Alopecia Management Potential of Rosemary-Based Nanoemulgel Loaded with Metformin: Approach Combining Active Essential Oil and Repurposed Drug.

Introduction: Androgenetic alopecia (AGA) is a multifactorial and age-related dermatological disease that affects both males and females, usually at older ages. Traditional hair repair drugs exemplified by minoxidil have limitations such as skin irritation and hypertrichosis. Thus, attention has been shifted to the use of repurposing drugs.

Comparative phytochemical and pharmacological analysis of two cultivars of Annona squamosa L. cultivated in Egypt.

This study compared two Annona squamosa L. cultivars, Abdelrazik (Annona A.) and Balady (Annona B.

Facile green synthesis of silver doped NiO nanoparticles using aloe vera latex for efficient energy storage and photocatalytic applications.

Herein, we report the biosynthesis of pure NiO and NiO nanoparticles doped with Silver (Ag@NiO NPs) 2, 4, 6, and 8 mol% from aloe vera extract by solution combustion method at 400 °C and calcined at 500 °C for 3 h. By utilizing silver-doped NiO nanoparticles synthesized with Aloe Vera latex, which not only enhances the material's properties but also promotes environmentally friendly fabrication methods. The morphological, structural elemental compositions were analysed through SEM, HRTEM, SAED, XRD and EDAX.

Mitigating Oxidative Stress and Promoting Cellular Longevity with Mushroom Extracts.

Oxidative stress can disrupt the body's ability to fight harmful free radicals, leading to premature aging and various health complications. This study investigated the antioxidant and anti-aging properties of four medicinal and edible mushrooms: , , , and . The antioxidant activity of mushroom extracts was evaluated using (DPPH-ABTS-Reducing power).

Exploring ultrasound and electromyography for carpal tunnel syndrome diagnosis: a comprehensive comparative study and implications for occupational medicine.

Background: To assess the contribution of ultrasound in diagnosing occupational carpal tunnel syndrome (CTS), compare it with electromyography (EMG) results, and evaluate the ultrasound characteristics of CTS patients.

Methods: A nine-month cross-sectional study (January-September 2021) involved CTS patients and a control group, utilizing a structured form for data collection. EMG was performed on the patient group ('cases') and ultrasound examinations were conducted on both groups.

Comprehensive evaluation of using mineral and bio phosphorus fertilization on orange tree () productivity.

Phosphorus (P) is considered as an essential element in crop production. Besides, the study of P from the elemental and bio sources impacts on productivity and quality of orange trees could emphasize its utilization importance. This study aimed to evaluate the chemical implication of three treatments of P fertilization (Triple phosphate (TP; 620 and 900 g/tree/year), phosphate rock (PR; 1820 and 2742 g/tree/year) and 1:1 TP:PR on Valencia orange trees ( L.

Limb-belt resisted sprint training improves physical fitness and ball-throw velocity in pubertal handball players.

The study assessed the effect of six weeks of biweekly upper and lower limbs' weighted-belt resisted sprint training (BRST) and weighted-vest resisted sprint training (VRST), or normal sprint training (NST) on muscle strength, speed, change of direction and handball-throwing velocity in young handball players. Twenty-seven pubertal male handball players aged 14.4 years were randomly assigned into BRST (n = 9), VRST (n = 8), and NST (n = 8) groups.

Oleuropein Relieves Pancreatic Ischemia Reperfusion Injury in Rats by Suppressing Inflammation and Oxidative Stress through HMGB1/NF-κB Pathway.

Oleuropein (OLP) is a naturally occurring phenolic compound in olive plant with antioxidant and anti-inflammatory potential and can possibly be used in treating pancreatic injuries. This investigation aimed to follow the molecular mechanism behind the potential therapeutic effect of OLP against pancreatic injury persuaded by ischemia-reperfusion (I/R). Pancreatic I/R injury was induced by splenic artery occlusion for 60 min followed by reperfusion.

Efficient lung cancer detection using computational intelligence and ensemble learning.

Lung cancer emerges as a major factor in cancer-related fatalities in the current generation, and it is predicted to continue having a long-term impact. Detecting symptoms early becomes crucial for effective treatment, underscoring innovative therapy's necessity. Many researchers have conducted extensive work in this area, yet challenges such as high false-positive rates and achieving high accuracy in detection continue to complicate accurate diagnosis.

Thymol and carvacrol derivatives as anticancer agents; synthesis, activity, and computational analysis of biological targets.

Various thymol and carvacrol derivatives have been synthesized to test the anticancer activity potential. Computational methods including network pharmacology and molecular docking approaches were utilized to identify and assess the potential biological targets relating to cancer. Amongst the synthesized derivatives the ethoxy-cyclohexyl analogues were consistently the most active against a panel of 10 different cancer cell lines covering a variety of origins.

Software-Defined-Networking-Based One-versus-Rest Strategy for Detecting and Mitigating Distributed Denial-of-Service Attacks in Smart Home Internet of Things Devices.

The number of connected devices or Internet of Things (IoT) devices has rapidly increased. According to the latest available statistics, in 2023, there were approximately 17.2 billion connected IoT devices; this is expected to reach 25.

Metabolomic Profiling and In Vivo Antiepileptic Effect of Aerial Parts and Roots Crude Extracts against Pentylenetetrazole-Induced Kindling in Mice.

