Identification of a novel pathogenic variant in and genes by a multigene sequencing panel in triple negative breast cancer in Morocco.

Pathogenic variants (PVs) in genes have been mainly associated with an increasing risk of triple negative breast cancer (TNBC). The contribution of PVs in non-BRCA genes to TNBC seems likely since the processing of homologous recombination repair of double-strand DNA breaks involves several genes. Here, we investigate the susceptibility of genetic variation of the and non- genes in 30 early-onset Moroccan women with TNBC.

Pulmonary tumor diagnosed as an undifferentiated sarcoma with epithelioid features: a case report.

Background: Pulmonary sarcomas are uncommon accounting for 0.5 % of all primary lung cancers. Undifferentiated sarcomas account for up to 20 % of soft tissue sarcomas.

Bone metastasis from malignant phyllodes breast tumor: report of two cases.

Background: Phyllodes tumors are rare fibroepithelial tumors accounting for less than 1 % of all breast neoplasms. They are malignant in 20 % of cases. Only a few cases of malignant phyllodes tumors metastatic to bone have been reported.

Primary leiomyosarcoma of the submandibular gland: a case report.

Background: Leiomyosarcoma is a rare malignant mesenchymal tumor that represents 5-7 % of all soft tissue sarcomas. The occurrence of this tumor in the salivary glands is exceptional. Only five cases are reported in the submandibular gland.

Diagnosis and management challenge of a granular cell astrocytoma of the pineal region: case report.

Granular cell astrocytoma (GCA) is a rare type of infiltrative brain tumor with most reported cases occurring in the suprasellar region. A pineal localization is extremely rare, with only 4 previously reported cases in the literature. The authors describe the case of a 16-year-old boy who developed signs of increased intracranial pressure and Parinaud syndrome.