PIK3CA mutation fortifies molecular determinants for immune signaling in vascular cancers.

Angiosarcomas are a group of vascular cancers that form malignant blood vessels. These malignancies are seemingly inflamed primarily due to their pathognomonic nature, which consists of irregular endothelium and tortuous blood channels. PIK3CA mutations are oncogenic and disrupt the PI3K pathway.

A focused review on photocatalytic potential of graphitic carbon nitride (g-CN) based metal oxide-nanostructures for effective remediation of most overused antibiotics.

Researchers in the field of photocatalysis are interested in finding a solution to the problem of charge transfer and recombination in photodegradation mechanisms. The ideal photoactive catalyst would be inexpensive, environmentally friendly, easily manufactured, and highly efficient. Graphitic carbon nitride (g-CN) and metal oxide (MOx) based nanocomposites (g-CN/MOx) are among the photocatalysts that provide the best results in terms of charge transfer capacity, redox capabilities, and charge recombination inhibition.

A Prospective Study Comparing Wide-Awake Local Anesthesia No Tourniquet Versus General Anesthesia in Hand Fracture Fixation.

Purpose: Fixation of metacarpal or phalanx bone fractures is usually performed under general anesthesia (GA) or regional anesthesia and with the use of a tourniquet to minimize bleeding. However, the use of tourniquet causes pain and discomfort after surgery. Wide-awake local anesthesia no tourniquet (WALANT) enables the surgery to be performed with the patient fully awake and without a tourniquet, which allows intraoperative assessment of function during surgery.

Covered Stent Correction for Sinus Venosus Atrial Septal Defects, an Emerging Alternative to Surgical Repair: Results of an International Registry.

Background: Covered stent correction for a sinus venosus atrial septal defect (SVASD) was first performed in 2009. This innovative approach was initially viewed as experimental and was reserved for highly selected patients with unusual anatomic variants. In 2016, increasing numbers of procedures began to be performed, and in several centers, it is now offered as a standard of care option alongside surgical repair.

The prehospital paediatric emergency care burden managed by a public ambulance service in the Western Cape, South Africa.

Background: Paediatric mortality rates in low- and middle-income countries account for over 80% of the global burden. In South Africa, one in every 33 children will not reach the age of five. Despite the high mortality rate, there is a paucity of data describing the prehospital paediatric under-five emergency care burden in South Africa.

The burden and clinical trajectory of immune checkpoint inhibitor-induced endocrinopathies: an 8-year experience.

Background: Immune checkpoint inhibitors (ICIs) have revolutionized the management of cancer patients, but the emergence of ICI-related endocrinopathies (IREs) has introduced new clinical challenges. Despite worldwide recognition of these adverse effects, data from the Middle East is scarce.

Methods: This retrospective-observational study included adult cancer patients who received at least one dose of ICI between January 2015 and January 2023.

Thiol-Functionalized Cobalt Ferrite (CoFeO@MPTS) Nanoparticles as Cutting-Edge Adsorbents for Bovine Serum Albumin.

This paper describes the synthesis of CoFe₂O₄ nanoparticles via a simple ultrasonic-assisted co-precipitation method and their functionalization with thiol groups using (3-Mercaptopropyl)trimethoxysilane (MPTS) as the functionalizing agent. The use of ultrasonic energy not only serves as a green energy source but also reduces the reaction time fivefold compared to conventional methods. The synthesized CoFe₂O₄ nanoparticles were characterized for their surface and internal properties using instrumental techniques such as Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Vibrating Sample Magnetometer (VSM).

Effect of DOPA decarboxylase inhibitor supplements on the incidence of urinary tract infections in Parkinson's disease patients: A systematic review and meta-analysis of randomized controlled trials.

Objectives: Parkinson's disease is the most common neurodegenerative disease. Combining levodopa with other drugs, including decarboxylase inhibitors (DCI) is its most effective treatment. Urinary tract infection (UTI) is the most common cause of hospitalization in Parkinson's patients, making it crucial to find an appropriate treatment to reduce the incidence of this complication.

Novel biocomposite of ionic cross-linked chitosan and acid-treated potato (Solanum tuberosum L.) peel agro-waste for highly efficient removal of methylene blue dye from water.

In this study, a biocomposite material (CS-OXA/PP-SA) composed of ionic crosslinked chitosan-oxalate (CS-OXA) and chemically modified lignocellulosic biomass (potato (Solanum tuberosum L.) peel-HSO acid, PP-SA) was synthesized to serve as a bioadsorbent for removing methylene blue (MB) dye from aquatic systems. The research utilized response surface methodology (RSM) to evaluate the effects of three variables: CS-OXA/PP-SA dosage (0.

