Publications by authors named "Abderrahmane Moundir"
Article Synopsis
- Classical microbiology and immunology have made significant strides in controlling infectious diseases, but recent pandemics like SARS-COV-2 expose limitations in these traditional methods.
- Human genetics plays a crucial role in determining an individual's susceptibility or resistance to infections, influencing how different people react to the same pathogens.
- Integrating genetic insights with microbiology can enhance our understanding of infections and help develop better prevention and treatment strategies.
Article Synopsis
- SARS-CoV-2 causes pneumonia and severe respiratory issues, especially in patients with genetic defects in type I interferon, impacting individuals differently based on age and gender.
- About 3-5% of critical COVID-19 patients under 60 years have genetic defects in interferon production, while around 15-20% of those over 70 show autoantibodies against type I interferons.
- This review discusses the links between genetic and immunological factors contributing to severe COVID-19 and pediatric multisystem inflammatory syndrome (MIS-C), emphasizing the need for more research to develop targeted treatments and strategies for future viral infections.
Introduction: The future of the COVID-19 pandemic depends on the evolution of the virus and immune protection stimulated by vaccination or upon exposure to natural infection. While most research focuses on vaccine efficacy, data remain unclear on the efficacy and duration of natural immune protection against infection.
Aim: In this article, we aim to determine the efficacy of natural immune protection against reinfection with COVID-19 or severe COVID-19.
Article Synopsis
- Genetic testing is crucial for diagnosing inborn errors of immunity (IEI), but high costs and advanced tech limit accessibility, especially in low-income countries like Morocco.
- A study analyzed 742 patients over 12 years, finding that 29% received genetic diagnoses, with 55 defects identified, including 7 new ones.
- Collaborative thesis projects were key to achieving these results, highlighting progress in genetic diagnosis and offering a foundation for better patient care in Morocco.
The International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) reports here the 2022 updated phenotypic classification, which accompanies and complements the most-recent genotypic classification. This phenotypic classification is aimed for clinicians at the bedside and focuses on clinical features and laboratory phenotypes of specific IEI. In this classification, 485 IEI underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity and auto-inflammation are described, including 55 novel monogenic defects and 1 autoimmune phenocopy.
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