Correction: Selim et al. Impact of Leaves on Gamma Irradiation-Induced Hepatotoxicity in Rats and Correlation with STING Pathway and Phenolic Composition. 2020, , 320.

In the original publication [...

Growth, Biochemical Traits, Antioxidant Enzymes, and Essential Oils of Four Aromatic and Medicinal Plants Cultivated in Phosphate-Mine Residues.

Revegetation emerges as a promising approach to alleviate the adverse impacts of mining residues. However, it is essential to evaluate the characteristics of these materials and select suitable plant species to ensure successful ecosystem restoration. This study aimed to investigate the effects of phosphate-mine residues (MR) on the growth, biochemical properties, and essential oil concentration of L.

Thymoquinone Alleviates Cadmium Induced Stress in Germinated Seeds by Reducing Oxidative Stress and Increasing Antioxidative Activities.

This study investigated the effect of thymoquinone on seeds germination and young seedlings of lentils under cadmium (Cd) stress (300 µM). Three different concentrations (10 µM, 1 µM, and 0.1 µM) of thymoquinone were applied.

Insecticidal Activities of L., Spenn. and L. against (Cockerell) under Laboratory and Greenhouse Conditions.

The wild cochineal (Hemiptera: Dactylopiidae) is one of the major insect pests of the prickly pear (L.) in Morocco, a well-known fruit and vegetable crop of arid and semi-arid regions around the world. The present study investigated the insecticidal potential of six extracts (three aqueous and three hydroalcoholic (MeOH/HO, 20/80 (/)) from (leaves), (leaves) and (seeds) to control nymphs and adult females of under laboratory and greenhouse conditions.

Box-Behnken Design: Wet Process Optimization for Saponins Removal From Seeds and the Study of Its Effect on Nutritional Properties.

The pseudocereal grain, Quinoa ( Willd.), has a great nutritional value due to its high contents of proteins, fiber, minerals, and vitamins. However, saponins naturally present outside the grains represent an obstacle to their consumption as human food.

Extract as a Biostimulant to Enhance Tolerance to Salinity in Tomato Plants.

Salinity is a severe abiotic problem that has harmful impacts on agriculture. Recently, biostimulants were defined as bioprotectant materials that promote plant growth and improve productivity under various stress conditions. In this study, we investigated the effect of Crataegus oxyacantha extract as a biostimulant on tomato plants (Solanum lycopersicum) grown under salt stress.

(Mart.) Solms: A Comprehensive Review of Its Chemical Composition, Traditional Use, and Value-Added Products.

(Mart.) Solms, commonly known as water hyacinth, is one of the world's most invasive aquatic plants of the Pontederiaceae family occurring in tropical and subtropical regions of the world. Although, causes significant ecological and socioeconomic issues such as a high loss in water resources, it has multipurpose applications since it is famous for many industrial applications such as bioenergy, biofertilizer production, wastewater treatment (absorption of heavy metals), and animal feed.

Functional properties of chitosan derivatives obtained through Maillard reaction: A novel promising food preservative.

This review provides an insight about the functional properties of chitosan obtained through Maillard reaction to enhance the shelf life and food quality. Maillard reaction is a promising and safe method to obtain commercial water-soluble chitosan's through Schiff base linkage and Amadori or Heyns rearrangement. Likewise, chitosan derivatives exert an enhanced antimicrobial, antioxidant, and emulsifying properties due to the development of Maillard reaction products (MRPs) like reductones and melanoidins.

A Polyphenol-Rich Extract From Reduces Oxidative Damage in Cryopreserved Ram Semen.

The Splinter bean, , is widely used in folk medicine. In the current work, we profiled the secondary metabolites from bark extract using LC-MS and investigated its effect on cryopreserved ram semen. Twenty-eight compounds, including tannins and gallic acid derivatives that prevailed in the extract, were tentatively identified.

A Polyphenols-Rich Extract from Boiss. Exhibits Analgesic, Anti-Inflammatory and Antipyretic Activities In Vivo.

In this study, the aerial parts of were evaluated for their in vivo analgesic, anti-inflammatory and antipyretic activities. The analgesic activities were examined using acetic acid-induced writhing, the hot plate test and the tail flick method. The anti-inflammatory and the antipyretic activities were evaluated using carrageenan-induced paw edema in rats and brewer's yeast-induced pyrexia in mice, respectively.

Impact of Leaves on Gamma Irradiation-Induced Hepatotoxicity in Rats and Correlation with STING Pathway and Phenolic Composition.

Exposure to ionizing radiation usually results in cellular oxidative damage and may induce liver toxicity. The efficiency of the ethanol extracts of (EWF) and (EWR) leaves in alleviating γ-radiation-induced oxidative hepatotoxicity was herein explored. Proximate and macronutrient composition of the leaves was determined to establish reliable quality control criteria.

