Crystal structure and Hirshfeld surface analysis of -(4-nitro-phen-yl)-2-(piperidin-1-yl)acetamide (lidocaine analogue).

In the title mol-ecule, CHNO, the substituents on the phenyl ring are rotated slightly out of the mean plane of the ring but the piperidine moiety is nearly perpendicular to that plane. In the crystal, C-H⋯O hydrogen bonds form chains of mol-ecules extending along the -axis direction, which are linked by C=O⋯π(ring) inter-actions. A Hirshfeld surface analysis showed the majority of inter-molecular inter-actions to be H⋯H contacts while O⋯H/H⋯O contacts are the second most numerous.

2-Chloro--(4-hy-droxy-phen-yl)acetamide.

The title compound, CHClNO, is significantly distorted from planarity, with a twist angle between the planes through the hy-droxy-benzene and acetamide groups being 23.5 (2)°. This conformation is supported by intra-molecular C-H⋯O and N-H⋯Cl contacts.

Synthesis, crystal structure and Hirshfeld surface of ethyl 2-[2-(methyl-sulfan-yl)-5-oxo-4,4-diphenyl-4,5-di-hydro-1-imidazol-1-yl]acetate (thio-phenytoin derivative).

The di-hydro-imidazole ring in the title mol-ecule, CHNOS, is slightly distorted and the lone pair on the tri-coordinate nitro-gen atom is involved in intra-ring π bonding. The methyl-sulfanyl substituent lies nearly in the plane of the five-membered ring while the ester substituent is rotated well out of that plane. In the crystal, C-H⋯O hydrogen bonds form inversion dimers, which are connected along the - and axis directions by additional C-H⋯O hydrogen bonds, forming layers parallel to the plane.

Synthesis, crystal structure and Hirshfeld surface analysis of 2-[(4-hy-droxy-phen-yl)amino]-5,5-diphenyl-1-imidazol-4(5)-one.

In the title mol-ecule, CHNO, the five-membered ring is slightly ruffled and dihedral angles between the pendant six-membered rings and the central, five-membered ring vary between 50.78 (4) and 86.78 (10)°.

2-[4-(2-Chloro-benz-yl)-3-methyl-6-oxo-1,6-di-hydro-pyridazin-1-yl]--(4-fluoro-phen-yl)acetamide.

The conformation of the title mol-ecule, CHClFNO, is partly determined by an intra-molecular C-H⋯O hydrogen bond, which leads to a dihedral angle of 14.7 (4)° between the fluoro-benzene ring and the acetamide group. The 2-chloro-benzyl group is rotationally disordered over two orientations in a 0.

3-Methyl-2-(methyl-sulfan-yl)-5,5-diphenyl-3,5-di-hydro-4-imidazol-4-one.

In the title mol-ecule, CHNOS, the di-hydro-imidazolone ring is slightly puckered and the methyl-sulfanyl group is nearly coplanar with it. In the crystal, two sets of C-H⋯O hydrogen bonds form corrugated layers of mol-ecules parallel to the plane. The layers pack with normal van der Waals contacts between them.

15,15-Diphenyl-2,3,4,5,6,8,9,11,12-octa-hydro-imidazo[2,1-][1,4,12]trioxa[7]thia-[9]azacyclo-tetra-decin-14(15)-one.

The title mol-ecule, CHNOS, adopts a cup-shaped conformation. In the crystal, layers lying parallel to the plane are formed by C-H⋯O hydrogen bonds and C-H⋯π(ring) inter-actions. The layers stack along the -axis direction through normal van der Waals inter-actions.

3-(2-Bromo-eth-yl)-5,5-di-phenyl-imidazolidine-2,4-dione.

The imidazolidine ring in the title mol-ecule, CHBrNO, is slightly ruffled [r.m.s.

3-Isobutyl-5,5-di-phenyl-imidazolidine-2,4-dione.

The imidazolidine ring in the title mol-ecule, CHNO, is slightly 'ruffled'. In the crystal, a layer structure is generated by N-H⋯O and C-H⋯O hydrogen bonds plus C-H⋯π(ring) inter-actions.

Crystal structure and Hirshfeld surface analysis of 2-chloro--(4-meth-oxy-phen-yl)acetamide.

In the title mol-ecule, CHClNO, the meth-oxy group lies very close to the plane of the phenyl ring while the acetamido group is twisted out of this plane by 28.87 (5)°. In the crystal, a three-dimensional structure is generated by N-H⋯O, C-H⋯O and C-H⋯Cl hydrogen bonds plus C-H⋯π(ring) inter-actions.