients with chronic hepatitis C (CHC).
Materials And Methods: Between May 2019 and May 2022, 686 patients with CHC, treated with GLE/PIB combination from 21 participating centers in Turkiye, were enrolled in the study.
Results: All patients were Caucasian, and their median age was 56 years.
Background: The present study aimed to evaluate the effects of fermented oligosaccharide, disaccharide, monosaccharide and polyols (FODMAP) diet therapy and probiotics on irritable bowel syndrome (IBS) symptoms, quality of life and depression in women diagnosed with IBS.
Methods: For the study, 52 female IBS patients between the ages of 20 and 55 were enrolled. Individuals were monitored for 6 weeks in two groups.
Objective: Sarcopenia is one of the most significant contributors to morbidity in patients with chronic liver disease. Serum myokines are potential biomarkers for detecting early sarcopenia. We aimed to investigate the relationship between serum myokines and cirrhosis-related mortality in the early stages of the disease.
View Article and Find Full Text PDFBackground And Aim: The aim of the present study was to examine the etiology of hepatocellular carcinoma (HCC) by underlying cause and determine the characteristics and clinical features of patients with HCC.
Materials And Methods: The study comprised 1802 HCC patients diagnosed and followed up by Liver Diseases Outpatient Clinics in 14 tertiary centers in Turkey between 2001 and 2020.
Results: The mean age was 62.
Background: We aimed to determine the awareness of referring hepatitis C virus patients to the relevant departments and the effect of the pandemic period on this subject.
Methods: A total of 65 743 patients with anti-hepatitis C virus requests before and during the COVID-19 pandemic were retrospectively screened. Anti-hepatitis C virus-positive patients were divided into 5 groups according to age distribution.
Article Synopsis
- The study aimed to identify the best inflammatory markers for predicting treatment response in patients with culture negative neutrocytic ascites (CNNA) and establish a predictive cutoff value.
- It involved a retrospective analysis of 123 patients, comparing those with CNNA to a control group, examining various blood markers such as neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and C-reactive protein (CRP).
- The findings suggested that combining LMR and CRP provides a reliable, cost-effective, and non-invasive method for predicting treatment response in CNNA patients, with significant sensitivity and specificity results.
Introduction: There is limited research about HBV reactivation (HBVr) due to direct-acting antivirals (DAA) for HCV and most are limited by short duration of follow-up, small sample size, and absence of baseline HBV DNA. We aimed to determine the incidence and clinical course of HBVr in HBsAg and/or anti-HBcIgG positive patients treated with DAA for HCV.
Methods: Seven centers retrospectively analyzed their database on HCV patients treated with DAA between 2015 and 2019.
Article Synopsis
- The study explored how diabetic autonomic neuropathy affects the pancreas's ability to produce digestive enzymes, specifically looking at how this dysfunction, called pancreas exocrine insufficiency (PEI), relates to cardiovascular issues in type 2 diabetes patients.
- Researchers evaluated 110 type 2 diabetes patients and 40 healthy controls, finding a high occurrence of PEI (65.5%) among diabetics and significant differences in autonomic nervous system function between the two groups.
- The study concluded that autonomic neuropathy may disrupt the pancreatic hormone secretion and contribute to PEI in diabetic patients, even without other complicating factors.
Background: There are limited data about the mortality and morbidity of patients with HBV flare related to immunosuppressive treatments (IST) in the third-generation antivirals era. Herein, we performed a multi-centric study in patients treated with entecavir (ETV) or tenofovir disoproxil fumarate (TDF) and evaluated their clinical course.
Methods: The study group included patients who were referred to gastroenterology or infectious disease specialists at eight different hospitals in Turkey.
Does celiac disease cause autoimmune sensorineural hearing loss?
Turk J Gastroenterol
September 2019
Background/aims: The primary aim of this study is to identify whether an autoimmune sensorineural hearing loss is an extraintestinal neurological manifestation in adult CD patients. The secondary aim is to identify whether the duration of a gluten-free diet has an effect on the hearing levels of CD patients.
Materials And Methods: This prospective study consisting of 103 adult CD patients and 79 healthy controls between May 2012 and August 2018 at the University of Gaziantep Gastroenterology and Otorhinolaryngology Departments.
Objectives: To observe the effects of both propofol/alfentanil and propofol/ketamine on sedation during upper gastrointestinal system endoscopy in morbidly obese patients (UGSEMOP).
Methods: In a prospective, double-blinded, randomized clinical study, 52 patients scheduled for UGSEMOP were assigned to either group A (n=26; 10 µg/kg intravenous [IV] alfentanil) or group K (n=26; 0.5 mg/kg IV ketamine).
Experience with endoscopic retrograde cholangiopancreatography in the pediatric population is limited. The aim of this study was to evaluate the outcomes of ERCP in the pediatric population performed by adult gastroenterologists with standard duodenoscopes. This study is a structured retrospective review of endoscopic reports, computerized and paper medical records, and radiographic images of patients under the age of 18 who underwent ERCP for any indication at a tertiary referral centre.
View Article and Find Full Text PDFBackground/aims: The efficacy of immune response against hepatitis C virus (HCV) is determined by human leukocyte antigen (HLA) molecules of the host which present HCV antigens to CD4 + and CD8 + T lymphocytes. In this study, we aimed to investigate the possible relationship between the frequencies of certain HLA class I-II alleles and the natural history of HCV in patients with end-stage renal disease (ESRD).
Settings And Design: This is a retrospective cohort study conducted in a university hospital.
Chylous ascites is the accumulation of lipid-rich lymph in the peritoneal cavity. The usual cause in adults is lymphatic obstruction or leakage caused by malignancy. Non-malignant causes include postoperative trauma, cirrhosis, tuberculosis, pancreatitis and filariasis.
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