Publications by authors named "Abdul R Hakeem"
Background: The effect of donor body mass index (BMI) on liver transplantation (LT) outcomes remains unclear.
Methods: A systematic search of the MEDLINE, CENTRAL, Web of Science, and bibliographic reference lists was conducted. All comparative studies evaluating the outcomes of LT in obese (BMI > 30 kg/m) and nonobese donors (BMI < 30 kg/m) were included, and their risk of bias was assessed using the ROBINS-I assessment tool.
Background: Liver disease is the third leading cause of premature death in the UK. Transplantation is the only successful treatment for end-stage liver disease but is limited by a shortage of suitable donor organs. As a result, up to 20% of patients on liver transplant waiting lists die before receiving a transplant.
View Article and Find Full Text PDFPatients of Asian and black ethnicity face disadvantage on the renal transplant waiting list in the UK, because of lack of human leucocyte antigen and blood group matched donors from an overwhelmingly white deceased donor pool. This study evaluates outcomes of renal allografts from Asian and black donors. The UK Transplant Registry was analysed for adult deceased donor kidney only transplants performed between 2001 and 2015.
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- Sir Roy Calne highlighted the challenges of biliary reconstruction in liver transplantation, especially for patients with certain conditions like short-gut syndrome and biliary atresia.
- A unique biliary bypass technique was successfully used in the third liver transplant of a child, involving a sleeve from the stomach's greater curvature.
- The patient has thrived for nearly a decade post-transplant, suggesting this innovative method could be valuable for surgeons facing complex retransplant cases.
Background: Quantification of macrosteatosis (MS) in the liver is important given that it has shown to directly correlate with adverse post-liver transplant (LT) outcomes. With advances in medical technology and an implicit understanding of pathology, noninvasive methods of quantitatively assessing MS are in various stages of development. Each of these methods is based on the physical principles of differences between a fat-laden hepatocyte and a normal one.
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- - The 2023 Congress of ILTS, ELITA, and LICAGE in Rotterdam was a pivotal event for the liver transplant community, marking a recovery after COVID-19 with 1159 participants and increased abstract submissions.
- - The conference centered around "Liver Disorders and Transplantation: Innovations and Evolving Indications," covering various topics in Hepatology, Surgical Approaches, and more.
- - It served as a vital platform for discussions on advancements and collaborative efforts in the liver transplant field, highlighting ongoing innovations and evolving practices.
Article Synopsis
- - Small-for-size syndrome (SFSS) is a significant complication that can occur in up to 20% of patients after living donor liver transplantation (LDLT), requiring careful planning and surgical considerations to prevent it.
- - A conference held in January 2023 led by international experts focused on developing evidence-based recommendations for predicting and managing SFSS in LDLT, utilizing a structured evaluation system.
- - The final recommendations from one of the conference's working groups emphasize best practices in donor and recipient selection, surgical techniques, and critical care strategies to reduce the risk of SFSS in patients undergoing LDLT.
Article Synopsis
- The 27th Annual Congress of the International Liver Transplantation Society took place from May 4 to 7, 2022, in Istanbul, with a hybrid format allowing both in-person and online attendance.
- The event saw participation from 1123 liver transplant professionals across 61 countries, and nearly 500 scientific abstracts were presented.
- The Vanguard Committee intended to summarize important invited lectures and noteworthy abstracts from the congress to benefit the liver transplant community.
Background: Children with acute liver failure (ALF) who meet the criteria are eligible for super-urgent transplantation, whereas children with end-stage chronic liver disease (ESCLD) are usually transplanted electively. Pediatric liver trans plantation (PLT) in ALF and ESCLD settings has been well described in the literature, but there are no studies comparing the outcomes in these two groups.
Aim: To determine if there is a difference in post-operative complications and survival outcomes between ALF and ESCLD in PLT.
Background & Aims: Complex portal vein thrombosis (PVT) is a challenge in liver transplantation (LT). Extra-anatomical approaches to portal revascularization, including renoportal (RPA), left gastric vein (LGA), pericholedochal vein (PCA), and cavoportal (CPA) anastomoses, have been described in case reports and series. The RP4LT Collaborative was created to record cases of alternative portal revascularization performed for complex PVT.
