Upregulation of , , and predicts poor prognosis in pediatric acute myeloid leukemia patients with mutation.

Chromosomal translocations and gene mutations are characteristics of the genomic profile of acute myeloid leukemia (AML). We aim to identify a gene signature associated with poor prognosis in AML patients with compared to AML patients with mutations. RNA-sequencing (RNA-Seq) count data were downloaded from the UCSC Xena browser.

Predicting amplification of using CpG methylation biomarkers in neuroblastoma.

Neuroblastoma is the most common extracranial solid tumor in childhood. Amplification of in neuroblastoma is a predictor of poor prognosis. DNA methylation data from the TARGET data matrix were stratified into amplified and non-amplified groups.

Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles.

Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic signature from gene expression profiles that can serve as prognostic indicators of survival time in patients of high-risk neuroblastoma, and that could be potential therapeutic targets.