Improved Dermal Delivery of Cyclosporine A Loaded in Solid Lipid Nanoparticles.

Cyclosporine A (CsA) is an immunosuppressant frequently used in the therapy of autoimmune disorders, including skin-related diseases. Aiming towards topical delivery, CsA was successfully incorporated into lipid nanoparticles of Lipocire DM and Pluronic F-127 using the hot homogenization method. Two different nanocarriers were optimized: solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) where oleic acid was the liquid lipid.

Uptake of Pb(II) onto nanochitosan/sodium alginate hybrid beads: Mechanism and kinetics study.

Nanochitosan/sodium alginate (NCS/SA) beads were prepared using nanochitosan and alginate as a high-performance absorbent for Pb(II) removal from aqueous solution. The morphology, structure, thermal stability, surface area, and elements present in the NCS/SA beads before and after adsorption were characterized using instrumental techniques like SEM, FTIR, TGA, BET, and EDX analysis, respectively. Various adsorption parameters were studied.