Strengthening Cause of Death Statistics in Selected Districts of 3 States in India: Protocol for an Uncontrolled, Before-After, Mixed Method Study.

Background: Mortality statistics are vital for health policy development, epidemiological research, and health care service planning. A robust surveillance system is essential for obtaining vital information such as cause of death (CoD) information.

Objective: This study aims to develop a comprehensive model to strengthen the CoD information in the selected study sites.

Unlocking the potential of glucagon-like peptide-1 receptor agonists in revolutionizing type 2 diabetes management: a comprehensive review.

Diabetes mellitus (DM) is a long-term metabolic disorder caused by inadequate production and resistance to insulin. The prevalence of DM is rapidly increasing, with type 2 diabetes (T2D) accounting for more than 90% of cases. Despite new treatments, many patients with T2D do not meet their glycemic targets due to clinical inertia.

PreVenTB trial: protocol for evaluation of efficacy and safety of two vaccines VPM1002 and Immuvac (Mw) in preventing tuberculosis (TB) in healthy household contacts of newly diagnosed sputum smear-positive pulmonary TB patients: phase III, randomised, double-blind, three-arm placebo-controlled trial.

Introduction: Tuberculosis (TB) continues to be one of the deadliest infectious diseases over the centuries, killing more people worldwide than any other single infectious disease. There is an urgent need for additional strategies which can expedite efforts to combat TB including a preventive vaccine. In this endeavour, we have developed a protocol for a multisite, double-blind, placebo-controlled clinical trial in India that aims to evaluate the efficacy and safety of two TB vaccines; namely, VPM1002 and Immuvac () () (MIP) among healthy household contacts (HHCs) of sputum smear-positive pulmonary TB (PTB) patients.

Analyzing the impact of holistic building design on the process of lifecycle management of building structures.

This research examines how Holistic Building Design (HBD) affects Lifecycle Management of Building Structures in the ever-changing construction market. HBD includes adaptability, environmental sustainability, maintenance, and disaster preparation. It is a key idea in the present boom in resilient and sustainable building techniques.

Internet of things (IoT) for safety and efficiency in construction building site operations.

Internet of Things (IoT) technologies present transformative opportunities through connectivity of intelligent devices, environmental sensors, and integrated management systems. This study aims to investigate the benefits and impact of IoT implementation on construction sites by analyzing relationships between key factors and outcomes for safety and efficiency. Hypotheses were developed proposing positive correlations between each factor and effective IoT adoption on construction sites.

Comparative Proteomic Analysis of Cell Wall Proteins of Aminoglycosides Resistant and Sensitive Mycobacterium tuberculosis Clinical Isolates.

Introduction: The rising prevalence of Mycobacterium tuberculosis (M.tb) strains resistant to aminoglycosides (amikacin and kanamycin) challenges effective TB control and treatment. Understanding the mechanisms behind this resistance is crucial since aminoglycosides are a mainstay of TB therapy.

Cytomegalovirus Colitis Mimicking Ulcerative Colitis Flare in an Immunocompromised Patient: A Challenging Diagnosis.

This case report details a 40-year-old male patient with a background of ulcerative colitis (UC), who presented with persistent bloody diarrhea refractory to standard treatment. The clinical picture was initially suggestive of a UC flare-up, prompting the continued use of immunosuppressive therapy. However, histopathological evaluation ultimately revealed cytomegalovirus (CMV) colitis, a condition that can mimic UC exacerbation but requires a distinct treatment approach.

Assessment of cardiovascular risk in patients with ANCA-associated vasculitis: A systematic review and meta-analysis.

Background: Although many chronic inflammatory conditions are linked to elevated cardiovascular risk, the specific extent of this risk in ANCA-associated vasculitis (AAV) remains elusive, largely due to the disease's rarity. Our study sought to clarify the cardiovascular risks and mortality linked to AAV.

Methods: A systematic literature review was conducted across multiple databases from their inception until April 2024 to identify studies comparing cardiovascular outcomes in patients with and without AAV.

The effect of video-assisted learning on pre-operative knowledge and satisfaction for total knee arthroplasty surgery: a randomised-controlled study.

Introduction: Traditionally, surgical procedures are explained through consultations between the surgeon and the patient to ensure informed consent. Patient education enhances engagement and knowledge, aiding informed decision-making. This study aimed to assess the effect of an educational video on preoperative patient knowledge and satisfaction in the context of total knee arthroplasty (TKA) as an adjunct to the consent process.

Short- and long-term outcomes of antegrade versus retrograde approaches in patients undergoing percutaneous coronary intervention for chronic total occlusion: A meta-analysis.

Background: Chronic Total Occlusion (CTO) involves severe coronary artery blockage that impairs blood flow and affects 15-20 % of patients undergoing coronary angiography and over 40 % with diabetes or heart failure. Percutaneous Coronary Intervention (PCI) is used to restore blood flow in such cases. The retrograde approach, developed due to lower success with the antegrade method in complex cases, improves outcomes but increases complications.

