Innovative microfluidic model for investigating the intestinal mucus barrier: numerical and experimental perspectives.

The intestinal mucus layer serves as a critical first line of defense against external agents, functioning as a barrier to the absorption of drugs, food, and pathogens. While numerous in vitro studies have explored the role of mucus in preventing particle penetration, the effects of flowing luminal material, dislodging of mucus because of induced shear rate by lumen material and interfacial phenomena remain poorly understood. This study introduces a microfluidic approach to simulate the interaction between flowing luminal material and the mucus layer.

Stress management through cognitive reconstruction and positive thinking in women with recurrent failed In Vitro Fertilization: a randomized controlled trial.

Background: Individuals undergoing fertility treatments often experience heightened stress levels compared to the general population. With the increasing number of women facing recurrent failed in vitro fertilization (IVF) cycles, this research aimed to assess the effectiveness of positive thinking counseling and cognitive reconstruction in reducing perceived stress among infertile women.

Methods: A randomized controlled clinical trial was conducted with 57 women who had undergone unsuccessful IVF cycles at the Fatemiyeh Infertility Center in Hamadan, Western Iran.

Rational strategies for designing next-generation oncolytic viruses based on transcriptome analysis of tumor cells infected with oncolytic herpes simplex virus-1.

Introduction: Oncolytic herpes simplex viruses (oHSVs) are a type of biotherapeutic utilized in cancer therapy due to their ability to selectively infect and destroy tumor cells without harming healthy cells. We sought to investigate the functional genomic response and altered metabolic pathways of human cancer cells to oHSV-1 infection and to elucidate the influence of these responses on the relationship between the virus and the cancer cells.

Methods: Two datasets containing gene expression profiles of tumor cells infected with oHSV-1 (G207) and non-infected cells from the Gene Expression Omnibus (GEO) database were processed and normalized using the R software.

Two distinct psychological concepts: Diabetes depression and diabetes burnout profiles.

Background: Diabetes burnout represents a unique experience that shares some similarities with other psychological concepts. Differentiating diabetes burnout from depression symptoms is a challenging issue. This study aims to examine diabetes burnout profiles and their association with depression.

The effect of probiotic administration on the severity of menopausal symptoms and mental health of postmenopausal women: a triple-blind randomized controlled trial in the West of Iran.

Objective: Menopausal symptoms are a reproductive health issue for women. Some studies have suggested that the use of probiotics may alleviate the severity of menopausal symptoms and mental health status. This study aimed to evaluate the effect of probiotic administration on the severity of menopausal symptoms and improve mental health in postmenopausal women in Hamadan, Western Iran.

A cross-sectional study on domestic violence among infertile women in western Iran.

Background: To date, no study has examined domestic violence among infertile women in western Iran.

Aims: This study aims to investigate the prevalence of domestic violence among infertile women in the region.

Materials And Methods: A cross-sectional study was carried out at the infertility clinic in Hamadan.

Connections matter: Exploring the relationship between belonging and psychosocial well-being in type 1 diabetes in Iran.

Aim: Identify the relationship between a sense of belonging and psychosocial well-being in individuals with type 1 diabetes (T1D) in Iran.

Background: Understanding this relationship is vital for tailored nursing interventions to enhance individual's sense of belonging and improve diabetes outcomes.

Methods: This cross-sectional study included 205 participants selected via multi-stage cluster and simple random sampling from health centers in Iranian.

Resiliency in Persons Experiencing Homelessness: A Concept Analysis Using the Evolutionary Framework.

Introduction: Homelessness is a critical societal issue, with those affected facing disproportionate chronic and acute health conditions. At the core of understanding their experiences is the concept of resiliency. Understanding resiliency in homelessness is crucial because it highlights the dynamic interplay between inherent qualities and external challenges, underscoring the need to reassess societal value judgements and inform nursing practices in research, education and advocacy.

Application of artificial intelligence in modeling of nitrate removal process using zero-valent iron nanoparticles-loaded carboxymethyl cellulose.

This study explores nitrate reduction in aqueous solutions using carboxymethyl cellulose loaded with zero-valent iron nanoparticles (Fe-CMC). The structures of this nano-composite were characterized using various techniques. Based on the characterization results, the specific surface area of Fe-CMC measured by the Brunauer-Emmett-Teller analysis were 39.

Synthesis and molecular docking studies of new aryl imeglimin derivatives as a potent antidiabetic agent in a diabetic zebrafish model.

Diabetes mellitus (DM) is a persistent, progressive, and multifaceted disease characterized by elevated blood glucose levels. Type 2 diabetes mellitus is associated with a relative deficit in insulin mainly due to beta cell dysfunction and peripheral insulin resistance. Metformin has been widely prescribed as a primary treatment option to address this condition.

Enhancing the productivity and proliferation of CHO-K1 cells by oncoprotein YAP (Yes-associated protein).

CHO cells are extensively employed in biological drug industry to manufacture therapeutic proteins. Nevertheless, production of biopharmaceuticals faces obstacles such as limited growth and inadequate productivity. Employing host cell engineering techniques for CHO cells serves as a valuable approach to address the constraints encountered in biologics manufacturing.

Enhancing protein production and growth in chinese hamster ovary cells through miR-107 overexpression.

Chinese Hamster Ovary (CHO) cells are widely employed as host cells for biopharmaceutical production. The manufacturing of biopharmaceuticals poses several challenges, including restricted growth potential and inadequate productivity of the host cells. MicroRNAs play a crucial role in regulating gene expression and are considered highly promising tools for cell engineering to enhance protein production.

