Publications by authors named "Abdelouahad Oussaid"
Article Synopsis
- Two new chalcone-based imidazothiazole derivatives were synthesized and characterized using advanced techniques, confirming their structure through X-ray diffraction.
- The compounds demonstrated significant antiproliferative effects on various cancer cell lines (like MCF-7, A-549, and HT-29), while showing less effect on healthy 3T3-L1 cells, indicating a preference for cancerous over healthy cells.
- Studies revealed that these compounds induce apoptosis in cancer cells through mitochondrial disruption and caspase activation, with potential implications as effective anticancer drug candidates, supported by molecular docking studies and pharmacokinetic analysis.
A new library of N,N,N',N' -tetradentate pyrazoly compounds containing a pyrazole moiety was synthesized by the condensation of (3,5-dimethyl-1H-pyrazol-1-yl)methanol 2a or (1H-pyrazol-1-yl)methanol 2b with a series of primary diamines in refluxed acetonitrile for 6h. The antifungal activity against the budding yeast Saccharomyces cerevisiae, as well as the antibacterial activity against Escherichia coli of these new tetradentate ligands were studied. We found that these tetradentate ligands act specifically as antifungal agents and lack antibacterial activity.
View Article and Find Full Text PDF