Buyang Huanwu Decoction Enhances Revascularization via Akt/GSK3/NRF2 Pathway in Diabetic Hindlimb Ischemia.

Background: Peripheral arterial disease (PAD) is a typical disease of atherosclerosis, most commonly influencing the lower extremities. In patients with PAD, revascularization remains a preferred treatment strategy. Buyang Huanwu decoction (BHD) is a popular Chinese herbal prescription which has showed effects of cardiovascular protection through conducting antioxidant, antiapoptotic, and anti-inflammatory effects.