An Optimal Internet of Things-Driven Intelligent Decision-Making System for Real-Time Fishpond Water Quality Monitoring and Species Survival.

Smart fish farming faces critical challenges in achieving comprehensive automation, real-time decision-making, and adaptability to diverse environmental conditions and multi-species aquaculture. This study presents a novel Internet of Things (IoT)-driven intelligent decision-making system that dynamically monitors and optimizes water quality parameters to enhance fish survival rates across various regions and species setups. The system integrates advanced sensors connected to an ESP32 microcontroller, continuously monitoring key water parameters such as pH, temperature, and turbidity which are increasingly affected by climate-induced variability.

Structure and Properties of Poly(Ethylene-co-vinyl Acetate) Nanocomposites with Dual-Functionalized Dolomite Nanoparticles.

Poly(ethylene-co-vinyl acetate) (PEVAc) is a copolymer that consists of non-polar polyethylene (PE) and a polar polyvinyl acetate (PVAc) monomer. PEVAc has high elasticity and is resilient, making it suitable for a variety of applications. However, the tensile strength of this copolymer needs to be improved for specific applications that require enough strength to tolerate high external tension or stress.

Probing the anticancer activities of facial trioxorhenium and tricarbonylrhenium compounds with heterocyclic ligands.

The cytotoxicity of four rhenium compounds: fac-[ReO(impy)CH] (1) (impy = 2-(1H-imidazole-2-yl)pyridine), fac-[Re(CO)(bzimpy)Cl] (2) (bzimpy = 2-(2-pyridyl)benzimidazole), fac-[Re(CO)(bibzimpy)Cl] (3) (bibzimpy = 2,6-bis(2-benzimidazolyl)pyridine) and fac-[Re(CO)(impy)Cl] (4) was assessed against cancer cell lines, namely, the cervical hormone-responsive HeLa and the triple-negative breast cancer (TNBC) HCC70 lines versus a non-tumorigenic control breast epithelial cell line, MCF12A. A rare facial trioxorhenium(VII) compound 1 was characterized via various physicochemical techniques. The rhenium compounds 1-4 were, in general, more cytotoxic to HeLa cells, compared to the TNBC HCC70 line, displaying half maximal inhibitory concentration (IC) values in the micromolar range, however, the compounds were not convincingly selective for cancer cells over non-cancerous cells.

Interaction of CO, CO, CSO, HO, NO, NO, NO, O, ONH, and SO gases onto BNNT(m,n)_x, (m = 3, 5, 7; n = 0, 3, 5, 7; x = 3-9).

Context: This research investigates two critical areas, providing valuable insights into the properties and interactions of boron nitride nanotubes (BNNTs). Initially, a variety of BNNT structures (BNNT(m,n)_x, where m = 3, 5, 7; n = 0, 3, 5, 7; x = 3-9) with different lengths and diameters are explored to understand their electronic properties. The study then examines the interactions between these nanotubes and several gases (CO, CO, CSO, HO, NO, NO, NO, O, ONH, and SO) to identify the most stable molecular configurations using the bee colony algorithm for global optimization.

Mesenchymal Stem Cells and Their Derived Exosomes Mitigated Hepatic Cirrhosis in Rats by Altering the Expression of miR-23b and miR-221.

Background: The therapeutic effect of mesenchymal stem cells (MSCs) in liver cirrhosis is limited by their entrapment in the pulmonary vessels. Thus, the use of MSC-derived exosomes has become a promising strategy. The current work aimed to compare the role of human umbilical cord blood-MSCs (hUCB-MSCs) and their derived exosomes in the alleviation of liver cirrhosis focusing on the role of miR-23b and miR-221 and their direct effectors in inflammatory and autophagic pathways.

Selection of third-party logistics in supply chain finance under probabilistic complex hesitant fuzzy sets and distance measures.

Financial institutions attach great importance to the multiple attribute decision-making (MADM) problems of selecting an effective third-party logistics (3PL) service provider in supply chain finance. A suitable 3PL service provider can not only assist financial institutions in carrying out supply chain finance activity but can also replace financial institutions in supervising the operation of a target financing supply chain, therefore minimizing financial institutions' operating risks. However, there is no sufficient study on the selection of a 3PL service provider.

Emerging alternative food protein sources: production process, quality parameters, and safety point of view.

