Publications by authors named "Abdelmohsen U"

Mucormycosis, a life-threatening fungal infection caused by Mucorales, affects immunocompromised patients, especially SARS-CoV-2 ones. Existing antifungal therapies, like amphotericin B, have serious health risks. The current study reviews the literature regarding an overview of SARS-CoV-2-associated mucormycosis, along with different terpenes from diverse edible sources such as basil, ginger, and clove, which are detected till June 2024.

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  • The ethyl acetate extract from the endophytic fungus Aspergillus terreus found in Artemisia arborescens L. led to the discovery of five new compounds, asperterreunolides A-E, along with a known metabolite, butyrolactone IV.
  • Using advanced spectroscopic techniques, the researchers determined the structures and the absolute configurations of these metabolites.
  • All isolated compounds exhibited significant cytotoxic effects against certain cancer cell lines, and molecular docking studies suggested their potential mechanism of action as inhibitors of type IIA topoisomerase.
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  • The study identified sixteen compounds from the ethyl acetate extract of seeds related to a specific species and evaluated the wound-healing effects of a combination of BMMSCs and this extract in immunocompromised rats.
  • The combination therapy was found to reduce oxidative stress, lower pro-inflammatory cytokines, and inhibit NF-KB activation after 16 days.
  • Key genes linked to wound healing were identified, with pathways indicating positive effects on cell migration and locomotion, highlighting the potential of this approach in regenerative medicine, though further safety tests and clinical trials are needed.
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Methotrexate (MTX) is commonly employed in cancer treatment, but its clinical use is restricted due to the MTX-associated renal injury. This study investigates the combined potential of Rhus coriaria (sumac) and bone marrow mesenchymal stem cells (BMMSCs) against MTX-induced nephrotoxicity in rats. The high-resolution-liquid chromatography-mass spectrometry (HR-LC-MS) of sumac extract tentatively identified 22 phytochemicals, mostly flavonoids, anthocyanins, and steroids.

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Bioassay-guided fractionation approach led to identification of two novel compounds; (4-(hydroxymethyl)-3-methoxy-1H-pyrazol (1) and mycalene (2), alongside with four known metabolites; octadecane (3), hexatriacontane (4), 1-heneicosanol (5) and heptatriacontanoic acid (6) from the Red Sea marine sponge Hemimycale sp. The ethyl acetate fraction showed a noticeable cytotoxic activity against the lung cancer cell line (A549) with IC value of 75.54 µg/ mL.

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Background: Sponge-associated microorganisms are promising resources for the production of bioactive compounds with cytotoxic potential. The main goal of our study is to isolate the fungal endophytes from the Red Sea sponge Hyrtios sp. followed by investigating their cytotoxicity against number of cell lines.

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The emergence of antibiotic-resistant necessitates the discovery of novel therapeutic agents. This study investigated the antimicrobial potential of green-synthesized gold nanoparticles (AuNPs) fabricated using extract. Characterization using Fourier transform infrared spectroscopy revealed the presence of functional groups such as ketones, aldehydes, and carboxylic acids in the capping agents, suggesting their role in AuNP stabilization.

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  • - The study investigates the neuroprotective effects of Lobophytum sp. crude extract in a rat model designed to mimic Parkinson's disease, focusing on its impact on oxidative stress, inflammation, and apoptosis markers.
  • - A detailed metabolomic analysis using HR-LC-ESI-MS identified 20 secondary metabolites in the extract, highlighting potential therapeutic compounds against neurodegeneration.
  • - The research suggests that the extract may mitigate neurodegeneration by reducing harmful factors and enhancing neuroprotective proteins, with a prominent link established between specific compounds and Parkinson's-related genes and pathways.
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Background: Breast cancer is the most diagnosed cancer in women. Its pathogenesis includes several pathways in cancer proliferation, apoptosis, and metastasis. Some clinical data have indicated the association between coffee consumption and decreased cancer risk.

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Liposomes and niosomes can be considered excellent drug delivery systems due to their ability to load all compounds, whether hydrophobic or hydrophilic. In addition, they can reduce the toxicity of the loaded drug without reducing its effectiveness. sp.

