Chronic mucocutaneous candidiasis due to signal transducer and activator of transcription 1 mutation in a Saudi patient: a case report.

Chronic mucocutaneous candidiasis (CMC) is a primary immunodeficiency condition caused by a genetic abnormality that increases the risk of recurrent and persistent skin, nail, and mucous membrane infections with Candida species, typically . Signal transducer and activator of transcription 1 (STAT1) gene mutation is a genetic trigger that causes CMC, which increases the risk of infections, multisystem disorders, and cancer susceptibility. We describe the first case of a Saudi female patient with clinical features of CMC with an underlying (STAT1) gene mutation.

Lobular capillary hemangioma post-chemotherapy for T-cell leukemia treated with an antibiotic: a case report.

Background: Lobular capillary hemangioma, also known as pyogenic granuloma (PG), is a relatively common benign rapidly growing friable vascular tumor of the skin and mucus membranes. Although the exact pathogenesis of PG is unknown, many theories discussed the potential of an angiogenic stimulus and an imbalance of inducers and inhibitors triggering the hyperplastic and neovascular response. The most frequently used modality for treatment of PG is surgical treatment.

Exploring pH levels and environmental impacts on handwash products in Riyadh, Saudi Arabia: A cross-sectional study.

Background: The human skin, with a pH of 4 to 6, serves as a barrier against external pathogens. Alkaline handwash products (HWPs) can compromise this barrier and are widely used following the Coronavirus disease-2019 (COVID-19) pandemic. This study aims to determine the pH of a sample of HWPs in Riyadh, Saudi Arabia, and assess the effect of environmental factors on their pH.

Generalized morphea induced by the COVID-19 vaccine in a patient with chronic urticaria.

Adverse events following vaccinations have been noted for centuries, but as of recently, discussions concerning these adverse effects have increased due to the COVID-19 pandemic and the consequent delivery of vaccinations. Through presenting new cases of such adverse events and reviewing the literature, we aim to facilitate the recognition of COVID-19 vaccine-induced autoimmune diseases that may occur in the years after the pandemic has been contained. We report on a case of biopsy-proven morphea after the COVID-19 vaccine, in which case the patient developed diffuse skin lesions all over her body.

UPLC‒ESI‒MS/MS profiling of active polyphenolics in Morinda coreia leaf extract and in vitro antioxidant and antibacterial activity.

In this study, aqueous and methanol extracts of Morinda coreia (MC) leaves were tested for antioxidant and antibacterial activity under in vitro conditions. Phytochemical analysis using UPLC-ESI-MS revealed the presence of phenolics, flavonoids, alkaloids, glycosides, amino acids, proteins, saponins, and tannins. Under in vitro conditions, antioxidant test using DPPH, ABTS, and reducing power demonstrated that the plant leaves play a crucial role in antioxidant activity compared to the commercial antioxidant butylated hydroxytoluene (BHT).

Hearing loss among patients with type 2 diabetes mellitus: a cross-sectional study.

Background: Hearing loss is an underestimated comorbid condition in type 2 diabetes.

Objectives: Investigate hearing loss as a comorbidity associated with type 2 diabetes mellitus and evaluate the factors associated with hearing loss.

Design: Cross-sectional.

Comorbid psychiatric disorders among patients with narcolepsy.

Purpose: This case-control study assessed the prevalence of psychiatric disorders in Arab (Saudi) patients with narcolepsy using a structured clinical interview.

Methods: The study included 74 adult patients with narcolepsy and 265 controls matched for age and sex. Narcolepsy diagnosis was made according to the International Classification of Sleep Disorders-Third Edition.