Publications by authors named "Abdin A"
Purpose: To investigate the morphologic and functional outcomes of nanosecond subthreshold (ST) laser treatment for patients with chronic central serous chorioretinopathy (CSC).
Methods: In this prospective study, 44 patients were treated with the ST nanosecond laser with a follow-up period of 12 months. All target variables were measured at 1, 3, 6 and 12 months after the first laser treatment.
Selenium disulfide (often referred to as SeS) encompasses a family of mixed selenium-sulfide eight-membered rings, traditionally used as an anti-dandruff agent in shampoos. SeS can be produced by reacting hydrogen sulfide (HS) with selenite (SeO) under acidic conditions. This chemistry is also possible with natural spring waters that are rich in HS, thus providing an avenue for the more sustainable, green production of high-quality SeS particles from an abundant natural source.
View Article and Find Full Text PDFRecent years have witnessed a rather controversial debate on what antioxidants are and how beneficial they may be in the context of human health. Despite a considerable increase in scientific evidence, the matter remains highly divisive as different pieces of new data seem to support both the pro- and the anti-antioxidant perspective. Here, we argue that the matter at the heart of this debate is not necessarily empirical but of semantics.
View Article and Find Full Text PDFPurpose: To evaluate the outcome of excimer laser-assisted deep anterior lamellar keratoplasty (Exc-DALK) and penetrating keratoplasty (Exc-PKP) for keratoconus (KC).
Methods: We included 123 eyes and compared the outcome of 30 eyes undergoing big-bubble Exc-DALK after stromal debulking (G1) against a matched group of 83 eyes undergoing Exc-PKP (G2) in our department. G2 was created after performing a pseudorandom stratified bootstrapping of our PKP database starting with 2802 surgeries with removal of any bias.
Aims: To investigate the changes in retinal microvasculature by contemporary imaging techniques during episodes of acute decompensated heart failure (ADHF) and following recompensation compared to age-matched controls without known cardiac or retinal disease.
Methods And Results: Adult patients hospitalized with a primary diagnosis of ADHF, regardless of left ventricular ejection fraction (LVEF) and treated with a minimum dose of 40 mg of intravenous furosemide or equivalent were included. Transthoracic echocardiography was conducted in all patients.
: To investigate the influence of intraretinal fluid (IRF) on change in retinal nerve fiber layer (RNFL) and retinal ganglion cell layer (RGCL) and thickness in patients with naive neovascular AMD under anti-VEGF treatment. : post hoc analysis. : 97 eyes of 83 patients on continuous therapy with intravitreal anti-vascular endothelial growth factors (anti-VEGF) and a follow-up of 24 months were included.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze the impact of dapagliflozin on patients with different QRS durations in heart failure, since longer QRS may lead to poorer outcomes and response to treatment.
- The research pooled data from the DAPA-HF and DELIVER trials, including nearly 10,000 patients with heart failure of varying ejection fractions, and compared event rates of cardiovascular death or worsening heart failure based on QRS duration.
- Findings showed that longer QRS durations correlated with worse outcomes, but dapagliflozin significantly reduced risks across all QRS groups and heart failure types, demonstrating consistent benefits regardless of the QRS duration.
Article Synopsis
- Geographic atrophy (GA) is a serious form of age-related macular degeneration causing irreversible vision loss, characterized by the degeneration of photoreceptors and other retinal structures.
- The study analyzed the progression of GA in 20 eyes from 13 patients over 2.9 years, finding that lesion size increased significantly and most previously unaffected eyes developed subfoveal encroachment (SFE).
- Visual impairment worsened over time, with a notable decrease in best-corrected visual acuity and increased areas of scotoma, indicating a decline in overall macular sensitivity.
Aims: To update the European Society of Cardiology (ESC) quality indicators (QIs) for the evaluation of the care and outcomes of adults with heart failure.
Methods And Results: The Working Group comprised experts in heart failure including members of the ESC Clinical Practice Guidelines Task Force for heart failure, members of the Heart Failure Association, and a patient representative. We followed the ESC methodology for QI development.
