Publications by authors named "AbdulShukkur Ebrahim"
Article Synopsis
- Disruption of the retinal pigment epithelial (RPE) barrier is linked to serious eye diseases, but the reasons behind this are not fully understood, prompting the study of how aging and a lack of oxygen affect RPE cells.
- The research utilized Electric Cell-Substrate Impedance Sensing (ECIS) technology to observe the effects of Cobalt(II) chloride (CoCl) on RPE cell barrier integrity, finding that CoCl decreased the electrical resistance of the cells without affecting their overall viability.
- Additionally, Seahorse technology indicated that CoCl diminished key respiratory functions in the RPE cells, coinciding with a significant reduction in the expression of ZO-1, an important protein for maintaining cell barrier integrity.
PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to a region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death by a process called DNA interference. PNT2258 is PNT100 that is encapsulated in protective amphoteric liposomes developed to efficiently encapsulate the PNT100 oligonucleotide, provide enhanced serum stability, optimized pharmacokinetic properties and antitumor activity of the nanoparticle both in vivo and in vitro.
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- The combination of rituximab and 2-CdA shows promise as an effective therapy for B-cell tumors, with 75% of evaluated patients responding positively.
- Research conducted on patient samples and animal models reveals enhanced tumor response, particularly in follicular lymphoma, with significant survival benefits noted post-treatment.
- Molecular analysis indicates that the combination triggers important cellular pathways, including the activation of specific kinases, contributing to the therapeutic efficacy.
Conditional overexpression of four-repeat human tau containing the P301L missense mutation in the rTg4510 mouse model of tauopathy leads to progressive accumulation of neurofibrillary tangles and hyperphosphorylated, sarkosyl-insoluble tau species, which are biochemically comparable to abnormal tau characteristic of hereditary tauopathies termed FTDP-17. To fully understand the impact of tau species at different stages of self-assembly on neurodegeneration, we fractionated rTg4510 brain representing several stages of tauopathy to obtain TBS-extractable (S1), high salt/sarkosyl-extractable (S3), and sarkosyl-insoluble (P3) fractions. Under reducing condition, the S1 fraction was demonstrated by western blotting to contain both 50-60 kDa normally-sized and 64 kDa tau.
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