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Environmentally friendly biosynthesis of silver nanoparticles (AgNPs) from (L.) Webb & Berthel is reported for the first time. The synthesized AgNPs were characterized using UV-Vis, FTIR, TEM, Zeta potential, and XRD analysis, revealing high stability (-29.

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Green seaweed (Ulva sp.) is frequently used as a food component and nutraceutical agent because of its high polysaccharide and natural fiber content in Asian countries. This study investigates both metabolomic profiling of Ulva sp.

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The aim of this study is to evaluate the anti-HPV potential of a Lam seed, L. seed, and peel herbal mixture in the form of polymer film-forming systems. A clinical trial conducted in outpatient clinics showed that the most significant outcome was wart size and quantity.

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  • - The study tested the antibacterial effects of root extracts from Jasminum officinale, Rosa damascena, and Paeonia officinalis against MRSA, finding that P. officinalis had significant efficacy with a minimum inhibitory concentration (MIC) of 0.4673 µg/ml, while the other two showed minimal activity.
  • - Chemical profiling of P. officinalis revealed 20 different metabolites, primarily terpenes, and network pharmacology was utilized to map these metabolites' targets related to MRSA infections, using various online databases and software tools.
  • - The research identified 254 targets associated with MRSA, with several key genes linked to the infection and highlighted the vascular smooth muscle contraction pathway as the top
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Osteoarthritis (OA) is a degenerative joint disease, characterized by infiltration of monocytes into the synovial joint which promotes inflammation, stiffness, joint swelling, cartilage degradation and further bone destruction. The leaves of have been used for inflammation-related disease management in traditional medicine. Additionally, the downregulation of NF-κB and the MMP/TIMP-1 ratio has been shown to protect against OA.

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  • Scientists studied fungi from plants to find out if they can help create useful substances.
  • They tested three types of fungi from different parts of the plants and mixed them with various chemicals to see how they would grow.
  • The results showed that certain chemicals made the fungi produce compounds that could potentially fight breast cancer cells.
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  • This study is the first to profile the metabolites of a wild desert plant from the Amaranthaceae family using LC-QTOF-MS/MS, identifying 66 known compounds including catecholamines, phenolic acids, and a novel tyramine derivative.
  • The research addresses taxonomical challenges within the genus by providing insights into the plant's chemical fingerprint and its phylogenetic relationships with other species.
  • The methanolic extract of the plant showed antibacterial properties, with a minimum inhibitory concentration ranging from 32 to 256 μg/mL, and significantly reduced biofilm formation and violacein production, attributed to specific compounds binding to a transcriptional activator.
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Wound healing, one of the most intricate and dynamic processes of the body, maintains skin integrity following trauma. One of the main issues that still exists is impaired wound healing, particularly for immunosuppressed patients. Recently, natural products from marine environments have been employed in wound-repairing activities.

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  • Cancer is a leading global cause of death, and a major obstacle in treatment is multidrug resistance (MDR) in tumors.
  • Recent research has shown that compounds derived from natural products, like flavonoids and alkaloids, can potentially reverse MDR.
  • This review discusses past successes and current advancements in using natural products as treatments, aiming to contribute insights into combating MDR in cancer therapy.
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  • Scientists studied the peels of Key limes and found six special chemicals inside them.
  • Three of these chemicals, limonin, luteolin, and myricetin, were really good at fighting the malaria-causing parasite.
  • They think these lime peels could help create new medicines to treat malaria safely and effectively.
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Background: Gastric ulcers represent a worldwide health problem, characterized by erosions that affect the mucous membrane of the stomach and may even reach the muscular layer, leading to serious complications. Numerous natural products have been assessed as anti-ulcerogenic agents, and have been considered as new approaches for treatment or prevention of gastric ulcers. The present research investigated the preventive benefits of Apium graveolens L.

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The in-vitro anti-proliferative evaluation of Sinularia levi total extract against three cell lines revealed its potent effect against Caco-2 cell line with IC50 3.3 μg/mL, followed by MCF-7 and HepG-2 with IC50 6.4 μg/mL and 8.

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