To evaluate the impact of excimer laser-assisted deep anterior lamellar keratoplasty (Exc-DALK) and excimer laser-assisted penetrating keratoplasty (Exc-PKP) on subfoveal choroidal thickness (SFCT) in eyes with advanced keratoconus. A retrospective comparative clinical study, which compares the outcomes of 24 eyes treated with Exc-DALK (G1) against matched group of 43 eyes treated with Exc-PKP (G2) at both 2 months (T1) and 2 years (T2) postoperatively. Main outcomes included best-corrected visual acuity (BCVA), central macular thickness (CMT), and SFCT.
View Article and Find Full Text PDFArticle Synopsis
- - The prevalence of heart failure with preserved ejection fraction (HFpEF) is rising, leading to significant hospitalization (up to 80%) and mortality rates (50%) within five years, largely due to systemic inflammation and related cardiac dysfunction.
- - Diagnosing HFpEF is complex and relies on clinical assessments, imaging, biomarkers, and excluding other cardiac conditions that could mimic or contribute to HFpEF.
- - Treatments like sodium-glucose cotransporter 2 inhibitors, tailored therapies, exercise recommendations, and novel inflammation-targeting approaches show promise, especially for obese HFpEF patients who may benefit from glucagon-like peptide-1 agonists.
Bioconversion of organic waste requires the development and application of rather simple, yet robust technologies capable of transferring biomass into energy and sustainable materials for the future. Food waste plays a significant role in this process as its valorisation reduces waste and at the same time avoids additional exploitation of primary resources. Nonetheless, to literally become "litterate".
View Article and Find Full Text PDF: To evaluate the outcomes of intravitreal faricimab (IVF) for refractory neovascular age-related macular degeneration (nAMD) and investigate the impact of baseline optical coherence tomography, biomarkers for total IVF injections are needed. : A retrospective analysis of 33 eyes of patients who completed one year (52 W) of treatment with IVF. The eyes received four IVF injections (6 mg/0.
View Article and Find Full Text PDFShort-term outcomes of intravitreal faricimab for refractory neovascular age-related macular degeneration.
Graefes Arch Clin Exp Ophthalmol
September 2024
Purpose: To assess the short-term outcomes of intravitreal faricimab (IVF) for previously treated refractory neovascular age-related macular degeneration (nAMD) in a real-world setting.
Methods: A retrospective monocentric study including 44 eyes treated with an upload of 4 × monthly intravitreal injections (IVI) of faricimab 6 mg/0.05 mL and followed for 4 weeks after last IVI (16 W).
Purpose: To evaluate the long-term outcome of intravitreal bevacizumab in eyes with diabetic macular oedema (DME) following a PRN (pro re nata) regimen. Additionally, we investigated the effect of the presence of disorganisation of the retinal inner layers (DRILs) and pachychoroid (PC) at baseline on clinical outcome.
Methods: This retrospective study included 112 naïve eyes with DME that were followed up for 2 years.
HFrEF causes significant morbidity and mortality and represents a major public health burden. Recently, there have been significant scientific advances in the treatment of HFrEF, with ARNI, BB, MRA, and SGLT-2i forming the GDMT for HFrEF. Basic quadruple therapy has been shown to significantly reduce of HF hospitalizations, all-cause mortality, and cardiovascular mortality.
View Article and Find Full Text PDFDespite remarkable improvements in the management of heart failure (HF), HF remains one of the most rapidly growing cardiovascular condition resulting in a substantial burden on healthcare systems worldwide. In clinical practice, however, a relevant proportion of patients are treated with suboptimal combinations and doses lower than those recommended in the current guidelines. Against this background, it remains important to identify new targets and investigate additional therapeutic options to alleviate symptoms and potentially improve prognosis in HF.
View Article and Find Full Text PDFArticle Synopsis
- The study examined how fluorescein angiography (FA) affects blood pressure in retinal disease patients, focusing on identifying factors that predict a rise in systolic BP post-procedure.
- A total of 636 patients were monitored for BP and pulse rate before and 20 minutes after undergoing FA, revealing a small overall change in BP, but 16% experienced a significant increase in systolic BP.
- Key findings suggested that older age and the presence of chronic renal failure were associated with a higher likelihood of acute systolic BP elevation after FA, indicating the procedure is generally safe but requires caution in certain patient groups.