Publications by authors named "Abdulhameed Sabu"
A novel fibrinolytic enzyme, from the marine fungus Penicillium steckii KU1, was purified to electrophoretic homogeneity. The fibrinolytic protease was purified to 13.56 times with a specific activity of 57.
View Article and Find Full Text PDFOveruse of antibiotics coupled with biofilm-forming ability has led to the emergence of multi-drug P. aeruginosa strains worldwide. Quorum sensing is a bacterial cell-cell communication system that regulates the expression of genes, including virulence factors, through production of acyl-homoserine lactones (AHLs) in Pseudomonas aeruginosa.
View Article and Find Full Text PDFArticle Synopsis
- Phycocyanin (PC) is believed to interact with multiple biological systems, suggesting it has diverse effects, although its specific mechanisms of action remain unclear.
- Recent research focuses on PC's ability to inhibit the pro-inflammatory enzyme lipoxygenase (LOX), indicating that the structure of PC is critical for this inhibitory action.
- Studies using molecular dynamics and calorimetry reveal that one PC molecule can bind to two LOX molecules, highlighting its nature as a versatile protein hub that facilitates various non-specific protein interactions.
A direct acting, extracellular, fibrinolytic enzyme, ~50 KDa from marine Pseudomonas aeruginosa KU1 (PEKU1), was purified. It was found to be a metalloprotease. 60% of the total activity of the purified PEKU1 was retained at 70 °C and the enzyme was practically denatured at 80 °C, 2 h.
View Article and Find Full Text PDFCardiovascular diseases are a group of disorders consisting importantly of coronary heart disease, peripheral arterial disease, cerebrovascular disease, rheumatic heart disease, congenital heart disease, deep vein thrombosis and pulmonary embolism. Severe cardiovascular disease conditions lead to acute myocardial infarction and stroke. One of the reasons for this is formation of blood clots inside the vessel.
View Article and Find Full Text PDFArticle Synopsis
- A novel inhibitor, poly(ethyl ethylene ether), was extracted from the marine cyanobacteria Lyngbya confervoides found in North Kerala.
- * The study examined the inhibitor's effects on the enzyme trypsin, including its kinetics and thermodynamic properties.
- * Molecular simulations indicated that the inhibitor effectively blocks the enzyme's substrate binding and catalytic triad, highlighting cyanobacteria as a promising source for new enzyme inhibitors.*
Article Synopsis
- The study investigated phytase production from three Mucor and eight Rhizopus strains using solid-state fermentation (SSF) on natural feed ingredients like canola meal, coconut oil cake, and wheat bran.
- Mucor racemosus NRRL 1994 produced the highest phytase activity (14.5 IU/g dry matter) when grown on coconut oil cake, with optimization raising this to 26 IU/g through the addition of glucose, casein, and (NH(4))(2)SO(4).
- The research found that SSF was more effective than shake flask fermentation for phytase production, and the food-grade Mucor racemosus could be used directly in animal feed, making it a cost
Solid-state fermentation for production of phytase by Rhizopus oligosporus.
Appl Biochem Biotechnol
May 2003
Solid-state fermentation of coconut oil cake has been carried out with Rhizopus oligosporus for the production of phytase. Phytase is used commercially in the animal feed industry to improve animal performance because there is a substantial and growing interest among swine and poultry producers in the application of phytase to improve the nutritional quality in animal feeds. Demonstrated benefits include improved feed yield ratios and reduction in the environmental costs associated with the disposal of animal wastes.
View Article and Find Full Text PDF