Publications by authors named "Abderraouf Radji"
Background: The ZOHé study was a prospective, non-interventional, multicentre study in France to assess the use of biosimilar filgrastim Zarzio® (Sandoz filgrastim) in routine clinical practice in patients at risk of neutropenia-inducing chemotherapy (CT).
Methods: Patients ≥ 18 years undergoing CT for a malignant disease and with a first prescription for Zarzio® were enrolled in two cohorts according to tumour type: solid tumour or haematological malignancy; results from the solid tumour cohort are reported here. Analyses primarily described the prescription and use of Zarzio® in current practice, and also included identification of factors linked to prescription for primary prophylaxis and comparison of Zarzio® use in relation to European Organisation for Research and Treatment of Cancer (EORTC) guidelines.
Article Synopsis
- The study examines the link between post-radiation therapy overreactions (OR) in patients and their clinical radiosensitivity, highlighting the lack of consensus on effective prediction methods since 2003.
- Researchers collected skin biopsy samples from patients with varying degrees of OR, focusing on skin fibroblasts from different sensitivity groups and analyzing their DNA damage response after radiation.
- Findings suggest that OR patients experience a delay in the ATM protein's activity rather than a complete repair defect, leading to a proposed classification of human radiosensitivity into three groups based on their reaction severity.
Context: Patients with gastrointestinal cancer are at high risk for deterioration of nutrition. Home parenteral nutrition (HPN) could improve nutritional status and quality of life (QoL).
Objectives: The purpose of this study was 1) to evaluate the impact of HPN on QoL, 2) to assess changes in nutritional status, and 3) to assess proxy perception of patient well-being.
Malnutrition is a bad prognostic factor that reduces the quality of life (QoL) in patients with cancer. The objective was to assess the impact of home parenteral nutrition (HPN) on the QoL of elderly malnourished patients with cancer. This French prospective observational study included patients, aged 70 years or older, with cancer, for whom HPN was prescribed for at least 14 days.
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