The chemical profiles of both () aerial parts and roots extracts were evaluated with LC-ESI-TOF-MS/MS analysis. Twenty-four compounds were detected. Among them, some are detected in both the aerial parts and the roots extracts, and others were detected in the aerial parts only.

Structural, radiation shielding, thermal and dynamic mechanical analysis for waste rubber/EPDM rubber composite loaded with FeO for green environment.

Increasing waste rubber recycling produces a specious range of products for many valuable applications. Waste Rubber/EPDM composite with different concentrations was prepared. Infrared spectroscopy (FTIR) is used to identify the chemical composition.

Clinical reappraisal of the composite international diagnostic interview version 3.3 in Qatar's National Mental Health Study.

Objectives: Lifetime DSM-5 diagnoses generated by the lay-administered Composite International Diagnostic Interview for DSM-5 (CIDI) in the World Mental Health Qatar (WMHQ) study were compared to diagnoses based on blinded clinician-administered reappraisal interviews.

Methods: Telephone follow-up interviews used the non-patient edition of the Structured Clinician Interview for DSM-5 (SCID) oversampling respondents who screened positive for five diagnoses in the CIDI: major depressive episode, mania/hypomania, panic disorder, generalized anxiety disorder, and obsessive-compulsive disorder. Concordance was also examined for a diagnoses of post-traumatic stress disorder based on a short-form versus full version of the PTSD Checklist for DSM-5 (PCL-5).

Exploring the knowledge and skills for effective family caregiving in elderly home care: a qualitative study.

Background: Family caregivers play a crucial role in providing physical, emotional, and social support to the elderly, allowing them to maintain their independence and stay in their preferred living environment. However, family caregivers face numerous challenges and require specific knowledge and skills to provide effective care. Therefore, understanding the knowledge and skills required for effective family caregiving in elderly home care is vital to support both the caregivers and the elderly recipients.

Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol.

is one of the oldest plants utilized by humans for both economic and medical purposes. Although the use of cannabis started millennia ago in the Eastern hemisphere, its use has moved and flourished in the Western nations in more recent centuries. is the source of psychoactive cannabinoids that are consumed as recreational drugs worldwide.

Understanding the Support Needs and Challenges Faced by Family Caregivers in the Care of Their Older Adults at Home. A Qualitative Study.

Background: As the global population ages, the demand for family caregivers is expected to increase, underscoring the necessity to comprehend their support needs and challenges they face. However, caregiving often comes with various challenges and support needs that require attention. This study was aimed to gain an in-depth understanding of the support needs and challenges faced by family caregivers who provide care to their elderly loved ones at home.

Prospective comparison of tadalafil 5 mg, dapoxetine 30 mg, and the combination of both in the treatment of premature ejaculation.

Objective: To compare the efficacy of tadalafil alone, dapoxetine alone, and tadalafil with dapoxetine as a combination therapy for the treatment of premature ejaculation.

Patients And Methods: Eligible patients attended our andrology clinic with premature ejaculation were randomly allocated into three groups: group A (92 participants) received on-demand tadalafil, 5 mg; group B (91 participants) were given on-demand dapoxetine, 30 mg; and group C (89 participants) received on-demand combination of tadalafil, 5 mg, and dapoxetine, 30 mg. We assessed the changes in the intravaginal ejaculatory latency time (IELT) and the satisfaction scores 1, 2, and 3 months after treatment.

Modified gastro-soleus turn-down flap for chronic or neglected achilles tendon ruptures.

Background: Achilles' tendon chronic rupture is a common entity that is usually misdiagnosed or mistreated. Hence, she was presented to us later or with complications affecting her gait. Surgical resection is needed to either bridge the gap or reinforce the strength of the tendon repair.

New flavonoids with multiple bronchodilator activity pathways from L. (Pers.) growing in Saudi Arabia.

Total extract of () expressed potent bronchodilator effect in isolated Guinea pigs' tracheal muscles. Fractionation of total extract ( using liquid-liquid technique followed by bronchodilator testing indicated that the activity was trapped to the chloroform (CHCl) soluble fraction. Phytochemical study of the CHCl fraction guided by bronchodilator activity led to the isolation of 7 active flavones of which compounds (Tephroapollin G), (Acetyltephroapollin C), (4''-Dehydroxytephroapollin E), and (Tephroapollin F) were new.

ethyl acetate extract improves doxorubicin antitumor outcomes against chemically induced liver cancer in rat model: a study supported by UHPLC-Q-TOF-MS/MS identification of the bioactive phytomolecules.

Hepatocellular carcinoma (HCC) is a prevalent cancer worldwide. Late-stage detection, ineffective treatments, and tumor recurrence contribute to the low survival rate of the HCC. Conventional chemotherapeutic drugs, like doxorubicin (DOX), are associated with severe side effects, limited effectiveness, and tumor resistance.

Genetic Components Derived Parameters and Heterosis in Okra under Saudi Arabia Conditions.

Four parental genotypes of okra were crossed in complete diallel design to study the direction and extent of relative heterosis and heterobeltiosis for yield and its associated traits for utilization of existing genetic diversity to develop heterotic hybrids in okra. The additive genetic component () was significant in all studied traits except average pod weight. Nonadditive ( and ) components were found to be significant in all studied traits.