Publications by authors named "Abdelrhman M Abumoawad"
Introduction: Catheter ablation (CA) for atrial fibrillation (AF) can be associated with limited efficacy. Due to its autonomic innervation, the vein of Marshall (VOM) is an attractive target during AF ablation. In this meta-analysis, we aimed to evaluate the efficacy and safety of adjunctive ethanol infusion of VOM (VOM-EI) in AF ablation.
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- Hybrid convergent procedure (HCP) for atrial fibrillation (AF) shows better success in maintaining freedom from arrhythmias compared to traditional endocardial catheter ablation (ECA).
- Despite its efficacy, HCP is linked to a higher risk of complications and involves longer procedure times and hospital stays.
- Future research through large-scale randomized trials is essential to further assess the safety and effectiveness of HCP in AF treatment.
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- Atherosclerotic renal artery stenosis (ARAS) negatively affects the function of mesenchymal stem cells (MSCs), making them less effective for potential therapies, but hypoxia preconditioning (HPC) could improve their function through epigenetic changes.
- In an experiment, MSCs from healthy and ARAS pigs were tested under normal and hypoxic conditions, measuring factors like migration, proliferation, and gene expression.
- Results indicated that HPC enhanced the ability of ARAS MSCs to migrate and proliferate, increased certain pro-angiogenic factors, and decreased markers of cellular senescence, suggesting HPC could be a beneficial strategy for improving MSC therapies in ARAS patients.
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- Cell stress can lead to cellular senescence, which is a state of permanent growth arrest, and this may occur in stenotic kidneys due to renal artery stenosis (RAS).
- The study investigated whether mesenchymal stem cells (MSCs) could alleviate the effects of RAS-induced senescence in a mouse model and in humans with renovascular hypertension.
- Results showed that while MSCs improved kidney function and reduced some injuries, they only partially reduced markers of senescence, indicating that targeted therapies may be needed for better senolytic effects in RAS.
Article Synopsis
- * Researchers studied patients with essential and renovascular hypertension, finding that urine from these patients had higher levels of p16+ EVs, a marker for cell aging, compared to healthy individuals.
- * The presence of p16 in urine correlated with kidney function and inflammatory markers, suggesting that measuring these EVs could help identify specific areas of kidney damage in hypertensive patients.
Rationale And Objectives: Multidetector computed tomography (MDCT) is useful for measuring in the research setting single-kidney perfusion and function using iodinated contrast time-attenuation curves. Obesity promotes deposition of intrarenal fat, which might decrease tissue attenuation and thereby interfere with quantification of renal function using MDCT. The purpose of this study was to test the hypothesis that background subtraction adequately accounts for intrarenal fat deposition in mildly obese human subjects during renal contrast enhanced dynamic CT.
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