Publications by authors named "Abdullah A Hamad"
Objectives: We conducted this meta-analysis of randomized controlled trials (RCTs) to compare the efficacy of adding metformin to lifestyle interventions versus lifestyle interventions alone in individuals with prediabetes.
Materials And Methods: We searched four databases from inception until March 20, 2024. Our primary outcomes included the incidence of type 2 diabetes, hemoglobin A1c (HbA1c), and fasting plasma glucose (FPG).
Introduction: Very important person (VIP) syndrome, or recommended patient syndrome (RPS), is a phenomenon in healthcare where well-intentioned efforts to enhance care inadvertently result in harm. Celebrities, physicians, and political leaders often receive preferential treatment, leading to potentially unnecessary interventions. This review delves into its causes, manifestations, consequences, real-life instances, prevention, and management, considering the shifting paradigm of recent advances in the medical field.
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- This systematic review and meta-analysis aimed to figure out how common venous thromboembolism (VTE) is in patients with amyotrophic lateral sclerosis (ALS) and what factors increase that risk.
- After analyzing data from eight studies with over 26,000 ALS patients, the annual incidence of VTE was found to be approximately 22 cases per 1,000 person-years, with slightly different rates for men and women.
- Key risk factors identified for VTE in ALS patients include a previous history of VTE, the use of non-invasive ventilation, immobility, and a decline in functional status, highlighting the need for preventive measures for these patients.
Insomnia, as a difficulty in initiating and maintaining sleep, coupled with cardiovascular diseases (CVDs) increase the risk of aggravate daytime symptoms, mortality, and morbidity. Cognitive behavioral therapy (CBT) is thought to have a significant impact on insomnia treatment, but in patients with CVDs, there is a paucity of data. To provide a comprehensive appraisal on the impact of CBT on the treatment of insomnia in patients with CVDs.
View Article and Find Full Text PDFHerpes simplex encephalitis (HSVE) is a potentially fatal infectious central nervous system (CNS) disorder. Thus, early detection is critical in determining the case's fate. Clinical history and examination, brain computed tomography, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and lumbar puncture have been used to establish a diagnosis.
View Article and Find Full Text PDFIntroduction: Language barriers in medicine can hinder effective communication, comprehension, and patient care. While English has emerged as the dominant language in global medicine, the importance of native languages should not be overlooked. This article aims to examine the extent of publishing in native languages by analyzing the PubMed database literature to gain further insights into the usage of native languages in medicine and medical research.
View Article and Find Full Text PDFBackground: Cardiovascular diseases (CVDs) are the leading cause of death worldwide and are considered silent killers that threaten different age groups. The stressful lifestyle of resident physicians might make them vulnerable to CVDs. Since 2021, Egypt has recently reported more frequent sudden deaths of junior physicians after long shifts.
View Article and Find Full Text PDFObjectives: This meta-analysis aimed to examine the safety of masitinib in patients with neurodegenerative diseases.
Methods: We considered randomized controlled trials (RCTs) comparing different doses of masitinib versus placebo. We performed our analysis using the R (v.
Dual antiplatelet therapy versus intravenous tissue plasminogen activator with acute minor ischemic stroke: A systematic review and meta-analysis of safety and efficacy.
J Stroke Cerebrovasc Dis
July 2024
Article Synopsis
- This study aimed to compare the safety and effectiveness of Dual Antiplatelet Therapy (DAPT) versus Intravenous Tissue Plasminogen Activator (IV t-PA) for treating minor Acute Ischemic Stroke (AIS).
- A meta-analysis of five studies involving nearly 6,200 patients found no significant differences in treatment efficacy based on modified Rankin scale scores or mortality rates between the two therapies.
- DAPT showed a notably lower risk of bleeding and symptomatic intracranial hemorrhage compared to IV t-PA, suggesting it may be a safer option.
Article Synopsis
- Rett syndrome is a rare genetic disorder that mainly affects females, characterized by the loss of skills, communication difficulties, and repetitive hand movements, highlighting the need for effective treatments.
- The study aimed to assess the safety and effectiveness of trofinetide for treating Rett syndrome through Randomized Controlled Trials, analyzing a total of 59 articles and including three eligible studies for in-depth review.
- Results indicated that trofinetide significantly improved behavior and clinical outcomes at a 200 mg dosage, evidenced by better scores on the Rett Syndrome Behavior Questionnaire and Clinical Global Impression-Improvement, although no notable effects were recorded on motor skills or caregiver concerns.
The use of human amniotic membrane (HAM) has recently gained attention as a promising alternative option for duraplasty due to its superior tensile strength, elasticity, and anti-inflammatory and anti-fibrotic properties, offering greater durability and reliability compared to autologous grafts like the muscle fascia and pericranium. This systematic review aimed to evaluate the complications associated with duraplasty using HAM. We comprehensively searched the PubMed, Scopus, and Web of Science databases for studies on duraplasty with HAM.
View Article and Find Full Text PDFObjectives: Masitinib, originally developed as a tyrosine kinase inhibitor for cancer treatment, has shown potential neuroprotective effects in various neurological disorders by modulating key pathways implicated in neurodegeneration. This scoping review aimed to summarize the current evidence of masitinib's neuroprotective activities from preclinical to clinical studies.
Methods: This scoping review was conducted following the guidelines described by Arksey and O'Malley and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Objectives: This systematic review and meta-analysis aimed to determine the frequency and correlates of fatigue in patients with amyotrophic lateral sclerosis (ALS).
Methods: Three databases were searched up to 2nd May 2023 to identify studies reporting fatigue frequency in ALS. Studies included had to identify ALS patients through one of ALS diagnostic criteria and measure fatigue by a validated tool with a specific cut-off value.
Objectives: Amyotrophic lateral sclerosis (ALS) is a rare and fatal neurodegenerative disease that can overlap with pregnancy, but little is known about its clinical characteristics, course, and outcomes in this context. This systematic review aimed to synthesize the current evidence on ALS overlapping with pregnancy.
Methods: We comprehensively searched four databases on February 2, 2023, to identify case studies reporting cases of ALS overlapping with pregnancy.
Article Synopsis
- Baricitinib is an approved Janus kinase inhibitor for autoimmune disorders, but its effectiveness for systemic lupus erythematosus (SLE) remains uncertain.
- A meta-analysis including three randomized controlled trials found that the 4 mg dose significantly improved patient responses after 24 weeks, while the 2 mg dose showed no clinical benefit.
- Despite the potential of baricitinib 4 mg to lower SLE disease activity, there is an increased risk of serious infections, highlighting the need for more research before widespread use.
Objectives: This study provides a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating the safety and efficacy of lithium in amyotrophic lateral sclerosis (ALS) patients.
Methods: PubMed, Web of Science, Cochrane CENTRAL, Scopus, and Your Journals@Ovid were searched up to 9 December 2022. RCTs investigating lithium, either alone or with any supplement, in ALS patients were included.
This study aimed to assess the perception of COVID-19 risk and the adherence to protective measures among medical students after vaccination. We conducted a cross-sectional survey on a convenience sample of students from all the 18 governmental medical schools in Egypt. A total of 2273 students participated in the online self-administered questionnaire.
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