Chemically degraded soil rehabilitation process using medicinal and aromatic plants: review.

In recent decades, the increasing number of degraded lands worldwide makes their rehabilitation essential and crucial. Various techniques have emerged to fulfill these needs but most of them are expensive and difficult to be applied. Revegetation is a cost effective, environmental friendly, and aesthetically pleasing approach suitable for degraded areas.

Variations of Saponins, Minerals and Total Phenolic Compounds Due to Processing and Cooking of Quinoa ( Willd.) Seeds.

Quinoa ( Willd.) is a grain of great nutritional interest that gained international importance during the last decade. Before its consumption, this grain goes through many processes that can alter its nutritional value.

and : Chemical Composition, In Vivo Antiinflammatory, Pain Killing and Antipyretic Activities: A Comprehensive Comparison.

This study aimed to investigate the chemical composition, and evaluate the antioxidant, anti-inflammatory, anti-pyretic, and the analgesic properties of methanol extracts from the leaves of (Lamiaceae). Thirty-five secondary metabolites were characterized in both extracts using HPLC-PDA-ESI-MS/MS. Phenolic acids, mainly rosmarinic acid and its derivatives, dominated the extract, while the phenolic diterpene carnosol and the methylated flavonoid salvigenin, prevailed in extract.

Polyphenols from Impair Virulence and Inhibit Quorum Sensing of .

Bacterial resistance represents one of the emerging obstacles in plants, animals, and humans that impairs treatment with antibacterial agents. Targeting of the bacterial quorum sensing system is one of the strategies to overcome this problem. Recently, research has been focused on natural and food components which can function as quorum sensing inhibitors.

An Insight into Saponins from Quinoa ( Willd): A Review.

Saponins are an important group found in . They represent an obstacle for the use of quinoa as food for humans and animal feeds because of their bitter taste and toxic effects, which necessitates their elimination. Several saponins elimination methods have been examined to leach the saponins from the quinoa seeds; the wet technique remains the most used at both laboratory and industrial levels.

Combining a QSAR Approach and Structural Analysis to Derive an SAR Map of Lyn Kinase Inhibition.

Lyn kinase, a member of the Src family of protein tyrosine kinases, is mainly expressed by various hematopoietic cells, neural and adipose tissues. Abnormal Lyn kinase regulation causes various diseases such as cancers. Thus, Lyn represents, a potential target to develop new antitumor drugs.

Petroleum sludge bioremediation and its toxicity removal by landfill in gunder semi-arid conditions.

In this investigation, petroleum sludge landfilling was carried out in order to assess the biodegradation degree and the final product quality. The microbial analysis showed a good microorganism proliferation which reinforces the biodegradation process. The total mesophilic and thermophilic microflora evaluated symmetrically as they increased at the intermediate stage and decreased at the final.

Discovering novel 7-azaindole-based series as potent AXL kinase inhibitors.

AXL is a receptor tyrosine kinase that plays a key role in tumor growth and proliferation. The scientific community has validated AXL as therapeutic target in the treatment of cancers for several years now, and several AXL inhibitors have been developed but none of them are approved. In this context, we started to design new kinase inhibitors targeting AXL from the 7-azaindole scaffold well known to interact with the ATP binding site of the kinase.

Structure-activity relationships study of mTOR kinase inhibition using QSAR and structure-based drug design approaches.

The discovery of clinically relevant inhibitors of mammalian target of rapamycin (mTOR) for anticancer therapy has proved to be a challenging task. The quantitative structure-activity relationship (QSAR) approach is a very useful and widespread technique for ligand-based drug design, which can be used to identify novel and potent mTOR inhibitors. In this study, we performed two-dimensional QSAR tests, and molecular docking validation tests of a series of mTOR ATP-competitive inhibitors to elucidate their structural properties associated with their activity.

Rational Design, Synthesis, and Biological Evaluation of 7-Azaindole Derivatives as Potent Focused Multi-Targeted Kinase Inhibitors.

Efforts were made to improve a series of potent dual ABL/SRC inhibitors based on a 7-azaindole core with the aim of developing compounds that demonstrate a wider activity on selected oncogenic kinases. Multi-targeted kinase inhibitors (MTKIs) were then derived, focusing on kinases involved in both angiogenesis and tumorigenesis processes. Antiproliferative activity studies using different cellular models led to the discovery of a lead candidate (6z) that combined both antiangiogenic and antitumoral effects.

Determination and validation of mTOR kinase-domain 3D structure by homology modeling.

The AKT/mammalian target of rapamycin (mTOR) pathway is considered as one of the commonly activated and deregulated signaling pathways in human cancer. mTOR is associated with other proteins in two molecular complexes: mTOR complex 1/Raptor and the mTOR complex 2/Rictor. Using the crystal structure of the related lipid kinase PI3Kγ, we built a model of the catalytic region of mTOR.