Influence of IoT implementation on Resource management in construction.

The desire to increase resource management efficacy in the construction sector is expanding because of measures to reduce costs, boost productivity, and minimize environmental impact. The Internet of Things (IoT) has the potential to alter resource management in the construction sector by delivering real-time data and insights that may assist decision-makers in optimizing resource allocation and usage. Incorporating Internet of Things (IoT) technology into the construction sector will be investigated in this study to discover how resource management is affected.

Synthesis and molecular docking analysis of MBH adducts' derived amides as potential inhibitors.

Humans suffer from various diseases that require more specific drugs to target them. Among the different potent agents, s serve as good antibacterial agents; however, s are resistant to such antibiotics. The present study was designed to prepare efficient inhibitor amides (12-15) from inexpensive, easily accessible, and bioactive precursors; Morita Baylis Hillman (MBH) adducts (5-8).

Malnutrition Severity Predicts Clinical Outcomes in Alcoholic Hepatitis: Evidence from National Data.

Objective: Alcoholic hepatitis (AH) represents a severe manifestation of alcoholic liver disease (ALD) associated with a wide severity spectrum. ALD is linked to nutritional deficiencies, with the gravity of malnutrition escalating as alcohol abuse and ALD progress. This study aims to delve into the impact of malnutrition on the clinical trajectory of AH.

Left Atrial Strain as a Predictor of Early Anthracycline-Induced Chemotherapy-Related Cardiac Dysfunction: A Pilot Systematic Review and Meta-Analysis.

: Chemotherapy-related cardiac dysfunction (CTRCD) significantly affects patients undergoing anthracycline (AC) therapy, with a prevalence ranging from 2% to 20%. Reduced left ventricular ejection fraction (LVEF) and left ventricular global longitudinal strain (LV GLS) are prognostic parameters for CTRCD detection. Our study aimed to investigate the role of emerging parameters such as left atrial strain (LAS).

Comparative Proteomic Analysis of Capsule Proteins in Aminoglycoside-Resistant and Sensitive Mycobacterium tuberculosis Clinical Isolates: Unraveling Potential Drug Targets.

Background: Tuberculosis (TB), a global infectious threat, has seen a concerning rise in aminoglycoside-resistant Mycobacterium tuberculosis (M.tb) strains. The potential role of capsule proteins remains largely unexplored.

Ethnopharmacological uses of fauna among the people of central Punjab, Pakistan.

Introduction: The utilization of fauna and fauna-based byproducts in ethnomedicinal usages has been a longstanding human activity, practiced across various cultures worldwide. This study focuses on investigating the utilization of animal-based traditional medicine by the people of Pakistan, specifically in the Gujranwala area.

Methods: Data collection took place from January to September 2019 through interviews with local communities.

A Paradigm Shift in Non-Small-Cell Lung Cancer (NSCLC) Diagnostics: From Single Gene Tests to Comprehensive Genomic Profiling.

Lung cancer imposes a burden on the health care system worldwide affecting 2 million people and causing 1.8 million deaths in 2021.More than 85% of all lung cancer cases are reported under Non-small-cell lung cancer (NSCLC).

Therapeutic approaches for spinal synovial sarcoma: a comprehensive review of the literature.

Objective: Synovial sarcoma (SS) is a relatively rare type of soft-tissue sarcoma that is commonly treated with surgery, radiation, chemotherapy, and palliative care. Stereotactic radiosurgery (SRS) is an emerging approach that shows promise in treating CNS conditions, but it has not been studied for SS. The authors present a systematic review that explores the effectiveness of different treatments, with a focus on SRS, for managing spinal SS.

Mortality And Prognostic Factors In Patients Operated For Acute Epidural Hematoma.

Background: Epidural hematoma is one of the most common surgical emergencies encountered in neurosurgery. This study was conducted to determine the mortality and prognostic factors in patients operated for traumatic intracranial epidural hematoma in a resource-constrained setting from a developing country.

Methods: This retrospective study was conducted in the Department of Neurosurgery at Ayub Teaching Hospital Abbottabad from 1st January 2019 to 31st Dec 2021.

Alkylimidazolium-based ionic liquids with tailored anions and cations for CO capture.

A systematic investigation was conducted in the present study to determine how various cations and anions affected the solubility of CO. To investigate the influence of different cations and anions on the solubility of CO, twelve ILs were synthesized, characterized, and utilized. These ILs comprised five distinct anions (dioctylsulfosuccinate [DOSS], triflouromethanesulfonate [TFMS], dodecylsulfate [DDS], 3-sulfobezoate [SBA], and benzene sulfonate [BS]), and four distinct cations (1-butyl-3-propanenitrile imidazolium [CCN Bim], 1-hexyl-3-propanenitrile imidazolium [CCN Him], 1-octyl-3-propanenitrile imidazolium [CCN Oim], and 1-decyl-3-propanenitrile imidazolium [CCN Dim]).