Efficacy of Micronized Purified Flavonoid Fraction in the Posthemorrhoidectomy Period Trial: Open-Label Randomized Controlled Trial.

Background: Frequent early postoperative complications of hemorrhoidectomy are thrombosis and edema of mucocutaneous "bridges."

Objective: This study aimed to investigate the efficacy of micronized purified flavonoid fraction in preventing complications after elective hemorrhoidectomy.

Design: Prospective unicentral open-label randomized controlled trial.

Genetic Diversity of Barley Accessions from East Asia for Greenbug Resistance.

The greenbug, , is a dangerous pest of barley and other grain crops in the south of Russia. An effective and environmentally friendly way to control this insect is to cultivate resistant varieties. The differential interaction between the phytophage and host plants necessitates the search for new donors of resistance.

Genetic Resources of Cereal Crops for Aphid Resistance.

The genetic resources of cereal crops in terms of resistance to aphids are reviewed. Phytosanitary destabilization led to a significant increase in the harmfulness of this group of insects. The breeding of resistant plant genotypes is a radical, the cheapest, and environmentally safe way of pest control.

Powdery mildew resistance of barley accessions from Dagestan.

Powdery mildew caused by the parasitic fungus (DC.) Golovin ex Speer f. sp.

[Comparative analysis of the semiotics of disseminated pulmonary tuberculosis and exogenous allergic alveolitis in accordance with the data of computed tomography].

Objective: to improve the differential diagnosis of disseminated pulmonary tuberculosis (DPT) and exogenous allergic alveolitis (EAA) via comparative investigation of their computed tomography (CT) semiotics and identification of the most informative diagnostic criteria.

Material And Methods: 70 patients, including 40 patients with DPT in a phase of infiltration and 30 patients with acute EAA, were studied using a Somatom Emotion 16 multi-slice spiral CT scanner (Siemens). All the patients underwent spiral scanning from the upper chest aperture to the costodiaphragmatic recesses with a high CT algorithm at 0.

Incidence and survival of pediatric soft tissue sarcomas in moscow region, Russian Federation, 2000-2009.

The aim of the study was to assess the incidence and survival rates of soft tissue sarcomas (STSs) in children 0-14 years of age in Moscow Region, Russian Federation. The database of childhood population-based cancer registry of Moscow Region was used as a data source. Tumors were stratified according to International Classification of Childhood Cancer, 3d ed.

[Features of metabolic activity of vascular endothelium in patients with pulmonary tuberculosis].

81 patients with active pulmonary tuberculosis were investigated. The morpho-functional status of vascular endothelium was evaluated by plasma levels of stable metabolites of nitric oxide, endothelin-1 and von Willebrand factor antigen. Typical increase of endothelin-1 in positive correlation with systemic inflammatory response syndrome (SIRS) expression was established.

[The specific features of iron intake in patients treated for pulmonary tuberculosis].

Two hundred and forty-three patients with different forms of active pulmonary tuberculosis were examined. The iron intake was estimated by the serum iron (SI) concentrations, total iron-binding capacity (TIBC), unsaturated iron-binding capacity, transferring iron saturation factor (SF), and ferritin (FT) levels. The findings were compared with the values of red blood cells and the systemic inflammatory response assessed from the levels of acute phase reactants (APR).

[Serum nitric oxide level in the assessment of systemic inflammation in patients with drug-resistant pulmonary tuberculosis].

Two hundred and forty-three patients with active pulmonary tuberculosis were examined. Their sera were tested for the level of stable nitric oxide (NO) metabolites, by using the Griess reagent after previous reduction of nitrates to nitrites by a copper-impregnated cadmium reducer. The frank active pulmonary tuberculosis was ascertained to follow the lower serum levels of NO metabolites.

[Evaluation of hepatic function in new cases of pulmonary tuberculosis due to the use of standard chemotherapy regimens I and IIB].

The frequency and magnitude of hepatotoxic reactions were compared in 147 new cases of pulmonary tuberculosis within the first three months of chemotherapy (CT) by standard regimen 1 [H, R, Z, S (E)] (Group 1) and regimen 2B [the same drugs + kanamycin (amikacin) and fluoroquinolones] (Group 2). Their efficiency was evaluated from 6 serum indices--the level of bilirubin, the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AP), and gamma-glutamyl transpeptidase (GGTP), and thymol test results. Tests were monthly carried out.

[Use of fluoroquinolones in the intensive phase of treatment of new tuberculosis cases].

