Publications by authors named "Abdul Hanan Nagi"
Article Synopsis
- The study examined how specific genetic variations (SNPs) in the CD44 gene affect its protein expression and influence the risk of head and neck squamous cell carcinoma (HNSCC).
- It involved comparing genetic and protein expression data from 85 HNSCC patients and 85 healthy controls, using techniques like immunohistochemistry and DNA sequencing.
- Results showed that the SNP rs13347 was significantly linked to a higher risk of HNSCC, particularly in individuals with the TT genotype, while no connection was found for the SNP rs187115.
Objective: : Oral squamous-cell carcinoma (OSCC) accounts for >90% of oral cancers affecting adults mostly between the fourth to seventh decades of life. The most common OSCC treatment is concomitant chemoradiotherapy (CCRT) having both loco-regional and distant control, but CCRT has acute and chronic toxic effects on adjacent normal tissue. This study aimed to determine the side effects of CCRT on the oral mucosa and to characterize the clinicopathology of oral lesions in patients with OSCC.
View Article and Find Full Text PDFIntroduction/background: Fuhrman nuclear grade is the most important histological parameter to predict prognosis in a patient of renal cell carcinoma (RCC). However, it suffers from inter-observer and intra-observer variation giving rise to need of a parameter that not only correlates with nuclear grade but is also objective and reproducible. Proliferation is the measure of aggressiveness of a tumour and it is strongly correlated with Fuhrman nuclear grade, clinical survival and recurrence in RCC.
View Article and Find Full Text PDFBackground: In Pakistan, urinary bladder carcinoma is the 8th commonest malignancy while being the fourth commonest cancer in men. The relative occurrence of a particular histological type of bladder carcinoma depends on the clinical setting. Both grade and stage of these cancers are highly correlated with recurrence, progression and patient survival rates.
View Article and Find Full Text PDFObjective: To enumerate CDR+CD25+ Treg cells and determine serum IL-6 and IL-17 in type 2 diabetes mellitus patients with retinopathy.
Methods: The case-control study was conducted at the Department of Immunology, University of Health Sciences, Lahore, from November 2009 to January 2012 and comprised diabetic patients and healthy controls who were divided into three groups. Group 1 had controls, while Group 2 had diabetic patients without retinopathy and Group 3 had diabetic patients with retinopathy.