View Article and Find Full Text PDFCholangiocarcinoma (CCA) is currently a contraindication to liver transplantation (LT) in the United Kingdom (UK). Incidental CCA occurs rarely in some patients undergoing LT. We report on retrospective outcomes of patients with incidental CCA from six UK LT centres.
View Article and Find Full Text PDFBackground: This meta-analysis aimed to compare progression to surgery, extent of liver hypertrophy, and postoperative outcomes in patients planned for major hepatectomy following either portal vein embolization (PVE) or dual vein embolization (DVE) for management of an inadequate future liver remnant (FLR).
Methods: An electronic search was performed of MEDLINE, Embase, and PubMed databases using both medical subject headings (MeSH) and truncated word searches. Articles comparing PVE with DVE up to January 2022 were included.
Role of Combined CT Pulmonary Angiography and Indirect CT Venography in Diagnosing Venous Thromboembolism in COVID-19 Patients - Experience From an Indian Quaternary Centre.
Vasc Endovascular Surg
February 2023
Objectives: To study the role of combined CTPA and indirect CT venogram to diagnose venous thromboembolism (VTE) in patients with COVID-19 pneumonia and to compare the clinical characteristics, laboratory parameters, CT findings and clinical outcomes between the VTE positive and negative groups.
Methods: In this retrospective study, 131 patients with COVID-19 pneumonia who underwent CTPA and venogram between August 2020 and January 2021 were included. Relevant demographical, clinical and laboratory data and CT images were collected.
The modified derivatives of testosterone, termed as androgenic steroids are indicated in the management of hypogonadism, visceral obesity and metabolic disorders. Anabolic androgenic steroids (AASs) however are surreptitiously used by athletes and body builders for cosmetic purpose owing to their anabolic effects on muscle mass and strength. The unsurveilled use of AASs subjects these users to various side effects involving multiple systems such as the endocrine, genitourinary, hepatobiliary, central nervous, musculoskeletal and psychosocial system.
View Article and Find Full Text PDFBackground: Pure laparoscopic donor hepatectomy (PLDH) for adult living donor liver transplantation (LDLT) remains controversial. The aim of this study was to undertake a systematic review and meta-analysis of donor outcomes following PLDH for adult LDLT.
Materials And Methods: Systematic review in line with the meta-analysis of observational studies in epidemiology guidelines.
Background: The Risk Estimation of Tumor Recurrence After Transplant (RETREAT) score as a prognostic index for recurrence has been reported previously and has not been validated outside the USA. Our study has validated the score in a single center UK cohort of patients being transplanted for HCC.
Methods: LT for HCC between 2008 and 2018 at our center were analyzed.
Article Synopsis
- - The study investigates factors affecting post-transplant survival in pediatric liver transplant (PLT) patients over time, focusing on data from 2000 to 2019 at a single transplant unit.
- - Key findings reveal that recipient age, weight, height, and transplant category significantly influence patient survival, with invasive ventilation noted as a critical factor for those transplanted after 2005.
- - The research highlights that technical advancements and learning curves have positively impacted patient outcomes, suggesting a revision of the belief that smaller candidates have worse survival rates.
Objectives: Therapeutic plasma exchange has been reported to be useful in the management of acute liver failure and acute-on-chronic liver failure. This retrospective study evaluated therapeutic plasma exchange as an adjunct to standard supportive care for early allograft dysfunction after living donor liver transplant.
Materials And Methods: All consecutive adult living donor liver transplants performed from January 2015 to February 2019 were included.
Background: Severe HPS increases morbidity and mortality after LT in children. We reviewed the combined experience of LT for HPS in children from two LT centers in Europe and Asia.
Methods: All children with "proven" HPS as per ERS Task Force criteria (detailed in manuscript) who underwent LT were categorized into M (PaO ≥80 mmHg), Mo (PaO = 60-79 mmHg), S (50-59 mmHg), and VS (PaO <50 mmHg) HPS, based on room air PaO .
Introduction: Posttransplant lymphoproliferative disorder (PTLD) is a rare complication seen in the period after liver transplant. The commonest subtype is B-cell PTLD which is usually associated with Epstein-Barr virus (EBV) infection. T-cell PTLD is rare and the association with EBV is again rarer.
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