The efficiency of treatment using the routine (I) versus IIB regime was evaluated in 161 new HIV-negative cases of destructive tuberculosis within the first 3 months of chemotherapy. The IIB regimen used in the intensive phase of chemotherapy in new tuberculosis cases before obtaining data on the drug resistance of Mycobacterium tuberculosis significantly enhance the efficiency of treatment in eliminating bacterial excretion and destructive resolution in the lung. The IIB regimen used in new tuberculosis cases with primary multidrug resistance allowed bacterial excretion to be stopped in 80% by month 3 of therapy whereas this index in the similar patients treated by the I regimen was as high as 25%.

[Estimation of serum C-reactive protein values in patients with pulmonary tuberculosis].

Two hundred and forty-three patients with different forms of active pulmonary tuberculosis were examined. The level of C-reactive protein (CRP) was determined by immunoturbidimetry. Its normal values were taken to be 0-3 mg/l.

[A systemic inflammatory response in teenagers with new-onset tuberculosis].

Fifty-eight adolescents aged 13-17 years who had new-onset pulmonary tuberculosis were examined. The serum levels of C-reactive protein (CRP), alpha-antitrypsin (alpha1-AT), haptoglobin (Hp), serum protein fractions, medium-weight molecules (MWM), and malonic dialdehyde (MDA) were assayed in the patients on admission, 2 weeks, and 1, 2, 3, and 6 months after treatment. The parameters of a systemic inflammatory response were ascertained to naturally vary in the adolescents with new-onset tuberculosis, by reflecting as both a defense reaction (increases in the levels of CRP, a,-AT, Hp) and as metabolic decompensation manifestations (increases in the concentrations of MWM and MDA and a reduction in the almubin/globulin (A/G) ratio.

[Qualitative assessment of metabolic shifts accompanying the acutely progressive course of pulmonary tuberculosis].

Eighty-one patients with acutely progressive pulmonary tuberculosis (APPT) (a study group) and 63 patients with involutive pulmonary tuberculosis (a control group) were examined. The magnitude of a systemic inflammatory response was estimated by the values of acute phase reagents (APR) and the blood protein spectrum; the body's iron provision, the state of the hemostatic and fibrinolytic systems, the functional status of mononuclear leukocytes and neutrophils were determined by the basal level of oxygen-dependent and nitrite oxide metabolism and by the capacity of these systems to respond to specific stimulation. In APPT, along with increased APR levels reflecting the mobilization of various components of endogenous defense, the serum (plasma) was found to show the signs of metabolic decompensation as increased catabolic processes and hepatic protein-synthesizing dysfunction in the presence of intravascular inactivation of functionally significant proteins.

[Efficiency of a new standard chemotherapy regimen in the treatment of patients with recurrent pulmonary tuberculosis].

The efficiency of conventional chemotherapy regimens was comparatively studied in 75 patients with recurrent pulmonary tuberculosis. In the patients with recurrent pulmonary tuberculosis, conventional chemotherapy regimen "2b" including isoniazid, rifampicin, pyrazinamide, ethambutol, fluoroquinolone (ofloxacin, ciprofloxacin, and levofloxacin), and canamycin (amikacin) versus conventional chemotherapy regimen "2a" including isoniazid, rifampicin, pyrazinamide, ethambutol, and streptomycin could cease bacterial isolation after 3-month therapy, as evidenced by sputum microscopy (86.1 and 62.

[Changes in the levels of nitric oxide in the mononuclear cells and neutrophils of patients with tuberculosis with varying courses of pulmonary tuberculosis].

A hundred and forty four patients with different types of the course of pulmonary tuberculosis were examined. Before and 20 hours after incubation with BCG-killed cultures, mononuclear cells and neutrophils were used to estimate the level of generation of nitric oxide (NO) from the content of its stabile metabolites--nitrites determined by Griess reagent. Crucially active pulmonary tuberculosis was found to follow the increased leukocytic generation of NO.

[The phenotypes of haptoglobin and the level of acute-phasic proteins in the sera of children with local form of intrathoracic tuberculosis].

Seventy-seven children aged 4-12 years who had local forms of primary intrathoracic tuberculosis were examined. On admission to and discharge from hospital, haptoglobin (Hp) was phenotyped and the content of Hp was measured, and the activity of alpha1-antitrypsin (alpha1-AT) was determined. In all ill children, the distribution of Hp phenotypes did not differ from the normal level, but all patients with tuberculous pleurisy were found to be carriers of Hp1 gene (among them the phenotype Hp 2-2 was absent and the minor variant of Hp 1-1 was detectable in half the cases).

[Diagnosis of latent primary intrathoracic tuberculosis of respiratory system in the phase of calcification in children].

