Recent Advances in Regenerative Endodontics: A Review of Current Techniques and Future Directions.

Regenerative endodontics is a rapidly evolving discipline focused on biologically restoring the pulp-dentin complex to revive vitality in non-vital teeth. Unlike traditional endodontic therapies that rely on inert materials to preserve structure, regenerative techniques aim to re-establish natural structure and function by harnessing advancements in tissue engineering. This narrative review examines recent progress in stem cell applications, scaffold development, signaling molecules, and clinical protocols that contribute to successful regenerative outcomes.

Effect of electronic prescription system modifications on reducing prescribing errors in a military hospital.

Background: The implementation of electronic prescription systems has become a crucial advancement in healthcare, intending to enhance the precision, safety, and effectiveness of the prescription process. Electronic prescription systems provide many solutions to reduce prescribing errors by allowing system modifications that streamline the prescribing process to improve communication between healthcare practitioners In this study, we aimed to explore the effect of electronic prescription system modification on minimising prescribing errors.

Methods: This retrospective quantitative study assessed the effects of electronic prescribing system modification in a tertiary military centre in Saudi Arabia, specifically focusing on decreasing prescribing errors in different hospital departments.

Modeling the Clinical and Economic Burden of Therapeutic Inertia in People with Type 2 Diabetes in Saudi Arabia.

Introduction: Therapeutic inertia in type 2 diabetes, defined as a failure to intensify treatment despite poor glycemic control, can arise due to a variety of factors, despite evidence linking improved glycemic control with reductions in diabetes-related complications. The present study aimed to evaluate the health and economic burden of therapeutic inertia in people with type 2 diabetes in Saudi Arabia.

Methods: The IQVIA Core Diabetes Model (v.

Efficacy of Adenoidectomy versus Tympanostomy on the Otitis Media with Effusion: A Systematic Review and Meta-Analysis.

Background: This systematic review and meta-analysis aimed to investigate the current evidence on the efficacy of tympanostomy and adenoidectomy in children with otitis media with effusion in comparison with tympanostomy alone following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.

Materials And Methods: We completed a comprehensive search of PubMed, Web of Science, Scopus and Cochrane Library databases for relevant studies published in the literature with no date restrictions. We collected the results of the databases search and removed duplicated studies by Rayyan QCRI and EndNote Software X8.

Remediation of water containing lead(II) using (3-iminodiacetic acid) propyltriethoxysilane graphene oxide.

A novel chelating adsorbent based on (3-iminodiacetic acid) propyltriethoxysilane graphene oxide (IAT-GO) has been developed, showing exceptional promise for capturing lead. IAT-GO is made by combining a high-surface-area graphene oxide with a specially designed chelating ligand, which can selectively and efficiently remove lead. The synthesis of IAT-GO involves a two-step progression.

The Trend of Antibiotic Consumption After the COVID-19 Pandemic: Approach to Future Outbreaks.

Background: Earlier reports suggested high rates of antibiotic utilization among COVID-19 patients despite the lack of direct evidence of their activity against viral pathogens. Different trends in antibiotic consumption during 2020 compared to 2019 have been reported.

Purpose: The objective of this study is to assess the impact of COVID-19 pandemic on antibiotic consumption in the presence of active Antibiotic Stewardship Program.

Gas Chromatography-Mass Spectrometry Chemical Profiling of Resin Extracts and Evaluation of Larvicidal, Antioxidant, and Cytotoxic Activities.

Plant extracts and essential oils can be alternative environmentally friendly agents to combat pathogenic microbes and malaria vectors. Myrrh is an aromatic oligum resin that is extracted from the stem of spp. It is used in medicine as an insecticide, cytotoxic, and aromatic.

Endoscopic balloon dilatation for pediatric subglottic stenosis: a meta-analysis of successful outcomes.

Objectives: The primary goal of this study was to systematically identify all relevant published articles on the use of primary endoscopic balloon dilation for the management of pediatric patients with subglottic stenosis, critically assess the technique's success, and determine which patients are the best candidates for the procedure.

Methodology: This was a systematic review and meta-analysis that aimed to investigate the use and success rate of EBD for treating pediatric SGS. An electronic systematic literature search of three major databases, PubMed, EBSCO, and Web of Science&MEDLINE through Clarivate, was conducted to include the eligible articles.