Tuning spacer length improves the functionality of the nanobody-based VEGFR2 CAR T cell.

Background: The chimeric antigen receptor-expressing T (CAR-T) cells for cancer immunotherapy have obtained considerable clinical importance. CAR T cells need an optimized intracellular signaling domain to get appropriately activated and also for the proper antigen recognition, the length and composition of the extracellular spacer are critical factors.

Results: We constructed two third-generation nanobody-based VEGFR2-CARs containing either IgG1 hinge-CH2-CH3 region or hinge-only as long or short extracellular spacers, respectively.

Caverno-saphenous shunt for recurrent priapism.

We present a case of medication-induced priapism that was refractory to conventional urologic methods and required treatment with a caverno-saphenous bypass. The patient had been misusing an injectable erectile dysfunction medication consisting of alprostadil, papaverine, and phentolamine (Trimix), resulting in multiple episodes of priapism. His initial episodes of priapism were successfully treated with the traditional urologic algorithm, including phenylephrine, aspiration, and distal shunting.

Changes in phytochemical properties and water use efficiency of peppermint (Mentha piperita L.) using superabsorbent polymer under drought stress.

Water consumption management and the application of advanced techniques in the agricultural sector can significantly contribute to the efficient utilization of limited water resources. This can be achieved by improving soil texture, increasing water retention, reducing erosion, and enhancing seedling germination through the use of superabsorbent polymers. This study aimed to investigate the effect of Aquasource superabsorbent (AS) on the morphological characteristics, phytochemical properties, antioxidant content, and water use efficiency of peppermint.

Enhancing productivity of Chinese hamster ovary (CHO) cells: synergistic strategies combining low-temperature culture and mTORC1 signaling engineering.

The growing demand for recombinant proteins in medicine has prompted biopharmaceutical companies to seek ways to maximize the manufacturing process. Despite its known negative impact on cell growth, temperature shift (TS) has emerged as a cost-effective strategy to enhance protein quantity and quality in Chinese Hamster Ovary cells (CHO). As cells adapt their growth and protein synthesis rate to the environment through influencing mTOR complex 1 (mTORC1), here we evaluated the potential of mTORC1 signaling engineering to improve the production of granulocyte-macrophage colony-stimulating factor (GM-CSF) protein in stable CHO cells at low temperature.

Lenalidomide improves NKG2D-based CAR-T cell activity against colorectal cancer cells invitro.

Introduction: Although CAR-based immunotherapy is viewed as a promising treatment for tumors, particularly hematological malignancies, solid tumors can pose challenges. It has been suggested that the immunomodulatory medication Lenalidomide (LEN) may increase the effectiveness of CAR T cells in the treatment of solid tumors. The purpose of our study was to investigate the effect of NKG2D-based CAR T cell therapy on colorectal cancer cell lines, and then we assessed combinatorial therapy using NKG2D CAR T cells and lenalidomide in vitro.

Psychosocial comorbidities of diabetes during the COVID-19 pandemic in Iran.

Background: The psychosocial impacts of the COVID-19 pandemic are mainly focused on the general population, while pandemics do not impact the mental health of the entire population uniformly, especially vulnerable populations with underlying health conditions. This study aimed to investigate diabetes psychosocial comorbidities among Iranians with type 1 diabetes (T1D) during the COVID-19 pandemic. This study aimed to investigate diabetes psychosocial comorbidities among Iranians with type 1 diabetes (T1D) during the COVID-19 pandemic.

Computational fluid dynamic and response surface methodology coupling: A new method for optimization of the duct to be used in ducted wind turbines.

Wind energy technology, particularly power generation by wind turbines, has received substantial attention due to resource depletion and global warming concerns. These concerns highlight the importance of conducting studies to enhance their efficiency by increasing their power output. The goal of this work was to combine the RSM (Response Surface Methodology (RSM) with CFD (Computational Fluid Dynamics) to discover the optimal design parameters and conditions for ducted wind turbines.

Critical review on phytoremediation of polyfluoroalkyl substances from environmental matrices: Need for global concern.

Poly- and perfluoroalkyl substances (PFAS) are a class of emerging organic contaminants that are impervious to standard physicochemical treatments. The widespread use of PFAS poses serious environmental issues. PFAS pollution of soils and water has become a significant issue due to the harmful effects of these chemicals both on the environment and public health.

Machine learning-assisted analysis for agronomic dataset of 49 Balangu (Lallemantia iberica L.) ecotypes from different regions of Iran.

The Balangu (Lallemantia iberica) species have a high gastronomical impact in the Middle East and Balkan region. It is widely used in the local food industry, such as confectionery, edible oil, and protein food. In this study, 49 ecotypes were collected from different regions of Iran.

Immunovirotherapy: The role of antibody based therapeutics combination with oncolytic viruses.

Despite the fact that the new drugs and targeted therapies have been approved for cancer therapy during the past 30 years, the majority of cancer types are still remain challenging to be treated. Due to the tumor heterogeneity, immune system evasion and the complex interaction between the tumor microenvironment and immune cells, the great majority of malignancies need multimodal therapy. Unfortunately, tumors frequently develop treatment resistance, so it is important to have a variety of therapeutic choices available for the treatment of neoplastic diseases.

Predictive factors of Sexual Quality of Life in women with polycystic ovary syndrome: a path analysis.

Polycystic ovarian syndrome (PCOS) is one of the common endocrine disorders. This study aimed to assess predictive factors of sexual quality of life among Iranian women with PCOS. A cross-sectional study was conducted on 100 women with PCOS in Hamadan, Iran, from July to October 2021.