Publications by authors named "Abdouramane Camara"
Article Synopsis
- * Specifically, the researchers found that the transcription factor MIZ1 is essential for the survival of IgG1 B cells during positive selection in GCs, while IgM B cells do not rely on it.
- * MIZ1 helps regulate the anti-apoptotic protein TMBIM4, which manages calcium levels in IgG1 B cells to prevent cell death, highlighting a specific mechanism for Ig isotype selection.
CD169 macrophages reside in lymph node (LN) and spleen and play an important role in the immune defense against pathogens. As resident macrophages, they are responsive to environmental cues to shape their tissue-specific identity. We have previously shown that LN CD169 macrophages require RANKL for formation of their niche and their differentiation.
View Article and Find Full Text PDFInherent immune suppression represents a major challenge in the treatment of human cancer. The extracellular matrix molecule tenascin-C promotes cancer by multiple mechanisms, yet the roles of tenascin-C in tumor immunity are incompletely understood. Using a 4NQO-induced oral squamous cell carcinoma (OSCC) model with abundant and absent tenascin-C, we demonstrated that tenascin-C enforced an immune-suppressive lymphoid stroma via CCL21/CCR7 signaling, leading to increased metastatic tumors.
View Article and Find Full Text PDFTissue-resident macrophages are receptive to specific signals concentrated in cellular niches that direct their cell differentiation and maintenance genetic programs. Here, we found that deficiency of the cytokine RANKL in lymphoid tissue organizers and marginal reticular stromal cells of lymph nodes resulted in the loss of the CD169 sinusoidal macrophages (SMs) comprising the subcapsular and the medullary subtypes. Subcapsular SM differentiation was impaired in mice with targeted RANK deficiency in SMs.
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