Strigolactone and nitric oxide collaborate synergistically to boost tomato seedling resilience to arsenic toxicity via modulating physiology and antioxidant system.

Arsenic (As) poses a significant environmental threat as a metalloid toxin, adversely affecting the health of both plants and animals. Strigolactones (SL) and nitric oxide (NO) are known to play crucial roles in plant physiology. Therefore, the present experiment was designed to investigate the potential cumulative role of SL (GR24-0.

Genetic Variants of HOTAIR Associated with Colorectal Cancer: A Case-Control Study in the Saudi Population.

Genetic polymorphism in long noncoding RNA (lncRNA) HOTAIR is linked with the risk and susceptibility of various cancers in humans. The mechanism involved in the development of CRC is not fully understood but single nucleotide polymorphisms (SNPs) can be used to predict its risk and prognosis. In the present case-control study, we investigated the relationship between HOTAIR (rs12826786, rs920778, and rs1899663) polymorphisms and CRC risk in the Saudi population by genotyping using a TaqMan genotyping assay in 144 CRC cases and 144 age- and sex-matched controls.

Melatonin involves hydrogen sulfide in the regulation of H-ATPase activity, nitrogen metabolism, and ascorbate-glutathione system under chromium toxicity.

Contamination of soils with chromium (Cr) jeopardized agriculture production globally. The current study was planned with the aim to better comprehend how melatonin (Mel) and hydrogen sulfide (HS) regulate antioxidant defense system, potassium (K) homeostasis, and nitrogen (N) metabolism in tomato seedlings under Cr toxicity. The data reveal that application of 30 μM Mel to the seedlings treated with 25 μM Cr has a positive effect on HS metabolism that resulted in a considerable increase in HS.

Cranial Nerve Impairment Associated With COVID-19 Infections: A Systematic Review.

The COVID-19 pandemic has created huge economic and healthcare burdens. In most cases, the virus affects the lungs and causes respiratory symptoms. Additionally, its impact on the cranial nerves remains unclear.

Assessment of Type II Diabetes Patients' Caregivers' Burnout Level: A Cross-Sectional Study in Taif, Saudi Arabia.

Background: Diabetes mellitus type II (T2D) is a chronic condition that requires significant change in the family behavior and is associated with psychosocial conflicts for both patients and their family environment. The aim of this study is to assess burnout among relatives caring for patients with T2D.

Methods: This cross-sectional study with random sampling was conducted on 501 caregivers of patients with T2D between April and September 2021 at Prince Mansour armed forces hospital in Taif city, Saudi Arabia.

Iron oxide nanoparticles doped biochar ameliorates trace elements induced phytotoxicity in tomato by modulation of physiological and biochemical responses: Implications for human health risk.

Use of untreated municipal wastewater (WW) contains toxic trace elements that pose a serious threat to the soil-plant-human continuum. The use of biochar (BC) is a promising approach to minimize trace element induced toxicity in the ecosystem. Therefore, the present study aims to evaluate the efficacy of BC derived from wheat straw and iron oxide nanoparticles doped biochar (IO-BC) to reduce trace element buildup in soil and plants that consequently affect tomato plant growth and physiological activity under WW irrigation.

Molybdenum and hydrogen sulfide synergistically mitigate arsenic toxicity by modulating defense system, nitrogen and cysteine assimilation in faba bean (Vicia faba L.) seedlings.

Hydrogen sulfide (HS) has emerged as a potential gasotransmitter in plants with a beneficial role in stress amelioration. Despite the various known functions of HS in plants, not much information is available to explain the associative role of molybdenum (Mo) and hydrogen sulfide (HS) signaling in plants under arsenic toxicity. In view to address such lacunae in our understanding of the integrative roles of these biomolecules, the present work attempts to decipher the roles of Mo and HS in mitigation of arsenate (AsV) toxicity in faba bean (Vicia faba L.

Hydrogen sulfide (HS) and potassium (K) synergistically induce drought stress tolerance through regulation of H-ATPase activity, sugar metabolism, and antioxidative defense in tomato seedlings.

