Does combined prednisolone and low molecular weight heparin have a role in unexplained implantation failure?

Purpose: To study the effect of combined oral prednisolone and LMW heparin in ICSI in women with previously unexplained, failed implantation.

Methods: A prospective quasi-randomized, controlled trial was conducted at a university teaching hospital and a private practice setting. A total of 334 cycles (women with previously unexplained, failed one or two ICSI attempts) were assigned randomly to receive standard treatment or combined prednisolone (20 mg/day), starting on the first day of ovarian stimulation and LMW heparin 1 mg/kg/day starting 1 day after oocyte retrieval in addition to standard treatment.