Publications by authors named "Abdulla AlKhayat"
Objective: This is a comprehensive characteristic study of Kawasaki disease (KD) and Multi system inflammatory syndrome in children (MIS-C) in the Middle East that creates a formula to differentiate between the two.
Methods: We conducted a descriptive comparative study of KD and MIS-C in the United Arab Emirates. Retrospective MIS-C and KD cohorts were recruited between January 2017 until August 2021.
Article Synopsis
- Significant healthcare challenges are posed by rare diseases in underserved areas like the Middle East, which lack genomic diagnostic services.
- A clinical genomics facility was established in the UAE to diagnose and manage rare disease patients, utilizing methods like exome sequencing and chromosomal microarrays, demonstrating a cumulative diagnostic yield of 32.5%.
- The majority of diagnosed Mendelian disorders were identified in young patients, with many receiving delayed diagnoses due to limited access to genetic testing, highlighting the importance of local genomic services for timely management.
Article Synopsis
- The study aimed to examine the incidence of Down syndrome in Dubai, assessing a total of 63,398 newborns over a 5-year period from 1999 to 2003 and confirming 141 cases.
- The overall incidence was found to be 1 in 449 live births, with higher rates among UAE nationals (1 in 319) compared to non-UAE nationals (1 in 602), and key factors included advanced maternal age and higher parity.
- The findings suggest a need for improved genetic counseling and better antenatal screening programs to alleviate the psychological and genetic impacts on families in the region.
Background: There may be a marked reduction in essential amino acids in the serum of children with thalassemia major and this is related to decreased growth in affected children.
Methods: One hundred patients with beta-thalassemia and 50 control children selected from among those who had presented with minor disorders unrelated to hematological disease were recruited. Urine and heparinized blood were collected from fasting thalassemic patients.