Prosthetic polyester-based hybrid mesh for repairing of perineal hernia in dogs.

Background: This study involves the use of a new multifunctional prosthetic mesh for treatment of the perineal hernia without complications. The prosthetic mesh is a hybrid platform of both synthetic and natural materials, mainly consisting of a synthetic commercial polyester fabric (CPF) to deliver the required mechanical integrity. The CPF mesh was coated by a natural biodegradable, biocompatible, and antimicrobial layer of chitosan incorporating phenytoin-loaded pluronic nanomicelles for healing promotion and ciprofloxacin-alginate polyelectrolyte complex-based microparticles as antibacterial agent.