Evaluation of the protective properties and genotoxic potential of pyrazolo pyridine derivatives against neutron and gamma radiation using the Ames/ test system.

Purpose: Nuclear applications are being increasingly used in various fields, necessitating studies to protect from radiation hazards and their effects. In this study, five different chemical structures of pyrazolo [3,4-b] pyridine derivatives were synthesized. The gamma and neutron radiation protective abilities of these samples were determined and demonstrated their potential use as ingredients in radioprotective drugs.

Determination of toxicity and radioprotective properties of bacterial and fungal eumelanin pigments.

Purpose: Determination of the protective property of melanin, an organic polymer class consisting of phenolic and/or indolic compounds isolated from bacteria and fungi, against fast neutron radiation. To show that these melanin samples, which also have antioxidant and metal chelating properties, can be used as an active ingredient for a drug to be developed against neutrons used in nuclear research and medicine.

Materials And Methods: Bacterial and fungal media were prepared, and melanin pigments were produced and isolated.

Investigation of radiation protective features of azadispiro derivatives and their genotoxic potential with Ames/ test system.

Purpose: Five different types of synthesized azadispiro derivatives have been analyzed for radiation absorption capacity and determined their potential to be exploited as substances for a drug to be developed against radiation has been investigated.

Material And Methods: Fast neutron attenuation parameters like the effective mean free path, half-value layer (HVL), removal cross-sections, and neutron transmission number were found with the Monte Carlo simulation Geometry And Tracking (GEANT4) code. Gamma radiation absorption parameters, such as effective atom number (), mean free path (MFP), mass attenuation coefficient (MAC), and half-value layer (HVL) were theoretically determined with WinXCom software.

Investigation of neutron and gamma radiation protective characteristics of synthesized quinoline derivatives.

Purpose: Quinoline is formed by various natural compounds, such as alkaloids from the cinchona plant, which exhibit various biological activities, and is an important building material for the development of new drugs. Quinoline can be used in anti-radiation drug development but radiation interaction properties must be determined.

Material And Methods: In this study, six types of synthesized quinoline derivatives were used.

Investigation of neutron shielding properties depending on number of boron atoms for colemanite, ulexite and tincal ores by experiments and FLUKA Monte Carlo simulations.

(241)Am-Be source and three samples including different amounts of boron atoms per unit volume called colemanite, ulexite and tincal were used in total macroscopic cross section experiments. Also FLUKA Monte Carlo code was used to simulate total macroscopic cross sections, absorbed doses and deposited energies by low energy neutron interactions. Besides half value layers of samples were calculated and compared to paraffin.

Gamma-irradiated calcium succinate monohydrate single crystal investigation with EPR technique.

In this study, EPR investigation of gamma-irradiated calcium succinate monohydrate [CaC(4)H(4)O(4)·H(2)O] single crystal has been carried out at room temperature. The compound crystallizes in monoclinic symmetry with the unit-cell dimensions: a=11.952(2)Å, b=9.

EPR and optical studies of vanadium doped potassium dihydrogen citrate (C6H7KO7) single crystal.

An EPR and optical studies of VO2+ doped potassium dihydrogen citrate (PDHC) single crystals have been carried out at room temperature. It crystallizes in triclinic symmetry with the unit cell dimensions: a=11.343Å, b=13.

An EPR and optical absorption study of Cu(2+) doped in disodium malonate trihydrate single crystal.

Single crystals and powder electron paramagnetic resonance (EPR) studies of Cu(2+)-doped disodium malonate trihydrate [C(3)H(2)O(4)Na(2).3H(2)O] have been carried out at room temperature. The angular variation of the disodium malonate trihydrate single crystal have shown that two different Cu(2+) complexes are located in different chemical environments, and each environment contains one magnetically inequivalent Cu(2+) sites in distinct orientations occupying substitutional positions in the lattice and show very high angular dependence.