The impact of ustekinumab on extraintestinal manifestations of Crohn's disease: A post hoc analysis of the UNITI studies.

Unlabelled: This post hoc analysis of the UNITI studies found ustekinumab (UST) did not significantly improve overall extraintestinal manifestations (EIMs) of Crohn's disease compared to placebo-treated patients at weeks 6 and 52.

Background And Aims: The UNITI trials demonstrated that UST was effective in inducing and maintaining clinical remission in Crohn's disease (CD). However, limited data exists regarding its effectiveness for treatment of EIMs.

Histologic remission does not offer additional benefit for ulcerative colitis patients in endoscopic remission.

Background: Histologic remission in ulcerative colitis (UC) patients may be associated with positive outcomes. It is unclear whether UC patients in endoscopic remission obtain additional benefit from achieving histologic remission.

Aim: To evaluate the relationship between time to relapse and histological activity among UC patients in endoscopic remission.

Efficacy of antimicrobial photodynamic therapy against halitosis in adolescent patients undergoing orthodontic treatment.

Purpose: The aim of the present randomized controlled clinical trial was to evaluate the efficacy of photodynamic therapy (PDT) on halitosis in adolescent patients undergoing fixed orthodontic treatment.

Materials And Methods: Forty-five adolescents with halitosis undergoing orthodontic treatment were equally randomized into three groups: Group - I: provision of treatment through PDT on dorsum of tongue; Group - II: provision of treatment with the help of tongue scrappers (TS); Group - III: provision of treatment with the help of TS and adjunctive PDT. Presence of halitosis confirmed on the basis of gas chromatography and estimation of oral malodour with a cysteine challenge and HS values recorded ≥112 parts per billion (ppb).

Patient-Reported Outcomes and Endoscopic Appearance of Ulcerative Colitis: A Systematic Review and Meta-analysis.

Background & Aims: We aimed to evaluate the association of the patient-reported outcomes for rectal bleeding and stool frequency among patients with ulcerative colitis (UC) in endoscopic remission.

Methods: We performed a systematic review of studies reporting the association of patient-reported outcomes (the patient-reported components of the Mayo score: rectal bleeding and stool frequency) and endoscopic remission (Mayo endoscopic subscore of 0 or 1). We performed a meta-analysis of diagnostic accuracy using the hierarchical bivariate method.

Laparoscopic fertility preservation.

Advances in cancer therapy have improved the long-term survival of young patients suffering from malignancies. The adverse effects of the treatment, however, are sterility and loss of gonadal function especially in females. If preservation of fertility in males by sperm freezing is already established, for young women undergoing cancer treatment the availability of preserving the gonadal function and fertility has just begun.