Non-typhoidal (NTS) strains are Gram negative bacterial pathogens that are associated with foodborne illness worldwide. During the process of infection, uses two molecular injectisomes known as Type 3 Secretion Systems (T3SS) to secrete virulence factors that are encoded by Pathogenicity Island-1 (SPI-1) and SPI-2 into host cells. These secretion systems play a major role in virulence, as shown in various animal models, but little is known about their role in human infections.
View Article and Find Full Text PDF