The paper shows the latent activity of newly diagnosed intrathoracic tuberculosis in the phase of calcification in children: clinical and X-ray changes, tuberculin sensitivity (Manteaux test), the presence of Mycobacterium tuberculosis (MBT) in the sputum and blood (cultivation, bacterioscopy, polymerase chain reaction PCR), the blood levels of acute-phase reagents: haptoglobin and alpha 1-protease inhibitor (alpha 1-PI), immunological parameters, tuberculosis antibodies (TAb), and MBT antigen. Ninety children were examined before treatment. Twenty-five children (Group 1) were found to have single minor calcified masses in one group of intrathoracic lymph nodes or in the lung.

[Clinico-immunologic effect of immunomodulin and bactim in duodenal ulcer under environmental pollution conditions].

There was a study of the effect of immunomodulin and bactrim (biseptol-480) preparations in 53 patients with duodenal ulcer living in the ecologically polluted Southern Aral region. It was revealed that the application of immunomodulator immunomodulin and bactrim, a combined sulfanilamide preparation, in combination with the conventional anti-ulcer treatment promotes stronger bactericidal activity with respect to Helicobacter pylori, development of the immune status of the organism, acceleration of ulcer cicatrisation, reduction of the average period of staying in an in-patient hospital, which is an indication of its economic efficiency.

[Iron metabolism in patients with different variants of pulmonary tuberculosis].

Prior to treatment, 48 patients with different forms of pulmonary tuberculosis were examined. Serum iron concentrations, total iron-binding capacity of the serum (STIBC), its unsaturated iron-binding capacity (SUSIB), serum transferrin iron saturation coefficient (SC), total protein in the serum, red blood cells, hemoglobin, colour index were determined. All the parameters under study were in the normal range in patients with a favourable involutional course of pulmonary tuberculosis.

[Biochemical characteristics of fluid and cells of bronchoalveolar washings in patients with extrinsic allergic alveolitis].

In 43 patients with exogenous allergic alveolitis (EAA), including 30 and 13 in its acute and chronic disease, bronchoalveolar lavage was performed, bronchoalveolar washing fluid (BAWF), isolated alveolar macrophages (AM) and unfractionated cellular sediment (NFCS) were separately studied. The BAWF showed high rates of lipid peroxidation (LPO), decreased antiproteolytic defense, and activated local synthesis of haptoglobin (Hp), fibronectin (FN), platelet activation factor (PAF), and enzymes of antioxidative defense (AOD). There was a rise in FN and PAF concentrations in the acute phase of the disease and higher PLO rates and elevated Hp levels in chronic EAA.

[Interconnection between segmentary contractility and dysfunction of left ventricle in patients with post-infarct cardiosclerosis ].

Intracardiac hemodynamics and segmental contractility were studied in 227 patients with postinfarction cardiosclerosis without ischemic cardiomyopathy and chronic aneurysm. Decreased ejection fraction (EF < 50%) was noted in 41 (18.1%) patients.

[Some metabolic characteristics of circulating phagocytes in patients with different types of pulmonary tuberculosis].

Before and 2 and 3 months after chemotherapy, spontaneous and BCG-stimulated nitroblue tetrazolium (NBT) tests, superoxide dismutase (SOD) and catalase activities, the levels of malonic dialdehyde (MDA) and platelet activation factor (PAF) in isolated mononuclear cells and neutrophils were estimated in 169 patients with different forms of pulmonary tuberculosis. Before treatment, in the patients the monocytic bactericidal potential assessed by NBT test parameters was found to increase, but the neutrophilic one reduced due to their basal overirritation. All other test parameters were higher in both types of cells.

[Red blood cell metabolic changes in patients with acutely progressive pulmonary tuberculosis].

In 52 patients with acutely progressive pulmonary tuberculosis (APPT), their red blood cells were used to determine the values of their energy metabolism by lactate dehydrogenase (LDG) and glucose-6-phosphate dehydrogenase (G-6-PDG), the antioxidative defense from the activity of superoxide dismutase (SOD) and catalase and from the levels of malonic dialdehyde (MDA), as well as the intraerythrocytic level of platelet activation factor (PAF) and 2,3-diphosphoglycerinic acid (2,3-DPGA). The concentration of plasma hemoglobin (Hb) was measured as an indicator of spontaneous hemolysis. In the red blood cells from patients with APPT, the activity of LDG and SOD was found to be drastically suppressed, the content of MDA was increased, the intracellular level of PAF was lowered and the concentration of 2,3-DPGA was very moderately elevated.