Antibiotic resistance and drug modification: Synthesis, characterization and bioactivity of newly modified potent ciprofloxacin derivatives.

Development of new derivatives of commercial antibiotics using different organic reagents and testing these derivatives against different microorganisms are the main goals of this article. Thus, the antibiotic ciprofloxacin, CF, was acylated via reaction with ethyl cyanoacetate and ethyl acetoacetate in basic medium to give the cyanoacetylpiprazinyl dihydroquinoline derivative 3, and oxobutanoylpiprazinyl dihydroquinoline derivative 5, respectively. On the other hand, N-alkylated derivatives 8-10, were prepared through the reaction of CF with chloroacetonitrile, chloroacetyl acetone and chloroacetone in the presence of carbonate salt.

Synthesis and spectroscopic characterization of copper(II) complexes with the polydentate chelating ligand 4,4'-[1,4-phenylenedi(nitrilo)dipente-2-one.

A new series of complexes of 4,4'-[1,4-phenylenenedi(nitilo)]dipenten-2-one, (H(2)L) with CuX(2) x nH(2)O, X = Cl, Br, ClO(4), NO(3) and OAc; n = 1-6 as well as their ethylenediamine adducts have been synthesized and characterized by different physical techniques. The formulation of the complexes is assumed based on their elemental analysis and the molar conductivity. The products are found to be pH-dependent.