Possible protective effect of curcumin on the thyroid gland changes induced by sodium fluoride in albino rats: light and electron microscopic study.

Objectives: Thyroid gland regulates the body's metabolic rate and plays an exquisitely important role in the human health. Fluoride exposure can affect thyroid function. Curcumin is a potent antioxidant that works through several mechanisms.

Anesthetic Considerations for Patients With Congenital Central Hypoventilation Syndrome: A Systematic Review of the Literature.

Congenital central hypoventilation syndrome (CCHS) is a form of sleep-disordered breathing characterized by a diminished drive to breathe during sleep, despite progressive hypercapnia and hypoxia. The condition results from mutations in the paired-like homeobox 2B (PHOX2B) gene. The aim of this review was to conduct a systematic search of the current data on CCHS as it relates to perioperative considerations and to discuss the classification, prevalence, pathophysiology, presentation, genetics, and management of the condition.

Biological variations in adrenal gland response to immobilization and glucoprivation stressors in rats.

Objectives: The aim of the present study was to investigate the potential variation in adrenal gland response to two different types of acute stressors, immobilization and glucoprivation.

Methods: Twenty-four adult male albino rats were randomly divided into three main groups (8 rats/group): a) control, i.e.

Effect of unilateral adrenalectomy on acute immobilization stress response in rats.

Objectives: The aim of the present study was to investigate the differential effect of unilateral adrenalectomy, right vs. left, in response to acute immobilization stress (IS) in rats.

Methods: Adult male rats were subjected to unilateral right or left adrenalectomy or sham operation (control).

The effect of ghrelin antagonist (D-Lys3) GHRP-6 on ovariectomy-induced obesity in adult female albino rats.

Objective: We aimed to investigate the effect of ghrelin antagonist (D-Lys3) GHRP-6 on the treatment of ovariectomy-induced obesity as compared to hormone replacement therapy with estradiol.

Methods: Twenty eight rats were divided into four groups: control sham operated (C), ovariectomized non-treated (OVX), ovariectomized+estradiol-treated (OVX+E) groups, and ovariectomized+ghrelin antagonist-treated group (OVX+GA). Rats were allowed free water and commercial standard diet ad libitum for 5 weeks after surgery.

The effect of induction of endogenous CO by heme-oxygenase inducer, hemin versus heme-oxygenase blocker, zinc mesoporphyrin on gastric secretion and ulceration under different conditions in adult male albino rats.

Although its role and importance is less well studied, carbon monoxide (CO) has been identified as the second gasotransmitter in the GI tract. This study was performed to investigate the effect of modifying the endogenous CO production by altering heme oxygenase (HO) activity either by induction through hemin administration or inhibition by zinc mesoporphyrin administration on gastric secretion and ulceration induced by either cold restraint stress (CRS) or indomethacin (IND) treatment in adult male albino rats. Our results revealed that hemin significantly increased HO-1 levels with an increase in carboxyhemoglobin (COHb) level while zinc mesoporphyrin significantly decreased HO-1 levels with a decrease in COHb level in all groups.

Inhibition of endogenous CO by ZnPP protects against stress-induced gastric lesion in adult male albino rats.

Carbon monoxide (CO) has been found to be produced in every living cell in a biochemical reaction catalyzed by heme-oxygenase (HO) enzyme which degrades heme into biliverdin, CO, and iron. Endogenous CO is not a waste product, but acts as a chemical messenger mediating and modulating many intracellular biochemical reactions that regulate physiological functions. This study was designed to investigate the effect of inhibition of endogenous CO production by zinc protoporphyrin (ZnPP), an HO inhibitor, on the gastric secretion and ulceration induced by cold-restraint stress (CRS) in adult male albino rats.

Effect of essential fatty acid deficiency on G-proteins, cAMP-dependent protein kinase activity and mucin secretion in the rat submandibular salivary glands.

Studies were conducted to determine whether beta-adrenergic cell signalling is altered in submandibular salivary glands (SMSG) is essential fatty acid (EFA) deficiency. Three groups of rats were fed diets which were deficient in EFA (EFAD), marginally deficient in EFA (MEFAD) or contained sufficient amount of EFA (Control). Rats were killed after 20 wk on diets, SMSG were dissected out and cyclic AMP-dependent protein kinase (PKA) activity was measured.

Prostaglandin E2 production in submandibular salivary glands of rats in essential fatty acid deficiency.

Three groups of rats were fed an essential fatty acid (EFA)-deficient diet (EFAD), marginally EFA-deficient diet (MEFAD) or a control diet. Arachidonic acid levels in total phospholipids and the ex-vivo production of prostaglandin E2 (PGE2) in the presence of calcium ionophore were measured at 5 and 9 weeks in the submandibular salivary glands (SMSG). The arachidonic acid levels were significantly different among the 3 groups of rats fed the respective diets for 9 weeks.