Exogenous potassium (K) and endogenous hydrogen sulfide (HS) synergistically alleviate drought stress through regulating H-ATPase activity, sugar metabolism and redox homoeostasis in tomato seedlings. Present work evaluates the role of K in the regulation of endogenous HS signaling in modulating the tolerance of tomato (Solanum lycopersicum L. Mill.

Work and School Absenteeism in Inflammatory Bowel Disease Patients in Jeddah, Saudi Arabia: A Cross-Sectional Study.

Background: Inflammatory bowel disease (IBD), which can have a considerable effect on quality of life, productivity and performance, is typically diagnosed during periods of life in which patients have academic and career-related responsibilities.

Objective: The objective of the study was to determine the effect of IBD symptoms on work and school absenteeism in patients from Saudi Arabia.

Patients And Methods: This cross-sectional survey included patients diagnosed with IBD, aged >8-60 years, at King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

Ascorbate and glutathione independently alleviate arsenate toxicity in brinjal but both require endogenous nitric oxide.

In this study, we have explored the possible role of ascorbic acid (ASC) and glutathione (GSH) in alleviating arsenate (As ) toxicity in brinjal roots. Moreover, we have also focused our attention on the possible involvement of endogenous nitric oxide (NO) in accomplishing this task. As treatment negatively impacts the length and fresh weight of roots and shoots as well as the dry weight and fitness of roots, and this was accompanied by greater As accumulation in roots and shoots of brinjal.

Calcium-hydrogen sulfide crosstalk during K-deficient NaCl stress operates through regulation of Na/H antiport and antioxidative defense system in mung bean roots.

Present investigation reports the role of calcium (Ca) and hydrogen sulfide (HS) crosstalk associated with Vigna radiata seedlings subjected to K deficient conditions under short-term (24 h) and long-term (72 h) NaCl stress. Perusal of the data reveals that under short-term NaCl stress an initial decline in K level led to the elevation in Ca and HS levels along with improvement in antioxidant system and reduction in reactive oxygen species (ROS) production. Under long-term NaCl stress a further decline in K content was deleterious that led to a lower K/Na ratio.

Crosstalk of hydrogen sulfide and nitric oxide requires calcium to mitigate impaired photosynthesis under cadmium stress by activating defense mechanisms in Vigna radiata.

Hydrogen sulfide (HS) and nitric oxide (NO) have been known to affect vast number of processes in plants under abiotic stresses. Also, calcium (Ca) works as a second messenger in plants, which underpins the abiotic stress-induced damage. However, the sequence of action of these signaling molecules against cadmium (Cd)-induced cellular oxidative damage remains unidentified.

Priming of tomato seedlings with 2-oxoglutarate induces arsenic toxicity alleviatory responses by involving endogenous nitric oxide.

Metal toxicity in crop plants is a matter of scientific concern. Therefore, in recent years efforts have been made to minimize metal toxicity in crop plants. Out of various strategies, priming of seedlings with certain chemicals, like e.

Melatonin and calcium function synergistically to promote the resilience through ROS metabolism under arsenic-induced stress.

The interplay between melatonin (Mel) and calcium (Ca) in enhancing tolerance to metalloid toxicity and underlying physiological and biochemical mechanisms of this relationship still remains unknown. The present study reveals that the signaling molecules Mel and/or Ca enhanced tolerance of Vicia faba (cv. Tara) plant to metalloid arsenic (As) toxicity.

Perception and Knowledge of Facial Plastic Surgery Among Health Care Professionals at Tertiary Care Center, Jeddah, Saudi Arabia: Cross Sectional Study.

Introduction: Plastic surgery is a medical specialty involving the restoration, reconstruction, or alteration of the body. Knowledge about facial plastic surgery among doctors is limited according to some literatures and enriched according to others, depending on the country and study population.

Aim: Aim of the study was to evaluate level of knowledge of health care professionals regarding facial plastic surgery.

Perception and Knowledge of Facial Plastic Surgery Among Health Care Professionals at Tertiary Care Center, Jeddah, Saudi Arabia: Cross Sectional Study.

Introduction: Plastic surgery is a medical specialty involving the restoration, reconstruction, or alteration of the body. Knowledge about facial plastic surgery among doctors is limited according to some literatures and enriched according to others, depending on the country and study population.

Aim: Aim of the study was to evaluate level of knowledge of health care professionals regarding facial plastic surgery.