Publications by authors named "Abdul Kareem Khan"
Article Synopsis
- Pancreatic ductal adenocarcinoma is the most common type of pancreatic cancer and one of the top causes of cancer-related deaths globally, with a survival rate of less than 8%.
- The disease is often diagnosed late due to its aggressive nature, which leads to early spread of malignant cells, complicating treatment options.
- Treatment options include surgical removal of tumors and various medications, with chemotherapy being the primary choice for advanced cases, but the challenge of drug resistance significantly affects treatment effectiveness.
Article Synopsis
- Pancreatic cancer prognosis has not significantly improved in the last 20 years, necessitating more innovative research to enhance the 5-year survival rate.
- Genetic and proteomic analysis is critical for understanding the complex biology of pancreatic cancer and developing effective therapies, especially through targeted treatments that address both tumors and surrounding stroma.
- The future of pancreatic cancer treatment may rely on novel therapies tailored from genomic and proteomic discoveries, with a focus on immune therapeutics and targeted interventions.
Finding why protein-protein interactions (PPIs) are so specific can provide a valuable tool in a variety of fields. Statistical surveys of so-called transient complexes (like those relevant for signal transduction mechanisms) have shown a tendency of polar residues to participate in the interaction region. Following this scheme, residues in the unbound partners have to compete between interacting with water or interacting with other residues of the protein.
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