The rise in the global population has increased the demand for dietary food protein. Strategies to maximize agricultural and livestock outputs could strain land and freshwater supply and contribute to substantial negative environmental impacts. Consequently, there has been an emphasis on identifying alternative sources of edible proteins that are more sustainable, sustainable, ethical, and healthy.

Midwife-led birthing centre in the humanitarian setup: An experience from the Rohingya camp, Bangladesh.

In Bangladesh, Midwife Led Birthing Centres (MLBCs) have been established to provide midwifery care and sexual and reproductive health services for the displaced Rohingya population in Cox's Bazar. The aim of this study was to explore MLBCs in this humanitarian context from the perspectives of women, midwives, and other key stakeholders. A mixed-method case study was conducted at one of the MLBCs within the Rohingya refugee camps in Cox's Bazar.

Brain health is essential for smooth economic transitions: towards socio-economic sustainability, productivity and well-being.

Optimal brain health is essential to smoothing major global skill-intensive economic transitions, such as the bioeconomy, green, care economy and digital transitions. Good brain health is vital to socio-economic sustainability, productivity and well-being. The care transition focuses on recognizing and investing in care services and care work as essential for economic growth and social well-being.

Multi-criteria decision support models under fuzzy credibility rough numbers and their application in green supply selection.

As the increasing environmental issues, various companies have take initiatives to produce green products or to select green suppliers which maximize the business performance and minimize the environmental pollution. The real numbers data have imbiguity and uncertainty due to described by classical tools. Therefore, we consider a new type of fuzzy set, fuzzy credibility rough sets.

A model of indoor thermal condition based on traditional acehnese houses using artificial neural network.

This paper examines the thermal condition aspects of traditional Acehnese houses (Rumoh Aceh) in Indonesia. This study highlights the importance of considering traditional architecture in achieving comfortable living conditions. Through the integration of cultural values, architectural design, and environmental factors, this research evaluates the prediction of thermal conditions within Rumoh Aceh based on building orientation and location, serving as guidelines for architects in designing buildings in the Aceh region.

Endoscopic septal perforation repair by endonasal flap: a technique using mobilized septal bone or cartilage for support.

Purpose: Septal perforation refers to a defect within the nasal septum, which subsequently creates communication between the two nasal cavities. More than one surgical approach has been described to repair nasal septal perforations; however, they have a high rate of complication. We aim to introduce a new technique of endoscopic repair of septal perforations, which supports the flap and is thus used to prevent commonly encountered complications.

Jaw vs abdominal Burkitt's lymphoma: An analysis of 25 Iraqi cases.

Objectives: This study compared the clinicopathological, immunohistochemical characteristics and Epstein-Barr virus (EBV) detection of Burkitt's lymphoma (BL) in the abdomen and jaw of Iraqi patients.

Methods: A cohort/retrospective study was carried out between August and September 2024 using 25 tissue blocks (14 gnathic and 11 abdominal BL) from the Oral and Maxillofacial Laboratory, University of Baghdad, College of Dentistry, and the National Centre for Educational Laboratories. The sections were stained with haematoxylin and eosin (H&E), while CD10, CD20, Bcl-2, BCl-6, C-Myc and Ki-67 markers were used for diagnosis.

Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells.

Recent evidence suggests that the gut microbiota can influence pain sensitivity, highlighting the potential for microbiota-targeted pain interventions. During early life, both the microbiota and nociceptors are fine-tuned and respond to environmental factors, however, little is known about how they interact with each other. Using germ-free and gnotobiotic models, we demonstrate that microbiota colonization controls nociceptor sensitivity, partly by modulating mast cell production of nerve growth factor (NGF).

New insights of LncRNAs fingerprints in breast cancer progression: Tumorigenesis, drug resistance, and therapeutic opportunities.

Breast cancer (BC) is one of the common female cancers and it is characterized by considerable problems regarding its development and therapy. Long non-coding RNAs (lncRNAs) have been identified as significant modulators in BC development, especially, in tumorigenicity and chemoresistance. We therefore endeavor to present an up-to-date understanding of lncRNAs and their impact on BC progression and treatment, concerning molecular processes, treatment options, and use as a therapeutic opportunity.

Nursing students' perceptions of patient safety culture and barriers to reporting medication errors: A cross-sectional study.

Background: Patient safety is critical to high-quality patient care. However, it is liable to medication errors (MEs).

Objective: Therefore, this study assessed perceptions of patient safety culture (PSC) and barriers to reporting MEs among nursing students in Hail City, Saudi Arabia.