Publications by authors named "Abdelaziz Mekhalfia"
Article Synopsis
- Hint protein is an enzyme that helps break down AMP and plays a role in regulating RNA polymerase II in yeast.
- Researchers created new substrates and inhibitors to study how the rabbit version of Hint works, finding that one inhibitor binds significantly better than another.
- A detailed 1.8-A crystal structure of Hint with the better binding inhibitor revealed specific interactions at the binding site that are essential for the enzyme's catalytic function.
1. Heteromeric P2X2/3 receptors are much more sensitive than homomeric P2X2 receptors to alphabeta-methylene-ATP, and this ATP analogue is widely used to discriminate the two receptors on sensory neurons and other cells. 2.
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