Publications by authors named "Abdul Fahad"
Broad cellular components-initiated efficient chemical reactions that occur in malignant cells may contribute to exploring emerging strategies for cancer treatment. Herein, an ozonated oleogel (OG) was developed to achieve cancer ozone therapy (O-T) based on intracellular Criegee's reaction. By integrating the chemo-drug, the ozone-loaded oleogel (Dox@OG) was prepared as a chemotherapeutic agent for local O-T, associated with chemotherapy (CT)/radiotherapy (RT)/immunotherapy and wound healing.
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- This study introduces material repurposing, focusing on carbonyl iron powder (CIP) as a potential treatment for cancer, building on the successful drug repurposing strategy used in pharmaceuticals.
- The research shows that CIP can enhance the effectiveness of chemotherapy and photothermal therapy, particularly when combined in an injectable alginate hydrogel that rapidly heats tumors under NIR-II laser irradiation.
- The findings indicate that using CIP-ALG in a tumor model leads to effective tumor destruction and inhibition of secondary tumors, demonstrating its promise as a safe and efficient cancer treatment.
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- The study focuses on a novel "nano trap" designed to combat breast cancer by preventing the evasion of cell death, a common issue in tumor progression and treatment resistance.
- This nano trap utilizes disulfiram-loaded nanoparticles combined with calcium and copper ions, which trigger both paraptosis and apoptosis in cancer cells through a carefully engineered release mechanism.
- Experimental results indicate that this dual-ion approach effectively enhances cancer treatment outcomes by inducing cell death and could reshape future strategies for managing tumorigenesis.
Hypoxia may enhance the chemoresistance of cancer cells and can significantly compromise the effectiveness of chemotherapy. Many efforts have been made to relieve or reverse hypoxia by introducing more oxygen into the tumor microenvironment (TME). Acting in a diametrically opposite way, in the current study, a novel nanocarrier was designed to further exhaust the oxygen level of the hypoxic TME.
View Article and Find Full Text PDFSince the nonspecificity and nonselectivity of traditional treatment models lead to the difficulty of cancer treatment, nanobased strategies are needed to fill in the gaps of current approaches. Herein, a tumor microenvironment (TME)-responsive chemo-photothermal treatment model was developed based on dihydroartemisinin (DHA)-loaded conjugated polymers (DHA@PLGA-PANI). The synthesized DHA@PLGA-PANI exhibited enhanced photothermal properties under mild-acidic conditions and thus triggered local heat at the tumor site.
View Article and Find Full Text PDFNanoheterostructures with exquisite interface and heterostructure design find numerous applications in catalysis, plasmonics, electronics, and biomedicine. In the current study, series core-shell metal or metal oxide-based heterogeneous nanocomposite have been successfully fabricated by employing sandwiched liquid metal (LM) layer (i.e.
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