Changes in the serum, liver, and renal cortical lipids and electrolytes in rabbits with cisplatin-induced nephrotoxicity.

Background/aim: Cisplatin is an anticancer drug that can induce nephrotoxicity. Its toxicity is associated with dyslipidemia and disturbed electrolyte balance. In the present study we investigated the changes in serum lipid profile and electrolyte levels and their contents in kidney and liver tissues of rabbits treated with cisplatin.

The ameliorative effects of virgin olive oil and olive leaf extract on amikacin-induced nephrotoxicity in the rat.

Unlabelled: Amikacin is an important antibiotic, and its use is limited because of the induced nephrotoxicity. Thus, search for natural and synthetic agents that can moderate amikacin toxicity never stopped. The present study aims to investigate the possible ameliorative effects of virgin olive oil and olive leaf extract against the amikacin-induced nephrotoxicity in rat.

Serum vitamin D and parathyroid hormone profiles in patients with various stages of renal disease.

Background: The prevalence of vitamin D deficiency among Saudi population has increased recently. The social and pathological factors, including kidney disease that may have influenced the vitamin status have not been investigated in the Hail population.

Aims: The present study aims to: (1) investigate changes in the serum vitamin D, parathyroid hormone, serum calcium, and phosphate levels in Saudi patients with kidney disease; and (2) elucidate the other possible physiological factors that may have influence on the vitamin status.

Dyslipidemia and serum mineral profiles in patients with thyroid disorders.

Objectives: To investigate changes in serum lipid profile, levels of serum minerals associated with thyroid disorders, and to compare these with the serum lipid and mineral profiles in hypothyroid patients receiving thyroxine therapy.

Methods: A cross-sectional study was conducted in King Khaled Hospital, Hail, Saudi Arabia. The patient database was searched for new patients with thyroid dysfunction between January 2011 and June 2012.

The secondary dyslipidemia and deranged serum phosphate concentration in thyroid disorders.

Hyperlipidemia is a secondary disorder associated with many metabolic disorders including hypothyroidism. The occurrence of dyslipidemia in subclinical hypothyroidism is controversial. Hyperphosphatemia may accompany the dyslipidemia in some metabolic disorders.

The effect of glycemic control in type 2 diabetic patients with diabetes-related dyslipidemia.

Objective: The study was planned to investigate whether the serum lipid profile in type 2 diabetes mellitus was different between groups of patients classified as having good, satisfactory or poor glycemic controls, depending on their serum fructosamine levels.

Methods: The study was carried out in the Department of Laboratory, Dammam College for Health Sciences, Dammam, Kingdom of Saudi Arabia between February 2003 to June 2003. Clinical laboratory data from diagnosed type 2 diabetic patients were used in the study.

Effect of spironolactone on cisplatin-induced nephrotoxicity in rabbits.

The effects of a single interaperitoneal dose of cisplatin (6.5 mg kg day(-1)), oral doses of spironolactone (20.0 mg kg day(-1)) for 5 days or the combined treatment (spironolactone+cisplatin) on the kidney function and liver function parameters, as well as the serum, liver and kidney cortical lipid contents were studied.

Effect of high dietary cholesterol on gentamicin-induced nephrotoxicity in rabbits.

Administration of gentamicin to rabbits intramuscularly at a dose of 80 mg/kg per day for 5 days induced nephrotoxicity exhibited by significantly (P < 0.001) elevated serum urea and creatinine levels and a significant (P < 0.001) decrease in renal cortical alkaline phosphatase (ALP) activity, in addition to tubular necrosis revealed by the histopathological examination of the kidney cortices.

Plasma and hepatic lipid profiles in furazolidone-treated rats.

Rats were treated orally with furazolidone (FZ) at doses of 50, 100, and 200 mg/kg body weight for three consecutive days. The parameters determined in plasma included: total cholesterol, high density (HDL) cholesterol, low-density (VLDL+LDL) cholesterol, triglycerol (TAG), phospholipids (PL), and lipoprotein lipase. In the liver, cholesterol, TAG and phospholipid concentrations were measured.

Hyperlipidaemia in cisplatin-induced nephrotic rats.

The serum and hepatic lipid concentrations were investigated in rats made nephrotic with a single intraperitoneal injection of cisplatin (6 mg kg(-1) b.wt.).

Effect of selenium on vanadium toxicity in different regions of rat brain.

The protective effect of selenium on the neurotoxicity of vanadium in different brain regions of rats was investigated. The lipid peroxidation was significantly accentuated after intraperitoneal (i.p.

Effects of fish oil and sunflower oil supplementations on gentamicin-induced nephrotoxicity in rat.

1. Nephrotoxicity was induced in rats by intramuscular administration of gentamicin (80 mg k-1 d-1) for 6 days. 2.

Effect of gentamicin-induced nephrotoxicity on some carbohydrate metabolic pathways in the rat renal cortex.

Rats were injected with gentamicin at doses of 20, 40 and 80 mg/kg per day for 6 consecutive days. The treatment caused nephrotoxicity as evidenced by dose-related increases in serum creatinine concentration and renal tubular necrosis. The nephrotoxicity was accompanied by reduced renal cortical and fasting blood glucose levels, and by increases in serum lactate concentrations.

Plasma lipid profile in rats with gentamicin-induced nephrotoxicity.

1. Administration of gentamicin to rats at doses of 20, 40 or 80 mg kg-1 d-1 for 6 days induced nephrotoxicity exhibited by elevated plasma creatinine concentration and a decrease in alkaline phosphatase activity in rat kidney cortex. 2.

Effect of chloroquine on some carbohydrate metabolic pathways: contents of GHS, ascorbate and lipid peroxidation in the rat.

Adult male rats were treated intraperitoneally with chloroquine (5 mg/kg/day) for 9 days. A reduction in the fasting plasma glucose level by 17.6% and ascorbic acid by 45% were discernable.

Gentamicin nephrotoxicity in rat: some biochemical correlates.

The present work examines the effect of treatment of rats with graded doses of the aminoglycoside antibiotic gentamicin on the concentration of reduced glutathione (GSH) and diamine oxidase (DAO) activity in the kidney, and DAO activity, creatinine and magnesium (Mg) in the plasma. The animals were given the antibiotic intramuscularly in doses of 20, 40, and 80 mg/kg/day for 6 days, and were killed 24 hr after the last injection. In another experiment rats were injected intramuscularly with gentamicin at a dose of 80 mg/kg/day for 6 days and were killed 1, 7 or 14 days after the last injection, and the above parameters were measured.

Lipid peroxidation, glutathione and ascorbic acid concentrations in tissues of mice treated with oltipraz: influence of cysteine and olive oil pretreatments.

1. The effects of treatment with the antischistosomal drug oltipraz on reduced glutathione (GSH), lipid peroxide (LP) and ascorbic acid (AA) concentrations in the liver, kidney and brain were studied in mice 24 h after drug administration. 2.

Glutathione and ascorbic acid concentrations in the duodenum of rats with cysteamine-induced ulcers: influence of cysteine and ascorbic acid pretreatments.

Duodenal ulceration in rats was induced by a single subcutaneous injection of cysteamine at doses of 7, 28, 42 and 65 mg/100 g body weight 24 h before killing. Duodenal ulceration induced by cysteamine was dose-dependent. However, at 65 mg/100 g body weight, 5 of 6 animals died within 24 h.