Synthesis, computational study and biological evaluation of 9-acridinyl and 1-coumarinyl-1,2,3-triazole-4-yl derivatives as topoisomerase II inhibitors.

Topoisomerase (IIB) inhibitors have been involved in the therapies of tumour progression and have become a major focus for the development of anticancer agents. New three-component hybridised ligands, 1,4-disubstituted-1,2,3-triazoles (-), were synthesised via a 1,3-dipolar cycloaddition reaction of 9-azidoacridine/3-azidocoumarin with N/O-propargyl small molecules under click reaction conditions. Cancer cell growth inhibition of the synthesised triazoles was tested against human cell-lines in the NCI-60-cell-panel, and the most active compounds tested against topoisomerase (IIB)-enzymes.

Pathophysiology of Ichthyophthirius multifiliis infection in rainbow trout (oncorhynchus mykiss) and chub (Leuciscus cephalus).

The present study investigated the effect of experimental infection with Ichthyophthirius multifiliis on physiological, immunological and metabolic parameters in rainbow trout (Oncorhynchus mykiss) and chub (Leuciscus cephalus). Both species developed an immune response against I. multifiliis that was detected in the peripheral blood (i.

Possibilities to control Ichthyophthirius multifiliis infestation with medicated feed in rainbow trout (Oncorhynchus mykiss) and chub (Leuciscus cephalus).

In the present study, the treatment of ichthyophthiriasis with medicated feed was investigated in rainbow trout, Oncorhynchus mykiss, and chub, Leuciscus cephalus. The anti-parasitics toltrazuril and imidocarb; the antibiotics doxycycline, erythromycin and sulphadiazine and the anti-inflammatory acetylsalicylic acid were tested. In vitro experiment revealed that all tested anti-parasitics and antibiotics were effective in killing the isolated trophonts and theronts.

Comparison of aphakic refraction formulas for secondary in-the-bag intraocular lens power estimation in children.

Purpose: Intraocular lens (IOL) formulas based on aphakic refraction alone have been proposed as an alternative to biometry-based formulas. The purpose of this study was to determine the relative accuracy of these simplified formulas.

Methods: Records of patients who received secondary in-the-bag (IOL) implants and for whom aphakic refraction was obtainable were retrospectively studied.

Progression of a unilateral posterior lentiglobus associated with a persistent fetal vasculature stalk.

An 8-month-old boy was found to have unilateral persistent fetal vasculature (PFV) and a small visually insignificant lens opacity. No changes were noted in the appearance of the eye on examinations up to age 3 years. At the age of 4 years, a posterior lentiglobus requiring surgical intervention developed.