Publications by authors named "Abdulkadir Tasdemir"
An involvement of COX and 5-LOX pathways in the penicillin- and pentylenetetrazole (PTZ)-induced epilepsy models.
Fundam Clin Pharmacol
February 2023
Article Synopsis
- The study investigated the connection between epilepsy and inflammation pathways (COX/5-LOX) using rat models induced by penicillin and pentylenetetrazole (PTZ).
- The research involved administering licofelone and esculetin to test their effects on epileptiform activity, with licofelone showing greater effectiveness than esculetin in reducing spike frequency and improving behavioral parameters.
- The findings suggest that inflammation pathways play an important role in controlling epilepsy, indicating that licofelone could be a potential candidate for further research.
Mucositis is a common side effect of cancer therapies and transplant conditioning regimens. Management of mucositis involves multiple approaches from oral hygiene, anti-inflammatory, anti-apoptotic, cytoprotective, and antioxidant agents, to cryo-therapy, physical therapy, and growth factors. There is room for novel, affordable treatment options, or improvement of currently available therapies.
View Article and Find Full Text PDFObjective: This study was aimed at examining the epileptiform activity of the 5-HT serotonin receptor agonist and antagonist, and 5-hydroxytryptophan (5-HTP) in penicillin-induced epilepsy in albino Wistar rats.
Methods: For this purpose, 90 albino male Wistar rats were used in this study. Epileptiform activity was induced by an injection of penicillin, an agonist of GABAA receptor, (500 IU, i.
Background: The most common headache associated with epilepsy occurs after seizure activity and is called a postictal headache. Therefore, the objective of this study was to investigate the effects of low and high doses acetylsalicylic acid (aspirin) on a penicillin-induced experimental epilepsy model.
Methods: Adult male Wistar rats (n = 28, weighing 220 ± 40 g) were used in the experiments.
Traditionally, Morus rubra L. (Moraceae) (red mulberry) and Cornus mas L. (Cornacea) (cornelian cherry) fruits are eaten fresh and are also used in marmalades, juices, jam, natural dyes in Turkey and are believed to have beneficial effects in case of multiple health issues such as antipyretic, diarrhea and intestinal parasites.
View Article and Find Full Text PDFPurpose: The effects of COX-2 inhibitors on seizure activity are controversial. The aim of the current study was to determine the post-treatment effect of aceclofenac on penicillin-induced experimental epilepsy.
Methods: Male Wistar rats were used in all experiments (n=18).