A novel diode laser intervention in the management of external invasive cervical resorption.

"Invasive cervical resorption (ICR)" is a rare category of "external root resorption." It is a progressive and destructive condition with an unclear cause. Managing external "ICR" presents a significant challenge, even to the most seasoned dental professionals.

Root canal therapy used in conjunction with follow-ups for the nonsurgical handling of an enormous periapical lesion of endodontic origin: Clinical case record.

Key Clinical Message: The main objective of root canal therapy is to locate all the canals, cleaning, and shaping, and obturation to obtain fluid tight seal and to heal the periapical lesion if present.

Abstract: The proper cleaning, shaping, and disinfection of the pulp chambers, as well as the filling of the canals, are critical to the efficacy of treatment with root canals. The success of an endodontically treated tooth is dependent on the accuracy of the diagnosis, disinfection, cleaning and shaping, obturation, and finally, the prosthetic rehabilitation management.

A clinical case concerning an extraordinary maxillary second molar having two separate palatal roots.

Key Clinical Message: Main objective of root canal therapy is to locate all the canals, cleaning and shaping, and obturation to obtain fluid tight seal. Failure to locate all canals can lead to the failure of root canal therapy.

Abstract: Variation of pulp aperture, among teeth with multiple roots, constitutes recurring issue during diagnosing and completing efficient endodontic procedures.

Synthesis, Physicochemical and Third Order Nonlinear Optical Properties of Bis-Chalcone (BBDP) as Donor-pi Acceptor Chromophore in Organize Medium.

Bis-Chalcone (BBDP) has been prepared by condensation of N, N-dimethyl benzaldehyde and 1,1'-([1,1'-biphenyl]-4,4'-diyl) di (ethan-1-one), and structure of BBDP was characterized by Mass Spectra, C-NMR, H-NMR, and IR. Physicochemical properties including Dipole-moments, Stoke-Shifts, Oscillator-strength, dielectric constant and quantum-yields of fluorescence of BBDP were investigated by the emission and absorbances in different solvents. Compound (BBDP) displayed bathochromic shift upon increasing the solvent polarity (from n-Hexane to DMSO).

Respiratory Epithelial Adenomatoid Hamartoma in a Young Female: A Diagnostic Dilemma.

Hamartomas are non-neoplastic tissue abnormalities commonly found in various organs but rarely in the upper aerodigestive tract. Respiratory epithelial adenomatoid hamartoma (REAH) is a rare benign proliferation affecting the nasal cavity and sinonasal tract. It often mimics other nasal masses, leading to diagnostic challenges.

A computer vision-based system for recognition and classification of Urdu sign language dataset.

Human beings rely heavily on social communication as one of the major aspects of communication. Language is the most effective means of verbal and nonverbal communication and association. To bridge the communication gap between deaf people communities, and non-deaf people, sign language is widely used.

Brentuximab-Induced Colitis in a Non-Stem-Cell Transplant Patient.

Many chemotherapeutic agents have been associated with drug-induced colitis (DIC). With newer agents' expansion of approval as first-line therapy for common cancers, it is important to be cognizant of their association with DIC. We present a case of brentuximab-associated DIC in an elderly woman with CD30+ Hodgkin lymphoma.

Evaluation of Effects of Various Irrigating Solutions on Chemical Structure of Root Canal Dentin Using FTIR, SEM, and EDS: An In Vitro Study.

Background: Sequential chemical application for irrigating a root canal during chemomechanical debridement can affect the dentin microstructure. Understanding the effects of various irrigants on chemical properties of dentin can elucidate their effects on physical properties and thereby explain the higher incidence of structural failure in endodontically treated teeth. This in vitro research aimed to compare and evaluate the effects of three different irrigating solutions on the chemical structure of root canal dentin in extracted human teeth.

De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma In Situ.

Acute myeloid leukemia (AML) is primarily a disease of older adults and can arise de novo, in relation to previous treatment or in the setting of underlying hematological disease. While it is known to arise from chemoradiation in the setting of breast cancer, little is known about the association between BRCA carriers and AML. We report a case of a young female BRCA carrier who develops de novo AML without prior chemoradiation treatment, and examine if there is a link between BRCA and developing leukemia.

Asymptomatic HyperCKemia: A Diagnostic Trap.

Elevated creatine kinase (CK) levels are the most sensitive indicator of muscle injury. Levels >5000 U/L warns physicians to initiate aggressive hydration and prevent renal failure. We present a rare case of asymptomatic hyperCkemia with levels >80 times the upper limit of normal (ULN), refractory to fluid resuscitation.

Euglycemic Diabetic Ketoacidosis Precipitated by a Keto Diet: Importance of Dietary History in Diagnosis.

Diabetic ketoacidosis (DKA) is one of the serious complications of diabetes, especially type 1. It is defined by the triad of hyperglycemia (>250 mg/dL [>13.9 mmol/L]), high anion-gap metabolic acidosis, and increased plasma ketones.

Theoretical insights on flavanones as antioxidants and UV filters: A TDDFT and NLMO study.

UV radiations can cause several irritations to the skin like sunburn, photo aging and even skin cancer. Sunscreens are widely used to protect the skin against these harmful radiations. One of the ingredients present in these sunscreens are organic molecules capable of absorbing these harmful radiations.

