Oxidant-Induced Azolation of Electron-Rich Phenol Derivatives.

Since -arylazoles are widely present in natural products, pharmaceuticals, and functional materials, it is important to develop a simple and efficient synthetic method for the synthesis of -arylazoles. Herein, an oxidant-induced intermolecular azolation of phenol derivatives was demonstrated under catalyst-free condition. Both monoazolation and diazolation of phenols can be successfully achieved via this practical and powerful method.

Electrooxidation enables highly regioselective dearomative annulation of indole and benzofuran derivatives.

The dearomatization of arenes represents a powerful synthetic methodology to provide three-dimensional chemicals of high added value. Here we report a general and practical protocol for regioselective dearomative annulation of indole and benzofuran derivatives in an electrochemical way. Under undivided electrolytic conditions, a series of highly functionalized five to eight-membered heterocycle-2,3-fused indolines and dihydrobenzofurans, which are typically unattainable under thermal conditions, can be successfully accessed in high yield with excellent regio- and stereo-selectivity.

Identification of novel antifungal agents: antimicrobial evaluation, SAR, ADME-Tox and molecular docking studies of a series of imidazole derivatives.

Thirty-four imidazole-based compounds synthesized by one-pot catalytic method were evaluated for their antifungal and antibacterial activities against several fungal and bacterial strains. None of the compounds had antibacterial activity. Interestingly, compounds , , , and displayed a strong antifungal activity against all the tested fungal species, while compounds , , , , and showed a moderate antifungal activity.

Recent Advances in Oxidative R-H/R-H Cross-Coupling with Hydrogen Evolution via Photo-/Electrochemistry.

Photo-/electrochemical catalyzed oxidative R-H/R-H cross-coupling with hydrogen evolution has become an increasingly important issue for molecular synthesis. The dream of construction of C-C/C-X bonds from readily available C-H/X-H with release of H can be facilely achieved without external chemical oxidants, providing a greener model for chemical bond formation. Given the great influence of these reactions in organic chemistry, we give a summary of the state of the art in oxidative R-H/R-H cross-coupling with hydrogen evolution via photo/electrochemistry, and we hope this review will stimulate the development of a greener synthetic strategy in the near future.

In vitro screening, homology modeling and molecular docking studies of some pyrazole and imidazole derivatives.

A series of synthesized compounds based on pyrazole and imidazole skeletons prepared by palladium catalysts via a one-pot reaction was screened to determine their inhibitory potency against the pathogen fungus Fusarium oxysporum f.sp. albedinis (F.

New N,N,N',N'-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities.

A new library of N,N,N',N' -tetradentate pyrazoly compounds containing a pyrazole moiety was synthesized by the condensation of (3,5-dimethyl-1H-pyrazol-1-yl)methanol 2a or (1H-pyrazol-1-yl)methanol 2b with a series of primary diamines in refluxed acetonitrile for 6h. The antifungal activity against the budding yeast Saccharomyces cerevisiae, as well as the antibacterial activity against Escherichia coli of these new tetradentate ligands were studied. We found that these tetradentate ligands act specifically as antifungal agents and lack antibacterial activity.