Blood Transfusion Frequency and Indications in Yemeni Children with Sickle Cell Disease.

Background: Blood transfusion is an essential component in the care of patients with sickle cell disease (SCD), but it might be associated with serious acute and delayed complications. This study was aimed to describe red cell transfusion patterns and indications among hospitalized SCD children in a low-resource setting. A retrospective, descriptive study of all children (≤16 years) with SCD who received blood transfusion therapy during their hospital admissions in the pediatric department at Al-Sadaqa Teaching Hospital in Aden, Yemen, for a period of one year.

Prevalence and correlates of microalbuminuria in Yemeni children with sickle cell disease.

Microalbuminuria (MA) has been recognized as a sensitive marker of early glomerular injury and a predictor of kidney dysfunction in patients with sickle cell disease (SCD). Limited data are available about MA in SCD children in the Arab countries and none from Yemen. The aim of this study is to determine the prevalence and correlates of MA among 101 children aged 1-16 years, with SCD at their steady state.

Assessment of undernutrition using Composite Index of Anthropometric Failure among children aged < 5 years in rural Yemen.

Background: Impaired nutritional status is a major health problem affecting young children in developing countries that has a significant impact on child morbidity and mortality.

Aims: This study aimed to assess the prevalence of undernutrition among children aged < 5 years, using conventional indices and the Composite Index of Anthropometric Failure (CIAF), and then comparing their estimated results.

Methods: A community-based cross-sectional study was conducted and information was collected through house-tohouse visits using precoded structured records.

Intrathoracic kidney in a child with literature review.

Intrathoracic kidney (ITK) is an extremely rare congenital anomaly, often asymptomatic and discovered incidentally on chest radiography. Diagnosis in children is less frequent than in adults. It affects males more than females and is more common on the left side.

Frequency of the MTHFR C677T polymorphism in Yemeni children with sickle cell disease.

The frequency of the methylenetetrahydrofolate reductase enzyme (MTHFR) C677T mutation was determined using polymerase chain reaction (PCR) and with measurement of plasma total homocysteine (tHcy), folate, vitamins B6, B12 and disease severity in 102 SS children from Yemen. The homozygous TT genotype for MTHFR C677T was present in 2% (2/102), and heterozygous CT in 10.8% (11/102), giving an allele frequency of 7.

Clinical profile of sickle cell disease in Yemeni children.

Unlabelled: The clinical spectrum of sickle cell disease (SCD) in the Arabian Peninsula varies widely. This is the first report in Yemeni children.

Methods: A hospital-based, cross-sectional study was undertaken in Al-Wahada Teaching Hospital in Aden of children under 16 years with homozygous (SS) SCD.