Publications by authors named "Abdoulie Jabang"
Article Synopsis
- qPCR is a more efficient method for detecting pathogens in clinical samples than traditional culture methods, which often miss cases, leading to underestimation of disease burden by 2- to 3-fold.
- The Enterics for Global Health (EFGH) study will use a TaqMan Array Card (TAC) to detect and differentiate various pathogens and antimicrobial resistance genes, analyzing samples from rectal swabs or stool.
- The high sensitivity of TAC allows for better estimation of disease burden caused by specific pathogens, which is important for influencing health policy and designing future clinical trials.
Background: The Gambia, located in West Africa, is one of 7 country sites conducting the Enterics for Global Health (EFGH) Surveillance Study to establish incidence and consequence of -associated medically attended diarrhea among children 6-35 months old.
Methods: Here we describe the study site and research experience, sociodemographic characteristics of the study catchment area, facilities of recruitment for diarrhea case surveillance, and known care-seeking behavior for diarrheal illness. We also describe The Gambia's healthcare system and financing, current vaccine schedule and vaccine adaptation, local diarrhea management guidelines and challenges, and antibiotic resistance patterns in the region.
Background: Thioester-containing protein 1 (TEP1) is a highly polymorphic gene playing an important role in mosquito immunity to parasite development and associated with Anopheles gambiae vectorial competence. Allelic variations in TEP1 could render mosquito either susceptible or resistant to parasite infection. Despite reports of TEP1 genetic variations in An.
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- The study aims to compare the population dynamics and ongoing transmission of HIV-1 and HIV-2 in rural Guinea-Bissau through advanced genetic analysis and community epidemiology data.
- It utilized data from multiple surveys over several years, analyzing samples from patients with both HIV types using sophisticated phylogenetic methods to chart their evolution.
- Results revealed that while both viruses showed similar growth patterns initially, HIV-2 appears to have plateaued in transmission, with ongoing infections largely coming from new cases rather than older infections, suggesting that HIV-1 may have influenced the decline of HIV-2 transmission.