Breast cancer stands out as the most frequently identified malignancy, ranking as the fifth leading cause of global cancer-related deaths. The American College of Radiology (ACR) introduced the Breast Imaging Reporting and Data System (BI-RADS) as a standard terminology facilitating communication between radiologists and clinicians; however, an update is now imperative to encompass the latest imaging modalities developed subsequent to the 5th edition of BI-RADS. Within this review article, we provide a concise history of BI-RADS, delve into advanced mammography techniques, ultrasonography (US), magnetic resonance imaging (MRI), PET/CT images, and microwave breast imaging, and subsequently furnish comprehensive, updated insights into Molecular Breast Imaging (MBI), diagnostic imaging biomarkers, and the assessment of treatment responses.
View Article and Find Full Text PDFThe objective was to clarify the impact of replacing cottonseed meal with canola meal (CM) on growth performance, blood metabolites, thyroxin function, and ruminal parameters of growing lambs. Twenty-four growing Barki male lambs (4-5 months of age) were assigned randomly into four equal groups (6 lambs each). Four dietary treatments were the control group with 0% CM (CON) and three experimental groups where CM replaced 25% (CN), 50% (CN), and 75% (CN) of cottonseed meal.
View Article and Find Full Text PDFThe various sources of supplemented copper had a different impact on the animal performance based on their bioavailability. The current study compared the effects of supplementary copper oxide (CuO), copper acetate (Cu-acetate) and copper nanoparticles (Cu-NP) on performance, immune function, nutrients digestibility and architecture of the liver and kidney of growing rabbits for eight weeks. Sixty rabbits (581 ± 6.
View Article and Find Full Text PDFThe use of Monosodium Glutamate (MSG) as a food flavor enhancer is increasing worldwide despite its neurotoxic effects. Fluoxetine (FLX) and Rosemary extract (RE) are known to have beneficial neuroprotective properties. Rats were divided into five groups: control group; MSG group, rats received 2 g∕kg∕day intraperitoneal (i.
View Article and Find Full Text PDFAn 8-week experiment was carried out to assess the impact of supplemental dietary pyridoxine (PY), protease (PR), zinc (Zn) and their mixture (MIX) with low protein diet (LP; 14.76% CP) or high protein diet (HP; 18.53% CP) on rabbit growth, feed utilization, and nutrients digestibility.
View Article and Find Full Text PDFCultural, environmental and logistical factors challenge the Qatari population, particularly females, to engage in physical activity, and there is a high prevalence of diabetes in this population. Sedentary behavior is associated with increased cardiometabolic disease risk and early mortality and breaking up sitting can attenuate postprandial cardiometabolic risk markers. However, no studies have evaluated the cardiometabolic response to breaking up sitting in a Qatari population.
View Article and Find Full Text PDFBackground: Triple negative breast cancer (TNBC) easily develops resistance to the first-line drug doxorubicin, because of the high levels of the drug efflux transporter P-glycoprotein (Pgp) and the activation of pro-survival pathways dependent on endoplasmic reticulum (ER). Interfering with these mechanisms may overcome the resistance to doxorubicin, a still unmet need in TNBC.
Methods: We analyzed a panel of human and murine breast cancer cells for their resistance to doxorubicin, Pgp expression, lysosome and proteasome activity, nitrite production, ER-dependent cell death and immunogenic cell death parameters.
The objectives of this study were to evaluate the effects of pretreating dairy cow rations with a fibrolytic enzyme derived from Trichoderma reesei (FETR; mixture of xylanase and cellulase; AB Vista, Wiltshire, UK) on lactation performance, digestibility, and feeding behavior in response to feeding a barley silage-based diet. Before starting the dairy trial, in vitro incubations were conducted to determine whether the addition of FETR would have an effect on these animal performance characteristics when applied to a barley silage-based diet for dairy cows. The dairy trial was performed using 8 Holstein dairy cows.
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