-trivial deformation of -modules structure on the spaces of symbols of differential operators acting on the space of weighted densities .

Let be the orthosymplectic Lie superalgebra and a Lie subalgebra of . In our paper, we describe the cup-product , where is the first differential -relative cohomology of with coefficients in and is the space of linear differential operators acting on weighted densities. This result allows us to classify the -trivial deformations of the -module structure on the spaces of symbols .

Atypical Cogan's syndrome: A case report.

Cogan's syndrome is a rare autoimmune inflammatory disease, characterized by interstitial keratitis and audio-vestibular signs. The syndrome was first described in 1945 by David G. Cogan.

Prevalence and predictors of metamorphopsia after successful vitrectomy surgery for macula-off rhegmatogenous retinal detachment.

Aim: To estimate metamorphopsia prevalence, predictors and etiologies in patients operated for rhegmatogenous retinal detachment (RRD) with detached macula with successful results.

Methods: Retrospective study including 50 eyes of 50 patients who underwent pars plana vitrectomy for RRD with detached macula with standard silicone oil (SO) tamponade. Patients who had successful surgery with durable anatomic reapplication of the retina after SO removal were included.

The relationship between solvatochromic properties and in silico ADME parameters of new chloroethylnitrosourea derivatives with potential anticancer activity and their β-Cyclodextrin complexes.

In view of the anticancer effect of nitrosoureas a set of four new N-(2-chloroethyl)-N-nitrosourea (CENU) derivatives was synthesized. An in silico absorption, distribution, metabolism, excretion and toxicity (ADME/Tox) prediction study revealed that the CENU derivatives satisfied all the required criteria for oral administration and introduced them as remarkable anticancer candidates in the central nervous system (CNS). A comparative solvatochromic study including the Kamlet-Taft, Catalán and Laurence models indicated that the solvatochromic behavior of the CENUs depended on both, unspecific and specific solvent-solute interactions.

Spectrofluorimetric determination of the antineoplastic agent lomustine based on the sensitizing effect of β-cyclodextrin.

The effects of solvent dipolarity/polarizability and solvent-solute hydrogen bonding on the photophysical properties of the antineoplastic drug lomustine were analysed by means of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The LSER method enabled the overall solvent effects to be quantitatively estimated and separated into specific and non-specific contributions. The molecular encapsulation of lomustine by β-cyclodextrin (β-CD) has been studied using fluorescence spectroscopy.

A spectrophotometric and thermodynamic study of the charge-transfer complexes of N-aryl-N'-isopropyloxycarbonylsulfamides with DDQ and TCNE.

Molecular charge-transfer complexes of three N-aryl-N'-isopropyloxycarbonylsulfamides derivatives with π-acceptors tetracyanoethylene (TCNE), and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), were studied by using zero and second order derivative UV spectrophotometry in different solvents at four different temperatures within the range of 20-35 °C. The stoichiometries of the complexes were found to be 1:1 ratio between donors and acceptors using Job's method. The data were analyzed in terms of their stability constant (K), molar extinction coefficient (εCT), thermodynamic standard reaction quantities (ΔG°, ΔH°, ΔS°), oscillator strength (f), transition dipole moment (μEN) and ionization potential (ID).

Solvent effects of N-nitroso, N-(2-chloroethyl), N',N'-dibenzylsulfamid and its copper(II) and cobalt(II) complexes: fluorescence studies.

The structure of N-nitroso, N-(2-chloroethyl), N',N'-dibenzylsulfamid (CENS) was established by X-ray crystallography. The atomic coordinates, factors of isotropic thermal agitation, bond lengths and valence angles were determined. The solvent effects on the electronic absorption and fluorescence spectra of CENS were investigated at room temperature.

tert-Butyl N-[N,N-bis-(2-chloro-ethyl)sulfamo-yl]-N-(2-chloro-ethyl)carbamate.

The title compound, C(11)H(21)Cl(3)N(2)O(4)S, was produced as part of a development programme of a new synthetic route to chloro-ethyl-nitro-sosulfamides (CENS) with three chloro-ethyl moieties. These compounds possess structural features that confer potential biological activity and act as alkyl-ating agents. The packing is governed by four weak C-H⋯O inter-actions, forming an infinite three-dimensional network.

Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II.

An approach for the synthesis of carbonic anhydrase (CA, EC 4.2.1.

Synthesis of substituted N-aryl-N'-Sulfamoyloxazolidin-2-ones with potential antibacterial activity.

Three series of derived compounds of N, Aryl-N',Sulfamoyloxazolidin-2-ones were synthesized starting from chloro-sulfonylisocyanate (CSI) by carbomoylation, sulfamoylation and intramolecular cyclization reactions followed by methylation and heterocyclic reopening reactions. This later is based on a new hydrolysis method which uses a solid support, in order to obtain the correspondent amino-alcohols, which allowed isolating a new amino-alcohol ester. Measurements of the hydro-solubility by determination partition coefficient (log p) in water/octanol system were carried out by spectrophotometry.

Study on the decomposition of 2-chloroethylnitro- sosulfamides (CENS) in serum using HPLC on-line solid phase extraction.

In this paper we have investigated the kinetic decomposition of 2-chloroethylnitrososulfamides (CENS) in fetal calf serum. The study was monitored by on-line solid phase extraction linked to RP-LC-MS. We demonstrated that CENS are less stable in fetal calf serum than in aqueous buffer at pH 7.

Kinetic investigation on aqueous decomposition of 2-chloroethylnitrososulfamide.

The kinetics decomposition of 2-chloroethylnitrososulfamides (CENS) was studied in aqueous buffered solutions with pH ranging from 0 to 14. The study was monitored by RP-LC-MS and conventional UV spectrophotometry. The reaction proceeded via a pseudo-first-order kinetic with significant correlation coefficient.

Inclusion complexes of N-sulfamoyloxazolidinones with beta-cyclodextrin.

A study of inclusion complexes of six N-sulfamoyloxazolidinone derivatives with beta-cyclodextrin is described. The inclusion complexes were prepared in solution and in solid state with stoichiometry host-guest 1:1, and characterized. In solution, the complexation was carried out by spectrophotometric measurements at 25 degrees C.

Inclusion complexes of 2-chloroethylnitrososulfamides (CENS) with beta-cyclodextrin.

Host-guest association between four CENS (derivated from piperidine, dibenzylamine, dicyclohexylamine and methyl prolinate) and beta-cyclodextrin was carried out in solution and solid state. Characterisation, stoichiometry, solubility, dissociation constants and stability of such complexes were studied, showing that the inclusion with beta-CD appears as a promising mode of formulation of 2-chloroethylnitrososulfamides.

A new family of potential oncostatics: 2-chloroethylnitrososulfamides (CENS)--I. Synthesis, structure, and pharmacological evaluation (preliminary results).

A new series of alkylating agents, 2-chloroethylnitrososulfamides (CENS), were developed on the model of 2-chloroethylnitrosoureas. Starting from chlorosulfonyl isocyanate, a four-step synthesis (carbamoylation-sulfamoylation, Mitsunobu alkylation, deprotection, and nitrosation) gives the title compounds in a 47-58% overall yield. The selection of the nitrosation site can be directed through an alternative route.