How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?

Interleukin-22 (IL-22) is a pluripotent T cell-derived cytokine which is a member of IL-10 cytokine family. It is the only interleukin produced by immune cells but does not target immune system components. IL-22 is mainly produced by dendritic cells (DCs) and TH17, TH22, NK, and NKT cells and targets a number of body tissues including liver, pancreas, and other epithelial tissues.

Anti-GBM Disease in Pregnancy: Acute Renal Failure Resolved After Plasma Exchange, Hemodialysis, and Steroids.

Antiglomerular basement membrane (GBM) disease presenting during pregnancy is uncommon. We present a case of a pregnant female who presented with acute renal failure requiring dialysis due to anti-GBM disease. She responded well to plasma exchange, high-dose steroids, and hemodialysis.

Density functional theory studies of Pb (II) interaction with chitosan and its derivatives.

Density functional theory (DFT) studies of Pb (II) ions interaction with biopolymer chitosan and its derivatives are presented. Schiff bases and N-alkylated/arylated derivatives of chitosan were characterized as adsorbents of lead ions and are studied at monomer level. Natural bond orbital (NBO) analysis was carried out for chitosan and derivatives to understand the donor-acceptor interactions.

Cuspal movement and microleakage in premolar teeth restored with posterior restorative materials.

Background: With the increase in various resin-based composites with varying monomeric formulations and fi llers had led to a significant number of problems, and one of such is postoperative pain. Clinician is in a dilemma what to select and what not to. The latest nanocomposite is there for a short while that no individual research is available currently, hence, this study was undertaken.

In vitro evaluation of topical fluoride pH and their effect on surface hardness of composite resin-based restorative materials.

Aim: The aim of the study was to correlate the pH and fluoride ion uptake with surface hardness of composite resin based restorative materials after topical fluoride application.

Methodology: Forty disks of each of test materials Composite (Filtek Z350XT, 3M ESPE, St Paul, MN, USA), Resin modified glass ionomer (Vitremer) and Compomer (Dyract AP) were made and ten disks of each material were placed in different test solutions - 1.23% APF gel, Sodium fluoride mouth rinse, 0.

Black cohosh and liver toxicity: is there a relationship?

Herbal supplements are commonly used by patients for various problems. It is a well-known fact that most patients do not tell their physicians about the use of herbal supplements unless they are specifically asked. As a result, sometimes important information regarding drug side effects is missed in history taking.

Severe Hypocalcemia due to Denosumab in Metastatic Prostate Cancer.

Denosumab is a monoclonal antibody used for prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors. Hypocalcemia is a rare and dangerous side effect of the drug Denosumab. We present a case of a patient with metastatic prostate cancer who developed severe hypocalcemia after the administration of the drug.

Anti-GBM of Pregnancy: Acute Renal Failure Resolved after Spontaneous Abortion, Plasma Exchange, Hemodialysis, and Steroids.

Antiglomerular basement membrane disease presenting during pregnancy is very uncommon. We present a case of a pregnant female who presented with acute renal failure needing dialysis from Goodpasture's disease. She responded very well to just plasma exchange, high dose steroids, and hemodialysis.

Mandibular third molar impactions in male adults: Relationship of Operative time and Types of impaction on inflammatory complications.

Background: This paper investigates the relationship betweendifferent types of impactions with postoperativeinflammatory tissue reaction.

Materials & Methods: Consecutive patients with only mandibular third molar impactions were included in our study. They were classified by winter's classification.

In vitro evaluation of antibacterial efficacy of calcium hydroxide in different vehicles.

Aim: This study was aimed to evaluate the antibacterial effect of calcium hydroxide (CH) in different vehicles in an in vitro model.

Materials And Methods: Calcium hydroxide paste prepared with two conventionally used vehicles namely, camphorated monochlophenol, distilled water and propylene glycol. The antibacterial activity of these paste were tested against five micro-organisms that can commonly occur in the infected root canals.

Advancing mandibular swelling: a diagnostic dilemma.

Asymmetrical swelling of the mandible in adolescence may pose a significant diagnostic dilemma. The differential diagnosis ranges from traumatic, infectious, and metabolic processes to benign and malignant tumors. Also may present with similar clinical and radiological features, making an accurate diagnosis quite difficult.

An evaluation of shear bond strength of self-etch adhesive on pre-etched enamel: an in vitro study.

Aim: To determine the shear bond strength of self-etch adhesive G-bond on pre-etched enamel.

Materials And Methods: Thirty caries free human mandibular premolars extracted for orthodontic purpose were used for the study. Occlusal surfaces of all the teeth were flattened with diamond bur and a silicon carbide paper was used for surface smoothening.

Hepatitis B and C infection in first-time blood donors in Karachi--a possible subgroup for sentinel surveillance.

Hepatitis B virus (HBV) and C virus (HCV) are major public health concerns in Pakistan. We conducted a baseline analysis of first-time replacement blood donors at the blood bank of Jinnah Postgraduate Medical Centre in the year 2000 with the view to developing low-cost sentinel surveillance for these infections. Among 7325 such donors, 264 (3.